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Crystal structure of SARS-CoV-2 RBD in complex with a neutralizing antibody Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1, antibody heavy chain, ...
Authors:	Guo, Y, Li, X, Zhang, G, Fu, D, Schweizer, L, Zhang, H, Rao, Z.
Deposit date:	2020-07-10
Release date:	2020-11-11
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.108 Å)
Cite:	A SARS-CoV-2 neutralizing antibody with extensive Spike binding coverage and modified for optimal therapeutic outcomes. Nat Commun, 12, 2021

X-ray co-crystal structure of NCGC00685960 / NCATS-SM9335 in NNMT
Descriptor:	(8M)-8-{3-[(3S)-1-(2-cyclohexylethyl)piperidin-3-yl]-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl}quinolin-2(1H)-one, Nicotinamide N-methyltransferase
Authors:	Olland, A, White, A, Suto, R.
Deposit date:	2024-02-27
Release date:	2025-03-05
Method:	X-RAY DIFFRACTION (2.413 Å)
Cite:	NNMT inhibition blocks cancer-associated fibroblast-mediated immunosuppressi on To Be Published

X-ray crystal structure of human FXA in complex with 6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide
Descriptor:	6-chloro-N-((3S)-2-oxo-1-(2-oxo-2-((5S)-8-oxo-5,6-dihydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocin-3(2H,4H,8H)-yl)ethyl)piperidin-3-yl)naphthalene-2-sulfonamide, CALCIUM ION, Coagulation factor X, ...
Authors:	Klei, H.E.
Deposit date:	2011-07-13
Release date:	2011-11-16
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.42 Å)
Cite:	Arylsulfonamidopiperidone derivatives as a novel class of factor Xa inhibitors. Bioorg.Med.Chem.Lett., 21, 2011