6FNE
 
 | | Structure of human Brag2 (Sec7-PH domains) with the inhibitor Bragsin bound to the PH domain | | Descriptor: | (2~{S})-6-methyl-5-nitro-2-(trifluoromethyl)-2,3-dihydrochromen-4-one, IQ motif and SEC7 domain-containing protein 1, NONAETHYLENE GLYCOL | | Authors: | Nawrotek, A, Zeghouf, M, Cherfils, J. | | Deposit date: | 2018-02-03 | | Release date: | 2019-03-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.501 Å) | | Cite: | PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling.
Nat.Chem.Biol., 15, 2019
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1DDI
 | | CRYSTAL STRUCTURE OF SIR-FP60 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, SULFITE REDUCTASE [NADPH] FLAVOPROTEIN ALPHA-COMPONENT | | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | | Deposit date: | 1999-11-10 | | Release date: | 2000-11-13 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
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1DDG
 | | CRYSTAL STRUCTURE OF SIR-FP60 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, SULFITE REDUCTASE (NADPH) FLAVOPROTEIN ALPHA-COMPONENT | | Authors: | Gruez, A, Pignol, D, Zeghouf, M, Coves, J, Fontecave, M, Ferrer, J.L, Fontecilla-Camps, J.C. | | Deposit date: | 1999-11-10 | | Release date: | 2000-11-13 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Four crystal structures of the 60 kDa flavoprotein monomer of the sulfite reductase indicate a disordered flavodoxin-like module.
J.Mol.Biol., 299, 2000
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4AII
 | | Crystal structure of the rat REM2 GTPase - G domain bound to GDP | | Descriptor: | GTP-BINDING PROTEIN REM 2, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Reymond, P, Coquard, A, Chenon, M, Zeghouf, M, El Marjou, A, Thompson, A, Menetrey, J. | | Deposit date: | 2012-02-10 | | Release date: | 2012-06-13 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.66 Å) | | Cite: | Structure of the Gdp-Bound G Domain of the Rgk Protein Rem2.
Acta Crystallogr.,Sect.F, 68, 2012
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4C7P
 | | Crystal structure of Legionella pneumophila RalF F255K mutant | | Descriptor: | GLYCEROL, RALF | | Authors: | Folly-Klan, M, Alix, E, Stalder, D, Ray, P, Duarte, L.V, Delprato, A, Zeghouf, M, Antonny, B, Campanacci, V, Roy, C.R, Cherfils, J. | | Deposit date: | 2013-09-24 | | Release date: | 2013-12-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | A Novel Membrane Sensor Controls the Localization and Arfgef Activity of Bacterial Ralf.
Plos Pathog., 9, 2013
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4C0A
 | | Arf1(Delta1-17)in complex with BRAG2 Sec7-PH domain | | Descriptor: | ADP-RIBOSYLATION FACTOR 1, GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE, IQ MOTIF AND SEC7 DOMAIN-CONTAINING PROTEIN 1 | | Authors: | Aizel, K, Biou, V, Navaza, J, Duarte, L, Campanacci, V, Cherfils, J, Zeghouf, M. | | Deposit date: | 2013-08-01 | | Release date: | 2013-09-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
PLoS Biol., 11, 2013
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6H7E
 | | GEF regulatory domain | | Descriptor: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, SULFATE ION, cDNA FLJ56134, ... | | Authors: | Ferrandez, Y, Cherfils, J, Peurois, F. | | Deposit date: | 2018-07-31 | | Release date: | 2020-02-19 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Membranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Nat Commun, 14, 2023
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6U3G
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6U3E
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3N5C
 | | Crystal Structure of Arf6DELTA13 complexed with GDP | | Descriptor: | ADP-ribosylation factor 6, CHLORIDE ION, GUANOSINE-5'-DIPHOSPHATE | | Authors: | Aizel, K, Biou, V, Cherfils, J. | | Deposit date: | 2010-05-25 | | Release date: | 2010-08-18 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | SAXS and X-ray crystallography suggest an unfolding model for the GDP/GTP conformational switch of the small GTPase Arf6.
J.Mol.Biol., 402, 2010
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5N6O
 | | Wild type human Rac1-GDP | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related C3 botulinum toxin substrate 1 | | Authors: | Cherfils, J, Ferrandez, Y. | | Deposit date: | 2017-02-15 | | Release date: | 2017-12-27 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Allosteric inhibition of the guanine nucleotide exchange factor DOCK5 by a small molecule.
Sci Rep, 7, 2017
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