8IYH
 
 | | Structure of MK6892-GPR109A-G-protein complex | | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-04-04 | | Release date: | 2024-03-06 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
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8IYW
 | | Structure of GSK256073-GPR109A-G-protein complex | | Descriptor: | 8-chloranyl-3-pentyl-7H-purine-2,6-dione, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-04-06 | | Release date: | 2024-03-06 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
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6F3V
 | | Backbone structure of bradykinin (BK) peptide bound to human Bradykinin 2 Receptor (B2R) determined by MAS SSNMR | | Descriptor: | Bradykinin (BK) | | Authors: | Mao, J, Lopez, J.J, Shukla, A.K, Kuenze, G, Meiler, J, Schwalbe, H, Michel, H, Glaubitz, C. | | Deposit date: | 2017-11-29 | | Release date: | 2018-01-10 | | Last modified: | 2024-06-19 | | Method: | SOLID-STATE NMR | | Cite: | The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
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6F3W
 | | Backbone structure of free bradykinin (BK) in DDM/CHS detergent micelle determined by MAS SSNMR | | Descriptor: | Kininogen-1 | | Authors: | Mao, J, Lopez, J.J, Shukla, A.K, Kuenze, G, Meiler, J, Schwalbe, H, Michel, H, Glaubitz, C. | | Deposit date: | 2017-11-29 | | Release date: | 2018-01-10 | | Last modified: | 2024-06-19 | | Method: | SOLID-STATE NMR | | Cite: | The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
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8JZZ
 | | Structure of human C5a-desArg bound human C5aR1 in complex with Go | | Descriptor: | Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | Authors: | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | | Deposit date: | 2023-07-06 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.31 Å) | | Cite: | Molecular basis of anaphylatoxin binding, activation, and signaling bias at complement receptors.
Cell, 186, 2023
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8JER
 | | Structure of Acipimox-GPR109A-G protein complex | | Descriptor: | 5-methyl-4-oxidanyl-pyrazin-4-ium-2-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-05-16 | | Release date: | 2024-03-06 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
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8JHN
 | | Structure of MMF-GPR109A-G protein complex | | Descriptor: | G protein subunit alpha o1,Guanine nucleotide-binding protein G(o) subunit alpha, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Yadav, M.K, Sarma, P, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-05-24 | | Release date: | 2024-03-06 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.75 Å) | | Cite: | Structure-guided engineering of biased-agonism in the human niacin receptor via single amino acid substitution.
Nat Commun, 15, 2024
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8JA3
 | | Structure of beta-arrestin1 in complex with C3aRpp | | Descriptor: | Beta-arrestin-1, C3a anaphylatoxin chemotactic receptor, Fab30 heavy chain, ... | | Authors: | Maharana, J, Sarma, P, Yadav, M.K, Chami, M, Banerjee, R, Shukla, A.K. | | Deposit date: | 2023-05-05 | | Release date: | 2023-12-27 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.94 Å) | | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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8JAF
 | | Structure of Muscarinic receptor (M2R) in complex with beta-arrestin1 (Local Refine, non-cross linked) | | Descriptor: | Beta-arrestin-1, Fab30 heavy chain, Fab30 light chain, ... | | Authors: | Maharana, J, Sano, F.K, Shihoya, W, Banerjee, R, Nureki, O, Shukla, A.K. | | Deposit date: | 2023-05-05 | | Release date: | 2023-12-27 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Molecular insights into atypical modes of beta-arrestin interaction with seven transmembrane receptors.
Science, 383, 2024
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8JZP
 | | Structure of mouse C5a-human C5aR1-Go complex | | Descriptor: | Antibody fragment ScFv16, C5a anaphylatoxin, C5a anaphylatoxin chemotactic receptor 1, ... | | Authors: | Yadav, M.K, Yadav, R, Maharana, J, Sarma, P, Banerjee, R, Shukla, A.K, Gati, C. | | Deposit date: | 2023-07-06 | | Release date: | 2025-01-15 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structure of mouse C5a-human C5aR1-Go complex
To Be Published
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8JPS
 | | Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CCL7 (Composite map) | | Descriptor: | Atypical chemokine receptor 1, C-C motif chemokine 7 | | Authors: | Banerjee, R, Khanppnavar, B, Maharana, J, Saha, S, Korkhov, V.M, Shukla, A.K. | | Deposit date: | 2023-06-12 | | Release date: | 2024-07-31 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.
Cell, 187, 2024
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8XWF
 | | Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 3 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.65 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWN
 | | Structure of CXCR2 bound to CXCL8 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, MDNCF-a | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.29 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XVU
 | | Structure of CXCR2 bound to CXCL2 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 2 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-15 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XX7
 | | Structure of CXCR2 bound to CXCL5 (CXCR2-CXCL5-Go Full map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 5, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWA
 | | Structure of CXCR2 bound to CXCL1 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, Growth-regulated alpha protein | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.48 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWS
 | | Structure of CXCR2 bound to CXCL5 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 5 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XXH
 | | Structure of CXCR2 bound to CXCL2 (CXCR2-CXCL2-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-18 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWM
 | | Structure of CXCR2 bound to CXCL6 (Ligand-receptor focused map) | | Descriptor: | C-X-C chemokine receptor type 2, C-X-C motif chemokine 6 | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XXR
 | | Structure of CXCR2 bound to CXCL6 (CXCR2-CXCL6-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-18 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XX3
 | | Structure of CXCR2 bound to CXCL3 (CXCR2-CXCL3-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 3, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.38 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XX6
 | | Structure of CXCR2 bound to CXCL8 (CXCR2-CXCL8-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-17 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (2.99 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XXX
 | | Structure of CXCR2 bound to CXCL6 (Composite map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, C-X-C motif chemokine 6, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-19 | | Release date: | 2025-01-15 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.17 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8XWV
 | | Structure of CXCR2 bound to CXCL1 (CXCR2-CXCL1-Go Full map) | | Descriptor: | Antibody fragment ScFv16, C-X-C chemokine receptor type 2, Growth-regulated alpha protein, ... | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-16 | | Release date: | 2025-01-22 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.07 Å) | | Cite: | Molecular basis of promiscuous chemokine binding and structural mimicry at the C-X-C chemokine receptor, CXCR2.
Mol.Cell, 85, 2025
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8Y0H
 | | Structure of CXCR3 in complex with VUF11418 (Receptor-ligand focused map) | | Descriptor: | C-X-C chemokine receptor type 3, [(1~{R},5~{S})-6,6-dimethyl-2-bicyclo[3.1.1]hept-2-enyl]methyl-[[4-(2-iodanylphenyl)phenyl]methyl]-dimethyl-azanium | | Authors: | Sano, F.K, Saha, S, Sharma, S, Ganguly, M, Shihoya, W, Nureki, O, Shukla, A.K, Banerjee, R. | | Deposit date: | 2024-01-22 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-09 | | Method: | ELECTRON MICROSCOPY (3.53 Å) | | Cite: | Structural visualization of small molecule recognition by CXCR3 uncovers dual-agonism in the CXCR3-CXCR7 system.
Nat Commun, 16, 2025
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