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Crystal structure of BCX7353(ORLADEYO) in complex with human plasma kallikrein serine protease domain at 2.1 angstrom resolution
Descriptor:	Orladeyo, PHOSPHATE ION, Plasma kallikrein light chain
Authors:	Krishnan, R, Yarlagadda, B.S, Kotian, P, Polach, K.J, Zhang, W.
Deposit date:	2021-06-11
Release date:	2021-09-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.097 Å)
Cite:	Berotralstat (BCX7353): Structure-Guided Design of a Potent, Selective, and Oral Plasma Kallikrein Inhibitor to Prevent Attacks of Hereditary Angioedema (HAE). J.Med.Chem., 64, 2021

Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor:	1-[(3-acetylphenyl)acetyl]-N-(6-bromopyridin-2-yl)-L-prolinamide, Complement factor D, GLYCEROL
Authors:	Raman, K, Babu, Y.S.
Deposit date:	2022-06-20
Release date:	2022-11-02
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.214 Å)
Cite:	Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg.Med.Chem., 74, 2022

Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor:	1-{2-[(2S)-2-{[(3-chloro-2-fluorophenyl)methyl]carbamoyl}pyrrolidin-1-yl]-2-oxoethyl}-1H-indazole-3-carboxamide, Complement factor D
Authors:	Raman, K, Babu, Y.S.
Deposit date:	2022-06-23
Release date:	2022-11-02
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.986 Å)
Cite:	Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg.Med.Chem., 74, 2022

Scaffold Hopping via Ring Opening Enables Identification of Acyclic Compounds as New Complement Factor D Inhibitors
Descriptor:	Complement factor D, N-(6-bromopyridin-2-yl)-1-[(3-cyanophenyl)acetyl]-L-prolinamide
Authors:	Raman, K, Babu, Y.S.
Deposit date:	2022-06-09
Release date:	2022-11-02
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.166 Å)
Cite:	Scaffold hopping via ring opening enables identification of acyclic compounds as new complement Factor D inhibitors. Bioorg.Med.Chem., 74, 2022