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Co-crystal structure of NAMPT dimer with KPT-9274
Descriptor:	(~{E})-3-(6-azanylpyridin-3-yl)-~{N}-[[5-[4-[4,4-bis(fluoranyl)piperidin-1-yl]carbonylphenyl]-7-(4-fluorophenyl)-1-benzofuran-2-yl]methyl]prop-2-enamide, GLYCEROL, Nicotinamide phosphoribosyltransferase, ...
Authors:	Neggers, J.E, Kwanten, B, Dierckx, T, Noguchi, H, Voet, A, Vercruysse, T, Baloglu, E, Senapedis, W, Jacquemyn, M, Daelemans, D.
Deposit date:	2017-04-26
Release date:	2018-02-14
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (2.046 Å)
Cite:	Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes. Nat Commun, 9, 2018

Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
Authors:	Sun, Q, Chook, Y.M.
Deposit date:	2012-08-16
Release date:	2012-10-17
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia. Blood, 120, 2012

Luminal domain of TMEM106B
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:	Pye, V.E, Roustan, C, Cherepanov, P.
Deposit date:	2022-09-29
Release date:	2023-07-19
Last modified:	2024-05-01
Method:	X-RAY DIFFRACTION (2.59 Å)
Cite:	TMEM106B is a receptor mediating ACE2-independent SARS-CoV-2 cell entry. Cell, 186, 2023