8SCN
| Bst DNA polymerase I Large Fragment mutant F710Y/D598A with 3'-amino primer, dGTP, and calcium time-resolved 24h (Product State) | Descriptor: | CALCIUM ION, DIPHOSPHATE, DNA polymerase I, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8TDY
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8TE0
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8TDZ
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8SCP
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 1h | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCQ
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 2h | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCR
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 4h | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCS
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 8h | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCT
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 24h | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8SCU
| Bst DNA polymerase I Large Fragment wildtype D598A with 3'-amino primer, dGTP, and calcium time-resolved 48h (Product State) | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DIPHOSPHATE, ... | Authors: | Fang, Z, Lelyveld, V.S, Szostak, J.W. | Deposit date: | 2023-04-05 | Release date: | 2023-10-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Trivalent rare earth metal cofactors confer rapid NP-DNA polymerase activity. Science, 382, 2023
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8TE2
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7KUO
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7KUN
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7KUK
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7KUM
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7KUL
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7KUP
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7LNF
| 3'-deoxy modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | Descriptor: | 3'-deoxy-guanosine 5'-monophosphate, 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, COBALT (II) ION, ... | Authors: | Fang, Z, Giurgiu, C, Szostak, J.W. | Deposit date: | 2021-02-07 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.652 Å) | Cite: | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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7LNG
| TNA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | Descriptor: | 2-azanyl-9-[(2~{R},3~{R},4~{S})-3-oxidanyl-4-[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxy-oxolan-2-yl]-1~{H}-purin-6-one, 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, DIGUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Fang, Z, Giurgiu, C, Szostak, J.W. | Deposit date: | 2021-02-07 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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7LNE
| ANA modification at 3' end of RNA primer complex with guanosine dinucleotide ligand G(5')ppp(5')G | Descriptor: | 4-AMINO-1-[(1S,3R,4R,7S)-7-HYDROXY-1-(HYDROXYMETHYL)-2,5-DIOXABICYCLO[2.2.1]HEPT-3-YL]-5-METHYLPYRIMIDIN-2(1H)-ONE, DIGUANOSINE-5'-TRIPHOSPHATE, GUANINE ARABINOSE-5'-PHOSPHATE, ... | Authors: | Fang, Z, Giurgiu, C, Szostak, J.W. | Deposit date: | 2021-02-07 | Release date: | 2021-09-08 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Structure-Activity Relationships in Nonenzymatic Template-Directed RNA Synthesis. Angew.Chem.Int.Ed.Engl., 60, 2021
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8FEO
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8FEQ
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8FEP
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8FER
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7U8B
| Product of 14mer primer with activated asymmetric GA dimer diastereomer 1 | Descriptor: | 5'-O-[(S)-(2-amino-1H-imidazol-1-yl)(hydroxy)phosphoryl]adenosine, RNA (5'-R(*(TLN)P*(LCC)P*(LCC)P*(LCG)P*AP*CP*UP*UP*AP*AP*GP*UP*CP*GP*(G46))-3'), SULFATE ION | Authors: | Fang, Z, Szostak, J.W. | Deposit date: | 2022-03-08 | Release date: | 2023-03-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Understanding the metal ion function in the RNA non-enzymatic extesion with phosphorothioates To Be Published
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