3NDA
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![BU of 3nda by Molmil](/molmil-images/mine/3nda) | Crystal structure of serpin from tick Ixodes ricinus | Descriptor: | PENTAETHYLENE GLYCOL, Serpin-2 | Authors: | Rezacova, P, Kovarova, Z, Chmelar, J, Mares, M. | Deposit date: | 2010-06-07 | Release date: | 2010-10-27 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A tick salivary protein targets cathepsin G and chymase and inhibits host inflammation and platelet aggregation. Blood, 117, 2011
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7PMU
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![BU of 7pmu by Molmil](/molmil-images/mine/7pmu) | Crystal structure of native Iripin-8 | Descriptor: | DI(HYDROXYETHYL)ETHER, HEXAETHYLENE GLYCOL, Serpin-8, ... | Authors: | Polderdijk, S, Kotal, J, Chmelar, J, Huntington, J.A. | Deposit date: | 2021-09-02 | Release date: | 2021-10-13 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Ixodes ricinus Salivary Serpin Iripin-8 Inhibits the Intrinsic Pathway of Coagulation and Complement. Int J Mol Sci, 22, 2021
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7QTZ
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![BU of 7qtz by Molmil](/molmil-images/mine/7qtz) | Crystal structure of Iripin-1 serpin from tick Ixodes ricinus | Descriptor: | MAGNESIUM ION, Putative salivary serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules. Front Immunol, 14, 2023
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7ZBF
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![BU of 7zbf by Molmil](/molmil-images/mine/7zbf) | Crystal structure of native Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | Iripin-4 serpin, NICKEL (II) ION | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-23 | Release date: | 2023-04-05 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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7ZAS
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![BU of 7zas by Molmil](/molmil-images/mine/7zas) | Crystal structure of cleaved Iripin-4 serpin from tick Ixodes ricinus | Descriptor: | CHLORIDE ION, Iripin-4 serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-03-22 | Release date: | 2023-03-29 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Conformational transition of the Ixodes ricinus salivary serpin Iripin-4. Acta Crystallogr D Struct Biol, 79, 2023
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5O46
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![BU of 5o46 by Molmil](/molmil-images/mine/5o46) | Crystal structure of Iristatin, a secreted salivary cystatin from the hard tick Ixodes ricinus | Descriptor: | GLYCEROL, Iristatin | Authors: | Busa, M, Rezacova, P, Kotal, J, Kotsyfakis, M, Mares, M. | Deposit date: | 2017-05-26 | Release date: | 2018-06-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | The structure and function of Iristatin, a novel immunosuppressive tick salivary cystatin. Cell.Mol.Life Sci., 76, 2019
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7PK4
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![BU of 7pk4 by Molmil](/molmil-images/mine/7pk4) | Tick salivary cystatin Ricistatin in complex with cathepsin V | Descriptor: | 1,2-ETHANEDIOL, Cathepsin L2, DI(HYDROXYETHYL)ETHER, ... | Authors: | Busa, M, Mares, M. | Deposit date: | 2021-08-25 | Release date: | 2022-12-14 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Protease-bound structure of Ricistatin provides insights into the mechanism of action of tick salivary cystatins in the vertebrate host. Cell.Mol.Life Sci., 80, 2023
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6ZTK
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![BU of 6ztk by Molmil](/molmil-images/mine/6ztk) | Crystal structure of Mialostatin, a gut cystatin from the hard tick Ixodes ricinus | Descriptor: | FRAGMENT OF TRITON X-100, Mialostatin, SULFATE ION | Authors: | Busa, M, Rezacova, P, Mares, M. | Deposit date: | 2020-07-20 | Release date: | 2021-06-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Mialostatin, a Novel Midgut Cystatin from Ixodes ricinus Ticks: Crystal Structure and Regulation of Host Blood Digestion. Int J Mol Sci, 22, 2021
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7AHP
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![BU of 7ahp by Molmil](/molmil-images/mine/7ahp) | Crystal structure of Ixodes ricinus serpin - Iripin-3 | Descriptor: | Putative salivary serpin, TRIS-HYDROXYMETHYL-METHYL-AMMONIUM | Authors: | Kascakova, B, Kuta Smatanova, I, Prudnikova, T. | Deposit date: | 2020-09-25 | Release date: | 2021-03-10 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Iripin-3, a New Salivary Protein Isolated From Ixodes ricinus Ticks, Displays Immunomodulatory and Anti-Hemostatic Properties In Vitro Front Immunol, 12, 2021
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7B2T
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![BU of 7b2t by Molmil](/molmil-images/mine/7b2t) | |