8PWK
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![BU of 8pwk by Molmil](/molmil-images/mine/8pwk) | human HINT1 in complex with compound AT8003 | Descriptor: | Histidine triad nucleotide-binding protein 1, SODIUM ION, [(2~{R},3~{R},4~{R},5~{R})-5-[2-azanyl-6-(methylamino)purin-9-yl]-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Zimberger, C, Canard, B, Ferron, F. | Deposit date: | 2023-07-20 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Plos Biol., 2024
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8QCH
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![BU of 8qch by Molmil](/molmil-images/mine/8qch) | |
8PTS
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![BU of 8pts by Molmil](/molmil-images/mine/8pts) | human GUK1 in complex with compound AT8001 | Descriptor: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Zimberger, C, Canard, B, Ferron, F. | Deposit date: | 2023-07-14 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural and functional basis for metabolic activation of the antiviral drug Bemnifosbuvir To Be Published
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6ZPP
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![BU of 6zpp by Molmil](/molmil-images/mine/6zpp) | |
8PHZ
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![BU of 8phz by Molmil](/molmil-images/mine/8phz) | Helical reconstruction of CHIKV nsP3 helical scaffolds | Descriptor: | Non-structural protein 3, ZINC ION | Authors: | Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A. | Deposit date: | 2023-06-20 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | The alphavirus nsP3 protein forms helical tubular scaffolds important for viral replication and particle assembly To be published
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8PK7
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![BU of 8pk7 by Molmil](/molmil-images/mine/8pk7) | Helical reconstruction of CHIKV nsP3 helical scaffolds | Descriptor: | Non-structural protein 3, ZINC ION | Authors: | Reguera, J, Hons, M, Zimberger, C, Ptchelkine, D, Jones, R, Desfosses, A. | Deposit date: | 2023-06-25 | Release date: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | The alphavirus nsP3 protein forms helical tubular scaffolds important for viral replication and particle assembly To Be Published
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8PIE
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![BU of 8pie by Molmil](/molmil-images/mine/8pie) | Crystal structure of the human nucleoside diphosphate kinase B domain in complex with the product AT-8500 formed by catalysis of compound AT-9010 | Descriptor: | GLYCEROL, Nucleoside diphosphate kinase B, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl phosphono hydrogen phosphate | Authors: | Feracci, M, Chazot, A, Ferron, F, Alvarez, K, Canard, B. | Deposit date: | 2023-06-21 | Release date: | 2024-07-31 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution Plos Biol., 2024
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6RJD
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![BU of 6rjd by Molmil](/molmil-images/mine/6rjd) | Cryo-EM structure of St1Cas9-sgRNA-tDNA59-ntPAM complex. | Descriptor: | Streptococcus Thermophilus 1 Cas9, ntPAM, sgRNA (78-MER), ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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6RJG
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![BU of 6rjg by Molmil](/molmil-images/mine/6rjg) | Cryo-EM structure of St1Cas9-sgRNA-AcrIIA6-tDNA59-ntPAM complex. | Descriptor: | AcrIIA6, Cas 9, ntPAM, ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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6RJA
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![BU of 6rja by Molmil](/molmil-images/mine/6rja) | Cryo-EM structure of St1Cas9-sgRNA-tDNA20-AcrIIA6 dimeric assembly. | Descriptor: | AcrIIA6, CRISPR-associated endonuclease Cas9 1, RNA (78-MER), ... | Authors: | Goulet, A, Cambillau, C, Chaves-Sanjuan, A. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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6RJ9
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![BU of 6rj9 by Molmil](/molmil-images/mine/6rj9) | Cryo-EM structure of St1Cas9-sgRNA-tDNA20-AcrIIA6 monomeric assembly. | Descriptor: | AcrIIA6, CRISPR-associated endonuclease Cas9 1, sgRNA, ... | Authors: | Goulet, A, Chaves-Sanjuan, A, Cambillau, C. | Deposit date: | 2019-04-26 | Release date: | 2019-10-02 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6. Mol.Cell, 76, 2019
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