2I03
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![BU of 2i03 by Molmil](/molmil-images/mine/2i03) | Crystal structure of human dipeptidyl peptidase 4 (DPP IV) with potent alkynyl cyanopyrrolidine (ABT-279) | Descriptor: | 2-[4-({2-[(2S,5R)-2-(AMINOMETHYL)-5-ETHYNYLPYRROLIDIN-1-YL]-2-OXOETHYL}AMINO)-4-METHYLPIPERIDIN-1-YL]ISONICOTINIC ACID, Dipeptidyl peptidase 4 | Authors: | Longenecker, K.L, Madar, D.J. | Deposit date: | 2006-08-09 | Release date: | 2006-12-12 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes. J.Med.Chem., 49, 2006
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1PRO
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![BU of 1pro by Molmil](/molmil-images/mine/1pro) | HIV-1 PROTEASE DIMER COMPLEXED WITH A-98881 | Descriptor: | (5R,6R)-2,4-BIS-(4-HYDROXY-3-METHOXYBENZYL)-1,5-DIBENZYL-3-OXO-6-HYDROXY-1,2,4-TRIAZACYCLOHEPTANE, HIV-1 PROTEASE | Authors: | Park, C.H, Kong, X.P, Dealwis, C.G. | Deposit date: | 1995-07-18 | Release date: | 1996-08-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A novel, picomolar inhibitor of human immunodeficiency virus type 1 protease. J.Med.Chem., 39, 1996
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3JXW
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![BU of 3jxw by Molmil](/molmil-images/mine/3jxw) | |
3JY0
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![BU of 3jy0 by Molmil](/molmil-images/mine/3jy0) | |
3JYA
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![BU of 3jya by Molmil](/molmil-images/mine/3jya) | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors | Descriptor: | 6,9-dichloro[1]benzothieno[3,2-d]pyrimidin-4(3H)-one, Proto-oncogene serine/threonine-protein kinase Pim-1 | Authors: | Stoll, V.S. | Deposit date: | 2009-09-21 | Release date: | 2009-11-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of 3H-benzo[4,5]thieno[3,2-d]pyrimidin-4-ones as Potent, Highly Selective and Orally Bioavailable Pim Kinases Inhibitors TO BE PUBLISHED
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3LZB
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![BU of 3lzb by Molmil](/molmil-images/mine/3lzb) | EGFR kinase domain complexed with an imidazo[2,1-b]thiazole inhibitor | Descriptor: | Epidermal growth factor receptor, N-[3-(5-{2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[2,1-b][1,3]thiazol-6-yl)phenyl]-2-phenylacetamide | Authors: | Swinger, K.K. | Deposit date: | 2010-03-01 | Release date: | 2011-03-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases. Bioorg.Med.Chem.Lett., 20, 2010
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1N49
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![BU of 1n49 by Molmil](/molmil-images/mine/1n49) | Viability of a Drug-Resistant HIV-1 Protease Variant: Structural Insights for Better Anti-Viral Therapy | Descriptor: | Protease, RITONAVIR | Authors: | Prabu-Jeyabalan, M, Nalivaika, E.A, King, N.M, Schiffer, C.A. | Deposit date: | 2002-10-30 | Release date: | 2003-01-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Viability of a Drug-Resistant Human Immunodeficiency Virus Type 1 Protease Variant:
Structural Insights for Better Antiviral Therapy J.VIROL., 77, 2003
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1HQB
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![BU of 1hqb by Molmil](/molmil-images/mine/1hqb) | TERTIARY STRUCTURE OF APO-D-ALANYL CARRIER PROTEIN | Descriptor: | APO-D-ALANYL CARRIER PROTEIN | Authors: | Volkman, B.F, Zhang, Q, Debabov, D.V, Rivera, E, Kresheck, G, Neuhaus, F.C. | Deposit date: | 2000-12-14 | Release date: | 2001-08-01 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Biosynthesis of D-alanyl-lipoteichoic acid: the tertiary structure of apo-D-alanyl carrier protein. Biochemistry, 40, 2001
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