1S2Q
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![BU of 1s2q by Molmil](/molmil-images/mine/1s2q) | Crystal structure of MAOB in complex with N-propargyl-1(R)-aminoindan (Rasagiline) | Descriptor: | (1R)-N-(prop-2-en-1-yl)-2,3-dihydro-1H-inden-1-amine, Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A. | Deposit date: | 2004-01-09 | Release date: | 2004-03-30 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47, 2004
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1S2Y
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![BU of 1s2y by Molmil](/molmil-images/mine/1s2y) | Crystal structure of MAOB in complex with N-propargyl-1(S)-aminoindan | Descriptor: | Amine oxidase [flavin-containing] B, FLAVIN-ADENINE DINUCLEOTIDE, N-PROPARGYL-1(S)-AMINOINDAN | Authors: | Binda, C, Hubalek, F, Li, M, Herzig, Y, Sterling, J, Edmondson, D.E, Mattevi, A. | Deposit date: | 2004-01-12 | Release date: | 2004-03-30 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Crystal Structures of Monoamine Oxidase B in Complex with Four Inhibitors of the N-Propargylaminoindan Class. J.Med.Chem., 47, 2004
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5O0X
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![BU of 5o0x by Molmil](/molmil-images/mine/5o0x) | Crystal structure of dehydrogenase domain of Cylindrospermum stagnale NADPH-Oxidase 5 (NOX5) | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Magnani, F, Nenci, S, Mattevi, A. | Deposit date: | 2017-05-17 | Release date: | 2017-06-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures and atomic model of NADPH oxidase. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5O0T
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![BU of 5o0t by Molmil](/molmil-images/mine/5o0t) | CRYSTAL STRUCTURE OF TRANS-MEMBRANE DOMAIN OF Cylindrospermum stagnale NADPH-OXIDASE 5 (NOX5) | Descriptor: | DECANE, DI(HYDROXYETHYL)ETHER, EICOSANE, ... | Authors: | Magnani, F, Nenci, S, Mattevi, A. | Deposit date: | 2017-05-17 | Release date: | 2017-06-28 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystal structures and atomic model of NADPH oxidase. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1GOS
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![BU of 1gos by Molmil](/molmil-images/mine/1gos) | Human Monoamine Oxidase B | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, MONOAMINE OXIDASE, N-[(E)-METHYL](PHENYL)-N-[(E)-2-PROPENYLIDENE]METHANAMINIUM | Authors: | Binda, C, Newton-Vinson, P, Hubalek, F, Edmondson, D.E, Mattevi, A. | Deposit date: | 2001-10-26 | Release date: | 2001-11-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Human Monoamine Oxidase B, a Drug Target for the Treatment of Neurological Disorders Nat.Struct.Biol., 9, 2001
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8BAM
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![BU of 8bam by Molmil](/molmil-images/mine/8bam) | Eugenol Oxidase (EUGO) from Rhodococcus jostii RHA1, tenfold mutant active on propanol syringol | Descriptor: | 2,6-dimethoxy-4-(3-oxidanylpropyl)phenol, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | Authors: | Alvigini, L, Mattevi, A. | Deposit date: | 2022-10-11 | Release date: | 2023-10-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | One-Pot Biocatalytic Synthesis of rac -Syringaresinol from a Lignin-Derived Phenol. Acs Catalysis, 13, 2023
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8BAP
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![BU of 8bap by Molmil](/molmil-images/mine/8bap) | Eugenol Oxidase (EUGO) from Rhodococcus jostii RHA1, eightfold mutant active on propanol syringol | Descriptor: | 4-[(1E)-3-hydroxyprop-1-en-1-yl]-2,6-dimethoxyphenol, CALCIUM ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Alvigini, L, Mattevi, A. | Deposit date: | 2022-10-11 | Release date: | 2023-10-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | One-Pot Biocatalytic Synthesis of rac -Syringaresinol from a Lignin-Derived Phenol. Acs Catalysis, 13, 2023
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8BOX
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![BU of 8box by Molmil](/molmil-images/mine/8box) | LSD1-CoREST in complex with AW4 and SNAG peptide | Descriptor: | Lysine-specific histone demethylase 1A, REST corepressor 1, Zinc finger protein SNAI1, ... | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2022-11-15 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.82 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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8BOP
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![BU of 8bop by Molmil](/molmil-images/mine/8bop) | LSD1-CoREST in complex with AW4, long soaking | Descriptor: | Lysine-specific histone demethylase 1A, REST corepressor 1, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(2~{R},3~{S},4~{S})-5-[7,8-dimethyl-2,4-bis(oxidanylidene)-5-[3-[4-(3-phenylphenyl)phenyl]propanoyl]-1~{H}-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentyl] hydrogen phosphate | Authors: | Caroli, J, Mattevi, A. | Deposit date: | 2022-11-15 | Release date: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Distal drug resistance mutations promote covalent inhibitor-adduct Grob fragmentation in LSD1 to be published
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4AUT
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![BU of 4aut by Molmil](/molmil-images/mine/4aut) | Crystal structure of the tuberculosis drug target Decaprenyl- Phosphoryl-beta-D-Ribofuranose-2-oxidoreductase (DprE1) from Mycobacterium smegmatis | Descriptor: | DECAPRENYL-PHOSPHORYL-BETA-D-RIBOFURANOSE-2-OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Neres, J, Pojer, F, Molteni, E, Chiarelli, L.R, Dhar, N, Boy-Rottger, S, Buroni, S, Fullam, E, Degiacomi, G, Lucarelli, A, Read, R.J, Zanoni, G, Edmondson, D.E, De Rossi, E, Pasca, M, Riccardi, G, Mattevi, A, Dyson, P.J, Cole, S.T, Binda, C. | Deposit date: | 2012-05-21 | Release date: | 2012-09-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium Tuberculosis. Sci. Transl. Med., 4, 2012
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1E0T
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![BU of 1e0t by Molmil](/molmil-images/mine/1e0t) | |
1E0U
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![BU of 1e0u by Molmil](/molmil-images/mine/1e0u) | |
4D03
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![BU of 4d03 by Molmil](/molmil-images/mine/4d03) | Structure of the Cys65Asp mutant of phenylacetone monooxygenase: oxidised state | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, HEXAETHYLENE GLYCOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Brondani, P.B, Dudek, H.M, Martinoli, C, Mattevi, A, Fraaije, M.W. | Deposit date: | 2014-04-24 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Finding the Switch: Turning a Baeyer-Villiger Monooxygenase Into a Nadph Oxidase. J.Am.Chem.Soc., 136, 2014
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6SEM
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![BU of 6sem by Molmil](/molmil-images/mine/6sem) | Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 2 | Descriptor: | Ancestral Flavin-containing monooxygenase (FMO) 2, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Nicoll, C, Bailleul, G, Fiorentini, F, Mascotti, M.L, Fraaije, M, Mattevi, A. | Deposit date: | 2019-07-30 | Release date: | 2019-12-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nat.Struct.Mol.Biol., 27, 2020
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6SF0
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![BU of 6sf0 by Molmil](/molmil-images/mine/6sf0) | Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 2 in the presence of NADP+ | Descriptor: | Ancestral Flavin-containing monooxygenase (FMO) 2, CYCLOHEXYL-HEXYL-BETA-D-MALTOSIDE, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Nicoll, C, Bailleul, G, Fiorentini, F, Mascotti, M.L, Fraaije, M, Mattevi, A. | Deposit date: | 2019-07-30 | Release date: | 2019-12-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nat.Struct.Mol.Biol., 27, 2020
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6SEK
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![BU of 6sek by Molmil](/molmil-images/mine/6sek) | Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 5 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Ancestral Flavin-containing monooxygenase 5, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Nicoll, C, Bailleul, G, Fiorentini, F, Mascotti, M.L, Fraaije, M, Mattevi, A. | Deposit date: | 2019-07-30 | Release date: | 2019-12-25 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nat.Struct.Mol.Biol., 27, 2020
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4C77
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![BU of 4c77 by Molmil](/molmil-images/mine/4c77) | Phenylacetone monooxygenase: oxidised R337K mutant in complex with APADP | Descriptor: | 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, HEXAETHYLENE GLYCOL, ... | Authors: | Martinoli, C, Fraaije, M.W, Mattevi, A. | Deposit date: | 2013-09-19 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. Acs Catal., 3, 2013
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4D7E
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![BU of 4d7e by Molmil](/molmil-images/mine/4d7e) | An unprecedented NADPH domain conformation in Lysine Monooxygenase NbtG from Nocardia farcinica | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, L-LYS MONOOXYGENASE | Authors: | Binda, C, Robinson, R, Keul, N, Rodriguez, P, Robinson, H.H, Mattevi, A, Sobrado, P. | Deposit date: | 2014-11-24 | Release date: | 2015-04-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | An Unprecedented Nadph Domain Conformation in Lysine Monooxygenase Nbtg Provides Insights Into Uncoupling of Oxygen Consumption from Substrate Hydroxylation. J.Biol.Chem., 290, 2015
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6SE3
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![BU of 6se3 by Molmil](/molmil-images/mine/6se3) | Crystal Structure of Ancestral Flavin-containing monooxygenase (FMO) 3-6 | Descriptor: | Ancestral Flavin-containing monooxygenase (FMO) 3-6, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Nicoll, C, Bailleul, G, Fiorentini, F, Mascotti, M.L, Fraaije, M, Mattevi, A. | Deposit date: | 2019-07-29 | Release date: | 2019-12-25 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Ancestral-sequence reconstruction unveils the structural basis of function in mammalian FMOs. Nat.Struct.Mol.Biol., 27, 2020
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4F4Q
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![BU of 4f4q by Molmil](/molmil-images/mine/4f4q) | Crystal structure of M. smegmatis DprE1 in complex with FAD and covalently bound BTZ043 | Descriptor: | 8-(hydroxyamino)-2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one, DprE1, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Neres, J, Pojer, F, Molteni, E, Chiarelli, L, Riccardi, G, Mattevi, A, Cole, S.T, Binda, C. | Deposit date: | 2012-05-11 | Release date: | 2012-09-05 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.619 Å) | Cite: | Structural Basis for Benzothiazinone-Mediated Killing of Mycobacterium tuberculosis. Sci Transl Med, 4, 2012
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6H3O
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![BU of 6h3o by Molmil](/molmil-images/mine/6h3o) | Alcohol oxidase from Phanerochaete chrysosporium mutant F101S | Descriptor: | Alcohol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL | Authors: | Nguyen, Q.-T, Romero, E, Dijkman, W.P, de Vasconcellos, S.P, Binda, C, Mattevi, A, Fraaije, M.W. | Deposit date: | 2018-07-19 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. Biochemistry, 57, 2018
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4C74
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![BU of 4c74 by Molmil](/molmil-images/mine/4c74) | Phenylacetone monooxygenase: Reduced enzyme in complex with APADP | Descriptor: | 3-ACETYLPYRIDINE ADENINE DINUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, HEXAETHYLENE GLYCOL, ... | Authors: | Martinoli, C, Fraaije, M.W, Mattevi, A. | Deposit date: | 2013-09-19 | Release date: | 2014-02-05 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Beyond the Protein Matrix: Probing Cofactor Variants in a Baeyer-Villiger Oxygenation Reaction. Acs Catal., 3, 2013
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3GUR
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![BU of 3gur by Molmil](/molmil-images/mine/3gur) | Crystal Structure of mu class glutathione S-transferase (GSTM2-2) in complex with glutathione and 6-(7-Nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol (NBDHEX) | Descriptor: | 1,2-ETHANEDIOL, GLUTATHIONE, Glutathione S-transferase Mu 2, ... | Authors: | Federici, L, Lo Sterzo, C, Di Matteo, A, Scaloni, F, Federici, G, Caccuri, A.M. | Deposit date: | 2009-03-30 | Release date: | 2009-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for the binding of the anticancer compound 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio)hexanol to human glutathione s-transferases Cancer Res., 69, 2009
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6H3G
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![BU of 6h3g by Molmil](/molmil-images/mine/6h3g) | Alcohol oxidase from Phanerochaete chrysosporium | Descriptor: | Alcohol oxidase, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL | Authors: | Nguyen, Q.-T, Romero, E, Dijkman, W.P, de Vasconcellos, S.P, Binda, C, Mattevi, A, Fraaije, M.W. | Deposit date: | 2018-07-18 | Release date: | 2018-10-10 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Based Engineering of Phanerochaete chrysosporium Alcohol Oxidase for Enhanced Oxidative Power toward Glycerol. Biochemistry, 57, 2018
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4CZZ
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![BU of 4czz by Molmil](/molmil-images/mine/4czz) | Histone demethylase LSD1(KDM1A)-CoREST3 Complex | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 3 | Authors: | Barrios, A.P, Gomez, A.V, Saez, J.E, Ciossani, G, Toffolo, E, Battaglioli, E, Mattevi, A, Andres, M.E. | Deposit date: | 2014-04-23 | Release date: | 2014-06-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Differential Properties of Transcriptional Complexes Formed by the Corest Family. Mol.Cell.Biol., 34, 2014
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