1FLI
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![BU of 1fli by Molmil](/molmil-images/mine/1fli) | DNA-BINDING DOMAIN OF FLI-1 | Descriptor: | FLI-1 | Authors: | Liang, H, Mao, X, Olejniczak, E.T, Nettesheim, D.G, Yu, L, Meadows, R.P, Thompson, C.B, Fesik, S.W. | Deposit date: | 1994-09-15 | Release date: | 1995-09-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the ets domain of Fli-1 when bound to DNA. Nat.Struct.Biol., 1, 1994
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2KI0
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![BU of 2ki0 by Molmil](/molmil-images/mine/2ki0) | NMR Structure of a de novo designed beta alpha beta | Descriptor: | DS119 | Authors: | Liang, H, Chen, H, Fan, K, Wei, P, Guo, X, Jin, C, Zeng, C, Tang, C, Lai, L. | Deposit date: | 2009-04-18 | Release date: | 2009-10-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | De novo design of a beta alpha beta motif. Angew.Chem.Int.Ed.Engl., 48, 2009
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1DHM
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![BU of 1dhm by Molmil](/molmil-images/mine/1dhm) | DNA-BINDING DOMAIN OF E2 FROM HUMAN PAPILLOMAVIRUS-31, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | E2 PROTEIN | Authors: | Liang, H, Petros, A.P, Meadows, R.P, Yoon, H.S, Egan, D.A, Walter, K, Holzman, T.F, Robins, T, Fesik, S.W. | Deposit date: | 1995-08-15 | Release date: | 1996-12-07 | Last modified: | 2024-04-10 | Method: | SOLUTION NMR | Cite: | Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA-binding regions. Biochemistry, 35, 1996
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8IM0
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![BU of 8im0 by Molmil](/molmil-images/mine/8im0) | mCherry-LaM8 complex | Descriptor: | LaM8, MCherry fluorescent protein | Authors: | Liang, H, Liu, R, Ding, Y. | Deposit date: | 2023-03-05 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8ILX
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![BU of 8ilx by Molmil](/molmil-images/mine/8ilx) | mCherry-LaM3 complex | Descriptor: | LAM3, MCherry fluorescent protein | Authors: | Liang, H, Liu, R, Ding, Y. | Deposit date: | 2023-03-05 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8IM1
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![BU of 8im1 by Molmil](/molmil-images/mine/8im1) | mCherry-LaM1 complex | Descriptor: | LaM1, MCherry fluorescent protein, SULFATE ION | Authors: | Liang, H, Liu, R, Ding, Y. | Deposit date: | 2023-03-05 | Release date: | 2023-06-21 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structural Insights into the Binding of Red Fluorescent Protein mCherry-Specific Nanobodies. Int J Mol Sci, 24, 2023
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8HJB
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![BU of 8hjb by Molmil](/molmil-images/mine/8hjb) | Crystal structure of Pseudomonas aeruginosa PvrA with coenzyme A | Descriptor: | COENZYME A, TetR family transcriptional regulator | Authors: | Liang, H, Bartlam, M. | Deposit date: | 2022-11-23 | Release date: | 2023-02-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. Nucleic Acids Res., 51, 2023
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7Y0Z
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![BU of 7y0z by Molmil](/molmil-images/mine/7y0z) | Crystal structure of Pseudomonas aeruginosa PvrA | Descriptor: | TetR family transcriptional regulator | Authors: | Liang, H, Zhang, Q, Bartlam, M. | Deposit date: | 2022-06-06 | Release date: | 2023-02-08 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. Nucleic Acids Res., 51, 2023
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7Y0Y
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![BU of 7y0y by Molmil](/molmil-images/mine/7y0y) | Crystal structure of Pseudomonas aeruginosa PvrA (SeMet) | Descriptor: | TetR family transcriptional regulator | Authors: | Liang, H, Zhang, Q, Bartlam, M. | Deposit date: | 2022-06-06 | Release date: | 2023-02-08 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Regulatory and structural mechanisms of PvrA-mediated regulation of the PQS quorum-sensing system and PHA biosynthesis in Pseudomonas aeruginosa. Nucleic Acids Res., 51, 2023
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8H69
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![BU of 8h69 by Molmil](/molmil-images/mine/8h69) | Cryo-EM structure of influenza RNA polymerase | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(*UP*AP*AP*AP*CP*UP*CP*CP*UP*GP*CP*UP*UP*UP*UP*GP*CP*U)-3'), ... | Authors: | Li, H, Wu, Y, Liang, H, Liu, Y. | Deposit date: | 2022-10-16 | Release date: | 2023-06-28 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | An intermediate state allows influenza polymerase to switch smoothly between transcription and replication cycles. Nat.Struct.Mol.Biol., 30, 2023
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1PYN
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![BU of 1pyn by Molmil](/molmil-images/mine/1pyn) | DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE | Descriptor: | 2-(4-{2-TERT-BUTOXYCARBONYLAMINO-2-[4-(3-HYDROXY-2-METHOXYCARBONYL-PHENOXY)-BUTYLCARBAMOYL]-ETHYL}-PHENOXY)-MALONIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Zhonghua, P, Lubben, T, Trevillyan, J.M, Stashko, M, Ballaron, S.J, Liang, H. | Deposit date: | 2003-07-09 | Release date: | 2003-09-16 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Discovery and SAR of novel, potent and selective protein tyrosine phosphatase 1B inhibitors. Bioorg.Med.Chem.Lett., 13, 2003
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1ONY
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![BU of 1ony by Molmil](/molmil-images/mine/1ony) | Oxalyl-Aryl-Amino Benzoic Acid inhibitors of PTP1B, compound 17 | Descriptor: | 2-{[2-(2-CARBAMOYL-VINYL)-4-(2-METHANESULFONYLAMINO-2-PENTYLCARBAMOYL-ETHYL)-PHENYL]-OXALYL-AMINO}-BENZOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Liu, G, Szczepankiewicz, B.G, Pei, Z, Janowich, D.A, Xin, Z, Hadjuk, P.J, Abad-Zapatero, C, Liang, H, Hutchins, C.W, Fesik, S.W, Ballaron, S.J, Stashko, M.A, Lubben, T, Mika, A.K, Zinker, B.A, Trevillyan, J.M, Jirousek, M.R. | Deposit date: | 2003-03-02 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic
Acids as Inhibitors of Protein Tyrosine Phosphatase 1B J.Med.Chem., 46, 2003
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1BXL
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![BU of 1bxl by Molmil](/molmil-images/mine/1bxl) | STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE | Descriptor: | BAK PEPTIDE, BCL-XL | Authors: | Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W. | Deposit date: | 1996-10-16 | Release date: | 1997-10-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis. Science, 275, 1997
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1ONZ
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![BU of 1onz by Molmil](/molmil-images/mine/1onz) | Oxalyl-aryl-Amino Benzoic acid Inhibitors of PTP1B, compound 8b | Descriptor: | 2-[(7-HYDROXY-NAPHTHALEN-1-YL)-OXALYL-AMINO]-BENZOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Liu, G, Szczepankiewicz, B.G, Pei, Z, Janowich, D.A, Xin, Z, Hadjuk, P.J, Abad-Zapatero, C, Liang, H, Hutchins, C.W, Fesik, S.W, Ballaron, S.J, Stashko, M.A, Lubben, T, Mika, A.K, Zinker, B.A, Trevillyan, J.M, Jirousek, M.R. | Deposit date: | 2003-03-02 | Release date: | 2003-05-20 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery and Structure-Activity Relationship of Oxalylarylaminobenzoic
Acids as Inhibitors of Protein Tyrosine Phosphatase 1B J.Med.Chem., 46, 2003
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5J2Y
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![BU of 5j2y by Molmil](/molmil-images/mine/5j2y) | Molecular insight into the regulatory mechanism of the quorum-sensing repressor RsaL in Pseudomonas aeruginosa | Descriptor: | DNA (26-MER), Regulatory protein | Authors: | Zhao, J, Gan, J, Zhang, J, Kang, H, Kong, W, Zhu, M, Li, F, Song, Y, Qin, J, Liang, H. | Deposit date: | 2016-03-30 | Release date: | 2017-04-12 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structure of Pseudomonas aeruginosa RsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing. Nucleic Acids Res., 45, 2017
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5I5O
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![BU of 5i5o by Molmil](/molmil-images/mine/5i5o) | |
5I5N
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![BU of 5i5n by Molmil](/molmil-images/mine/5i5n) | |
4WJA
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![BU of 4wja by Molmil](/molmil-images/mine/4wja) | Crystal Structure of PAXX | Descriptor: | Uncharacterized protein C9orf142 | Authors: | Xing, M, Yang, M, Huo, W, Feng, F, Wei, L, Ning, S, Yan, Z, Li, W, Wang, Q, Hou, M, Dong, C, Guo, R, Gao, G, Ji, J, Lan, L, Liang, H, Xu, D. | Deposit date: | 2014-09-29 | Release date: | 2015-03-11 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway. Nat Commun, 6, 2015
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1MAZ
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![BU of 1maz by Molmil](/molmil-images/mine/1maz) | X-RAY STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH | Descriptor: | Bcl-2-like protein 1 | Authors: | Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W. | Deposit date: | 1996-04-09 | Release date: | 1997-04-21 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature, 381, 1996
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1LXL
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![BU of 1lxl by Molmil](/molmil-images/mine/1lxl) | NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE | Descriptor: | BCL-XL | Authors: | Muchmore, S.W, Sattler, M, Liang, H, Meadows, R.P, Harlan, J.E, Yoon, H.S, Nettesheim, D, Chang, B.S, Thompson, C.B, Wong, S.L, Ng, S.C, Fesik, S.W. | Deposit date: | 1996-04-04 | Release date: | 1997-04-21 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Nature, 381, 1996
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4EFO
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![BU of 4efo by Molmil](/molmil-images/mine/4efo) | Crystal structure of the ubiquitin-like domain of human TBK1 | Descriptor: | Serine/threonine-protein kinase TBK1 | Authors: | Li, J, Li, J, Miyahira, A, Sun, J, Liu, Y, Cheng, G, Liang, H. | Deposit date: | 2012-03-30 | Release date: | 2012-06-27 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.769 Å) | Cite: | Crystal structure of the ubiquitin-like domain of human TBK1. Protein Cell, 3, 2012
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4G1T
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![BU of 4g1t by Molmil](/molmil-images/mine/4g1t) | Crystal structure of interferon-stimulated gene 54 | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 2 | Authors: | Yang, Z, Liang, H, Zhou, Q, Li, Y, Chen, H, Ye, W, Chen, D, Fleming, J, Shu, H, Liu, Y. | Deposit date: | 2012-07-11 | Release date: | 2012-08-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms. Cell Res., 22, 2012
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1PH0
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![BU of 1ph0 by Molmil](/molmil-images/mine/1ph0) | Non-carboxylic Acid-Containing Inhibitor of PTP1B Targeting the Second Phosphotyrosine Site | Descriptor: | 2-{4-[2-(S)-ALLYLOXYCARBONYLAMINO-3-{4-[(2-CARBOXY-PHENYL)-OXALYL-AMINO]-PHENYL}-PROPIONYLAMINO]-BUTOXY}-6-HYDROXY-BENZ OIC ACID METHYL ESTER, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Liu, G, Xin, Z, Liang, H, Abad-Zapatero, C, Hajduk, P, Janowick, D, Szczepankiewicz, B, Pei, Z, Hutchins, C.W, Ballaron, S.J. | Deposit date: | 2003-05-29 | Release date: | 2003-07-29 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Selective Protein Tyrosine Phosphatase 1B Inhibitors: Targeting the Second Phosphotyrosine Binding Site with Non-Carboxylic Acid-Containing Ligands. J.Med.Chem., 46, 2003
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1NO6
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![BU of 1no6 by Molmil](/molmil-images/mine/1no6) | Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 5 Using a Linked-Fragment Strategy | Descriptor: | 2-[(CARBOXYCARBONYL)(1-NAPHTHYL)AMINO]BENZOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Pei, Z, Xin, Z, Lubben, T, Trevillyan, J.M, Stashko, M.A, Ballaron, S.J, Liang, H, Huang, F, Hutchins, C.W, Fesik, S.W, Jirousek, M.R. | Deposit date: | 2003-01-15 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor
Using a Linked-Fragment Strategy J.Am.Chem.Soc., 125, 2003
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1NNY
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![BU of 1nny by Molmil](/molmil-images/mine/1nny) | Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Compound 23 Using a Linked-Fragment Strategy | Descriptor: | 3-({5-[(N-ACETYL-3-{4-[(CARBOXYCARBONYL)(2-CARBOXYPHENYL)AMINO]-1-NAPHTHYL}-L-ALANYL)AMINO]PENTYL}OXY)-2-NAPHTHOIC ACID, Protein-tyrosine phosphatase, non-receptor type 1 | Authors: | Szczepankiewicz, B.G, Liu, G, Hajduk, P.J, Abad-Zapatero, C, Pei, Z, Xin, Z, Lubben, T, Trevillyan, J.M, Stashko, M.A, Ballaron, S.J, Liang, H, Huang, F, Hutchins, C.W, Fesik, S.W, Jirousek, M.R. | Deposit date: | 2003-01-14 | Release date: | 2003-04-08 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor
Using a Linked-Fragment Strategy J.Am.Chem.Soc., 125, 2003
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