4O04
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![BU of 4o04 by Molmil](/molmil-images/mine/4o04) | Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease | Descriptor: | 4-(2,7,7-trimethyl-5-oxo-1,2,3,4,5,6,7,8-octahydro-9H-beta-carbolin-9-yl)benzamide, Heat shock protein HSP 90-alpha | Authors: | Zuccola, H.J, Ernst, J. | Deposit date: | 2013-12-13 | Release date: | 2014-12-24 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Identification of Novel HSP90 alpha / beta Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington's Disease. J.Med.Chem., 57, 2014
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4O0B
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![BU of 4o0b by Molmil](/molmil-images/mine/4o0b) | Identification of novel HSP90/isoform selective inhibitors using structure-based drug design. Demonstration of potential utility in treating CNS disorders such as Huntington's disease | Descriptor: | 8-cyclopentyl-6-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)-3,4-dihydroisoquinolin-1(2H)-one, Heat shock protein HSP 90-alpha | Authors: | Zuccola, H.J, Ernst, J.T. | Deposit date: | 2013-12-13 | Release date: | 2014-04-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Identification of Novel HSP90 alpha / beta Isoform Selective Inhibitors Using Structure-Based Drug Design. Demonstration of Potential Utility in Treating CNS Disorders such as Huntington's Disease. J.Med.Chem., 57, 2014
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6WXJ
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![BU of 6wxj by Molmil](/molmil-images/mine/6wxj) | CSF1R signaling is a regulator of pathogenesis in progressive MS | Descriptor: | 4-(3-{[(2S)-2-(6-methoxypyridin-3-yl)-2,3-dihydro-1,4-benzodioxin-6-yl]methyl}-3H-imidazo[4,5-b]pyridin-6-yl)-2-methylbut-3-yn-2-amine, Macrophage colony-stimulating factor 1 receptor | Authors: | Liu, J. | Deposit date: | 2020-05-10 | Release date: | 2021-02-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | CSF1R signaling is a regulator of pathogenesis in progressive MS. Cell Death Dis, 11, 2020
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2QDQ
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![BU of 2qdq by Molmil](/molmil-images/mine/2qdq) | Crystal structure of the talin dimerisation domain | Descriptor: | Talin-1 | Authors: | Gingras, A.R, Putz, N.S.M, Bate, N, Barsukov, I.L, Critchley, D.R.C. | Deposit date: | 2007-06-21 | Release date: | 2008-01-29 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The structure of the C-terminal actin-binding domain of talin. Embo J., 27, 2008
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4XIQ
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![BU of 4xiq by Molmil](/molmil-images/mine/4xiq) | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors | Descriptor: | 8,11,11-trimethyl-9-oxo-6,7,9,10,11,12-hexahydroindolo[2,1-d][1,5]benzoxazepine-3-carboxamide, GLYCEROL, Heat shock protein HSP 90-alpha | Authors: | Neubert, T, Zuccola, H.J. | Deposit date: | 2015-01-07 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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4XIT
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![BU of 4xit by Molmil](/molmil-images/mine/4xit) | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors | Descriptor: | 2-chloro-5-(furan-2-ylmethyl)-8,11,11-trimethyl-9-oxo-6,7,9,10,11,12-hexahydro-5H-indolo[1,2-a][1,5]benzodiazepine-3-carboxamide, GLYCEROL, Heat shock protein HSP 90-alpha | Authors: | Zuccola, H.J, Neubert, T. | Deposit date: | 2015-01-07 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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4XIR
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![BU of 4xir by Molmil](/molmil-images/mine/4xir) | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors | Descriptor: | (6S)-2-chloro-8,11,11-trimethyl-9-oxo-6-propyl-6,7,9,10,11,12-hexahydroindolo[2,1-d][1,5]benzoxazepine-3-carboxamide, GLYCEROL, Heat shock protein HSP 90-alpha | Authors: | Neubert, T, Zuccola, H.J. | Deposit date: | 2015-01-07 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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4XIP
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![BU of 4xip by Molmil](/molmil-images/mine/4xip) | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors | Descriptor: | 4-(3,6,6-trimethyl-4-oxo-4,5,6,7-tetrahydro-1H-indol-1-yl)benzamide, Heat shock protein HSP 90-alpha | Authors: | Zuccola, H.J, Neubert, T. | Deposit date: | 2015-01-07 | Release date: | 2015-03-04 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Discovery of novel oxazepine and diazepine carboxamides as two new classes of heat shock protein 90 inhibitors. Bioorg.Med.Chem.Lett., 25, 2015
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2JSW
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![BU of 2jsw by Molmil](/molmil-images/mine/2jsw) | Solution Structure of the R13 Domain of Talin | Descriptor: | Talin-1 | Authors: | Goult, B.T, Gingras, A.R, Bate, N, Critchley, D.R.C, Barsukov, I.L. | Deposit date: | 2007-07-17 | Release date: | 2008-01-29 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | The structure of the C-terminal actin-binding domain of talin. Embo J., 27, 2007
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2BPA
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![BU of 2bpa by Molmil](/molmil-images/mine/2bpa) | ATOMIC STRUCTURE OF SINGLE-STRANDED DNA BACTERIOPHAGE PHIX174 AND ITS FUNCTIONAL IMPLICATIONS | Descriptor: | DNA (5'-D(*AP*AP*AP*AP*C)-3'), PROTEIN (SUBUNIT OF BACTERIOPHAGE PHIX174) | Authors: | McKenna, R, Xia, D, Willingmann, P, Ilag, L.L, Krishnaswamy, S, Rossmann, M.G, Olson, N.H, Baker, T.S, Incardona, N.L. | Deposit date: | 1991-12-03 | Release date: | 1991-12-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Atomic structure of single-stranded DNA bacteriophage phi X174 and its functional implications. Nature, 355, 1992
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1GFF
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![BU of 1gff by Molmil](/molmil-images/mine/1gff) | |
1AL0
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![BU of 1al0 by Molmil](/molmil-images/mine/1al0) | PROCAPSID OF BACTERIOPHAGE PHIX174 | Descriptor: | CAPSID PROTEIN GPF, SCAFFOLDING PROTEIN GPB, SCAFFOLDING PROTEIN GPD, ... | Authors: | Rossmann, M.G, Dokland, T. | Deposit date: | 1997-06-06 | Release date: | 1998-01-28 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Structure of a viral procapsid with molecular scaffolding. Nature, 389, 1997
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