Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2VCM
DownloadVisualize
BU of 2vcm by Molmil
Isopenicillin N synthase with substrate analogue AsMCOV
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R,2S)-1-({[(1R)-1-carboxy-2-methylpropyl]oxy}carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine, ...
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-09-25
Release date:2008-11-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue.
Chembiochem, 10, 2009
2VAU
DownloadVisualize
BU of 2vau by Molmil
Isopenicillin N synthase with substrate analogue ACOMP (unexposed)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N6^-[(1R)-2-[(1S)-1-CARBOXY-2-(METHYLSULFANYL)ETHOXY]-2-OXO-1-(SULFANYLMETHYL)ETHYL]-6-OXO-L-LYSINE
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-09-04
Release date:2008-07-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?
J.Am.Chem.Soc., 130, 2008
2VE1
DownloadVisualize
BU of 2ve1 by Molmil
Isopenicillin N synthase with substrate analogue AsMCOV (oxygen exposed 1min 20bar)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R,2S)-1-({[(1R)-1-carboxy-2-methylpropyl]oxy}carbonyl)-2-sulfanylpropyl]-6-oxo-L-lysine, ...
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-10-15
Release date:2008-11-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with a Sterically Demanding Depsipeptide Substrate Analogue.
Chembiochem, 10, 2009
2VBB
DownloadVisualize
BU of 2vbb by Molmil
Isopenicillin N synthase with substrate analogue ACOMP (35minutes oxygen exposure)
Descriptor: FE (II) ION, GLYCEROL, ISOPENICILLIN N SYNTHETASE, ...
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-09-07
Release date:2008-07-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Isopenicillin N Synthase Mediates Thiolate Oxidation to Sulfenate in a Depsipeptide Substrate Analogue: Implications for Oxygen Binding and a Link to Nitrile Hydratase?
J.Am.Chem.Soc., 130, 2008
2VBD
DownloadVisualize
BU of 2vbd by Molmil
Isopenicillin N synthase with substrate analogue L,L,L-ACOMP (unexposed)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R)-2-[(1R)-1-carboxy-2-(methylsulfanyl)ethoxy]-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-09-10
Release date:2008-09-23
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of an Lll-Configured Depsipeptide Substrate Analogue Bound to Isopenicillin N Synthase.
Org.Biomol.Chem., 8, 2010
2VBP
DownloadVisualize
BU of 2vbp by Molmil
Isopenicillin N synthase with substrate analogue L,L,L-ACAB (unexposed)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N^6^-[(1R)-2-{[(1S)-1-carboxypropyl]amino}-2-oxo-1-(sulfanylmethyl)ethyl]-6-oxo-L-lysine, ...
Authors:Ge, W, Clifton, I.J, Adlington, R.M, Baldwin, J.E, Rutledge, P.J.
Deposit date:2007-09-14
Release date:2008-11-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystallographic Studies on the Binding of Selectively Deuterated Lld- and Lll-Substrate Epimers by Isopenicillin N Synthase.
Biochem.Biophys.Res.Commun., 398, 2010
1BK0
DownloadVisualize
BU of 1bk0 by Molmil
ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE COMPLEX)
Descriptor: FE (III) ION, ISOPENICILLIN N SYNTHASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ...
Authors:Roach, P.L, Clifton, I.J, Hensgens, C.M.H, Shibata, N, Schofield, C.J, Hajdu, J, Baldwin, J.E.
Deposit date:1998-07-14
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Nature, 387, 1997
1BLZ
DownloadVisualize
BU of 1blz by Molmil
ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (ACV-FE-NO COMPLEX)
Descriptor: FE (III) ION, ISOPENICILLIN N SYNTHASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ...
Authors:Roach, P.L, Clifton, I.J, Hensgens, C.M.H, Shibata, N, Schofield, C.J, Hajdu, J, Baldwin, J.E.
Deposit date:1998-07-22
Release date:1999-01-13
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of isopenicillin N synthase complexed with substrate and the mechanism of penicillin formation.
Nature, 387, 1997
1RXF
DownloadVisualize
BU of 1rxf by Molmil
DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH FE(II)
Descriptor: DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (III) ION
Authors:Valegard, K, Terwisscha Van Scheltinga, A.C, Lloyd, M.D, Hara, T, Ramaswamy, S, Perrakis, A, Thompson, A, Lee, H.J, Baldwin, J.E, Schofield, C.J, Hajdu, J, Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
1RXG
DownloadVisualize
BU of 1rxg by Molmil
DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH FE(II) AND 2-OXOGLUTARATE
Descriptor: 2-OXOGLUTARIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (III) ION, ...
Authors:Valegard, K, Terwisscha Van Scheltinga, A.C, Lloyd, M.D, Hara, T, Ramaswamy, S, Perrakis, A, Thompson, A, Lee, H.J, Baldwin, J.E, Shofield, C.J, Hajdu, J, Andersson, I.
Deposit date:1998-06-05
Release date:1999-06-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of a cephalosporin synthase.
Nature, 394, 1998
1HJG
DownloadVisualize
BU of 1hjg by Molmil
Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258
Descriptor: 3-METHYL-2-OXOBUTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION
Authors:Lee, H.J, Lloyd, M.D, Clifton, I.J, Harlos, K, Dubus, A, Baldwin, J.E, Frere, J.M, Schofield, C.J.
Deposit date:2001-01-15
Release date:2001-06-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258
J.Biol.Chem., 276, 2001
1HJF
DownloadVisualize
BU of 1hjf by Molmil
Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258
Descriptor: 2-OXO-4-METHYLPENTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION
Authors:Lee, H.J, Lloyd, M.D, Clifton, I.J, Harlos, K, Dubus, A, Baldwin, J.E, Frere, J.M, Schofield, C.J.
Deposit date:2001-01-15
Release date:2001-06-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258
J.Biol.Chem., 276, 2001
1IPS
DownloadVisualize
BU of 1ips by Molmil
ISOPENICILLIN N SYNTHASE FROM ASPERGILLUS NIDULANS (MANGANESE COMPLEX)
Descriptor: ISOPENICILLIN N SYNTHASE, MANGANESE (II) ION
Authors:Roach, P.L, Clifton, I.J, Fulop, V, Harlos, K, Barton, G.J, Hajdu, J, Andersson, I, Schofield, C.J, Baldwin, J.E.
Deposit date:1997-03-21
Release date:1998-03-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of isopenicillin N synthase is the first from a new structural family of enzymes.
Nature, 375, 1995
1GQW
DownloadVisualize
BU of 1gqw by Molmil
Taurine/alpha-ketoglutarate Dioxygenase from Escherichia coli
Descriptor: 2-AMINOETHANESULFONIC ACID, 2-OXOGLUTARIC ACID, ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, ...
Authors:Elkins, J.M, Ryle, M.J, Clifton, I.J, Dunning-Hotopp, J.C, Lloyd, J.S, Burzlaff, N.I, Baldwin, J.E, Hausinger, R.P, Roach, P.L.
Deposit date:2001-12-05
Release date:2002-04-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates
Biochemistry, 41, 2002
1GY9
DownloadVisualize
BU of 1gy9 by Molmil
Taurine/alpha-ketoglutarate Dioxygenase from Escherichia coli
Descriptor: 2-AMINOETHANESULFONIC ACID, 2-OXOGLUTARIC ACID, ALPHA-KETOGLUTARATE-DEPENDENT TAURINE DIOXYGENASE, ...
Authors:Elkins, J.M, Burzlaff, N.I, Ryle, M.J, Lloyd, J.S, Clifton, I.J, Baldwin, J.E, Hausinger, R.P, Roach, P.L.
Deposit date:2002-04-22
Release date:2002-04-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:X-Ray Crystal Structure of Escherichia Coli Taurine/Alpha-Ketoglutarate Dioxygenase Complexed to Ferrous Iron and Substrates.
Biochemistry, 41, 2002
2BU9
DownloadVisualize
BU of 2bu9 by Molmil
Isopenicillin N synthase complexed with L-aminoadipoyl-L-cysteinyl-L- hexafluorovaline
Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-L-3,3,3,3',3',3'-HEXAFLUOROVALINE, FE (III) ION, ISOPENICILLIN N SYNTHETASE, ...
Authors:Howard-Jones, A.R, Rutledge, P.J, Clifton, I.J, Adlington, R.M, Baldwin, J.E.
Deposit date:2005-06-09
Release date:2005-09-15
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Unique Binding of a Non-Natural L,L,L-Substrate by Isopenicillin N Synthase
Biochem.Biophys.Res.Commun., 336, 2005
2Y6F
DownloadVisualize
BU of 2y6f by Molmil
Isopenicillin N synthase with AC-D-S-methyl-3R-methylcysteine
Descriptor: (2S)-2-AMINO-6-[[(2R)-1-[[(2S)-1-HYDROXY-3-METHYLSULFANYL-1-OXO-BUTAN-2-YL]AMINO]-1-OXO-3-SULFANYL-PROPAN-2-YL]AMINO]-6-OXO-HEXANOIC ACID, FE (III) ION, ISOPENICILLIN N SYNTHASE, ...
Authors:Rutledge, P.J, Clifton, I.J, Ge, W.
Deposit date:2011-01-21
Release date:2011-08-31
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Isopenicillin N Synthase Binds Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D-Thia-Allo-Isoleucine Through Both Sulfur Atoms.
Chembiochem, 12, 2011
2Y60
DownloadVisualize
BU of 2y60 by Molmil
Isopenicillin N synthase with AC-D-methionine
Descriptor: FE (III) ION, GLYCEROL, ISOPENICILLIN N SYNTHASE, ...
Authors:Rutledge, P.J, Clifton, I.J, Ge, W.
Deposit date:2011-01-19
Release date:2012-02-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The Crystal Structure of Isopenicillin N Synthase with Delta((L)-Alpha-Aminoadipoyl)-(L)-Cysteinyl-(D)-Methionine Reveals Thioether Coordination to Iron.
Arch.Biochem.Biophys., 516, 2011
1W3V
DownloadVisualize
BU of 1w3v by Molmil
Isopenicillin N synthase d-(L-a-aminoadipoyl)-(3R)-methyl-L-cysteine D-a-hydroxyisovaleryl ester complex (anaerobic)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N~6~-METHYL-6-OXO-L-LYSINE - 2-[(3-MERCAPTOBUTANOYL)OXY]-3-METHYLBUTANOIC ACID
Authors:Daruzzaman, A, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-07-20
Release date:2005-12-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Unexpected Oxidation of a Depsipeptide Substrate Analogue in Crystalline Isopenicillin N Synthase.
Chembiochem, 7, 2006
1W3X
DownloadVisualize
BU of 1w3x by Molmil
Isopenicillin N synthase d-(L-a-aminoadipoyl)-(3R)-methyl-L-cysteine D-a-hydroxyisovaleryl ester complex (Oxygen exposed 5 minutes 20 bar)
Descriptor: FE (II) ION, ISOPENICILLIN N SYNTHETASE, N~6~-[(1R)-1-({[(1R,2R)-1-CARBOXY-3-HYDROXY-2-METHYLPROPYL]OXY}CARBONYL)-2-MERCAPTOPROP-2-EN-1-YL]-6-OXO-L-LYSINE
Authors:Daruzzaman, A, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-07-20
Release date:2005-12-07
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Unexpected Oxidation of a Depsipeptide Substrate Analogue in Crystalline Isopenicillin N Synthase.
Chembiochem, 7, 2006
1W04
DownloadVisualize
BU of 1w04 by Molmil
Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Glycine-Fe-NO Complex
Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE, FE (II) ION, HYDROXYAMINE, ...
Authors:Long, A.J, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-06-01
Release date:2005-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Biochemistry, 44, 2005
1W03
DownloadVisualize
BU of 1w03 by Molmil
Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Glycine-Fe Complex
Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-GLYCINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ...
Authors:Long, A.J, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-06-01
Release date:2005-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Biochemistry, 44, 2005
1W05
DownloadVisualize
BU of 1w05 by Molmil
Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Alanine-Fe Complex
Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-ALANINE, FE (II) ION, ISOPENICILLIN N SYNTHETASE, ...
Authors:Long, A.J, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-06-01
Release date:2005-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Biochemistry, 44, 2005
1W06
DownloadVisualize
BU of 1w06 by Molmil
Isopenicillin N Synthase Aminoadipoyl-Cysteinyl-Alanine-Fe NO Complex
Descriptor: DELTA-(L-ALPHA-AMINOADIPOYL)-L-CYSTEINYL-D-ALANINE, FE (II) ION, HYDROXYAMINE, ...
Authors:Long, A.J, Clifton, I.J, Rutledge, P.J.
Deposit date:2004-06-01
Release date:2005-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Studies on the Reaction of Isopenicillin N Synthase with the Truncated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-Glycine and Delta-(L-Alpha-Aminoadipoyl)-L-Cysteinyl-D- Alanine
Biochemistry, 44, 2005
3ZKY
DownloadVisualize
BU of 3zky by Molmil
Isopenicillin N synthase with substrate analogue AhCmC
Descriptor: FE (III) ION, GLYCEROL, ISOPENICILLIN N SYNTHASE, ...
Authors:Daruzzaman, A, Clifton, I.J, Rutledge, P.J.
Deposit date:2013-01-25
Release date:2013-03-20
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Interaction of Isopenicillin N Synthase with Homologated Substrate Analogues Delta-(L-Alpha-Aminoadipoyl)-L-Homocysteinyl-D-Xaa Characterised by Protein Crystallography.
Chembiochem, 14, 2013

227111

數據於2024-11-06公開中

PDB statisticsPDBj update infoContact PDBjnumon