9IIV
 
 | | human alpha 7 nicotinic acetylcholine receptor in complex with GAT107 and calcium (open state) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Liu, S, Zheng, Y, Tian, C. | | Deposit date: | 2024-06-21 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.89 Å) | | Cite: | Structural basis for allosteric agonism of human alpha 7 nicotinic acetylcholine receptors.
Cell Discov, 11, 2025
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9IIR
 | | human alpha 7 nicotinic acetylcholine receptor in complex with GAT107 and calcium (desensitized state) | | Descriptor: | (3aR,4S,9bS)-4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Liu, S, Zheng, Y, Tian, C. | | Deposit date: | 2024-06-21 | | Release date: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Structural basis for allosteric agonism of human alpha 7 nicotinic acetylcholine receptors.
Cell Discov, 11, 2025
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6MSK
 | | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | | Authors: | Mao, Y.D. | | Deposit date: | 2018-10-16 | | Release date: | 2018-11-21 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565, 2019
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9GXA
 | | CENP-A/H4 di-tetrasome assembled on alpha-satellite DNA. | | Descriptor: | 147 bp alpha-satellite DNA, 147 bp human alpha-satellite DNA, Histone H3-like centromeric protein A, ... | | Authors: | Ali-Ahmad, A, Sekulic, N. | | Deposit date: | 2024-09-29 | | Release date: | 2025-01-29 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (4.01 Å) | | Cite: | Non-nucleosomal (CENP-A/H4) 2 - DNA complexes as a possible platform for centromere organization.
Biorxiv, 2025
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9IMJ
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8YQY
 | | ASFV RNA polymerase-M1249L complex complete | | Descriptor: | C122R, C147L, D339L, ... | | Authors: | Feng, X.Y. | | Deposit date: | 2024-03-20 | | Release date: | 2024-11-06 | | Last modified: | 2025-06-11 | | Method: | ELECTRON MICROSCOPY (3.68 Å) | | Cite: | Transcription regulation of African swine fever virus: dual role of M1249L.
Nat Commun, 15, 2024
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8YQU
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8YQT
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8YQZ
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8YQX
 | | ASFV RNA polymerase-M1249L complex4 | | Descriptor: | D339L, DNA-directed RNA polymerase subunit, M1249L | | Authors: | Feng, X.Y. | | Deposit date: | 2024-03-20 | | Release date: | 2024-11-06 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.97 Å) | | Cite: | Transcription regulation of African swine fever virus: dual role of M1249L.
Nat Commun, 15, 2024
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9HCH
 | | Mouse mitoribosome large subunit assembly intermediate bound to NSUN4, METRF4, GTPBP7 and the MALSU1-L0R8F8-mt-ACP complex, State C1 (SAMC knock-out) | | Descriptor: | 16S rRNA (1584-MER), 5-cytosine rRNA methyltransferase NSUN4, Acyl carrier protein, ... | | Authors: | Singh, V, Rorbach, J, Freyer, C, Amunts, A, Wredenberg, A. | | Deposit date: | 2024-11-10 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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9HCE
 | | Mouse mitoribosome large subunit assembly intermediate (without uL16m) bound to MRM3 dimer and the MALSU-L0R8F8-mt-ACP complex, State A3 (SAMC knock out) | | Descriptor: | 16S rRNA (1584-MER), Acyl carrier protein, mitochondrial, ... | | Authors: | Singh, V, Rorbach, J, Freyer, C, Amunts, A, Wredenberg, A. | | Deposit date: | 2024-11-08 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (7.31 Å) | | Cite: | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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9HCC
 | | Mouse mitoribosome large subunit assembly intermediate (without uL16m) bound to MRM3-dimer, DDX28 and the MALSU-L0R8F8-mt-ACP complex, State A1 (SAMC knock-out) | | Descriptor: | 16S rRNA (1584-MER), Acyl carrier protein, mitochondrial, ... | | Authors: | Singh, V, Rorbach, J, Freyer, C, Amunts, A, Wredenberg, A. | | Deposit date: | 2024-11-08 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (5.67 Å) | | Cite: | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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9HCD
 | | Mouse mitoribosome large subunit assembly intermediate (with uL16m) bound to MRM3-dimer, DDX28 and the MALSU-L0R8F8-mt-ACP complex, state A2 (SAMC knock-out) | | Descriptor: | 16S rRNA (1584-MER), Acyl carrier protein, mitochondrial, ... | | Authors: | Singh, V, Rorbach, J, Freyer, C, Amunts, A, Wredenberg, A. | | Deposit date: | 2024-11-08 | | Release date: | 2025-06-11 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (4.63 Å) | | Cite: | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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9HCG
 | | Mouse mitoribosome large subunit assembly intermediate bound to NSUN4, METRF4, MRM2, GTPBP7 and MALSU1-L0R8F8-mt-ACP complex, State D (SAMC knock-out) | | Descriptor: | 16S rRNA (1584-MER), 5-cytosine rRNA methyltransferase NSUN4, Acyl carrier protein, ... | | Authors: | Singh, V, Freyer, C, Amunts, A, Wredenberg, A. | | Deposit date: | 2024-11-08 | | Release date: | 2025-06-18 | | Last modified: | 2025-07-09 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | The mitochondrial methylation potential gates mitoribosome assembly.
Nat Commun, 16, 2025
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5ISM
 | | Human DPP4 in complex with a novel 5,5,6-tricyclic pyrrolidine inhibitor | | Descriptor: | (2R,3S,5R)-2-(2,5-difluorophenyl)-5-(7H-pyrrolo[3',4':3,4]pyrazolo[1,5-a]pyrimidin-8(9H)-yl)oxan-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Scapin, G. | | Deposit date: | 2016-03-15 | | Release date: | 2016-05-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
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5IL7
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6N6B
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6MSD
 | | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | | Authors: | Mao, Y.D. | | Deposit date: | 2018-10-16 | | Release date: | 2018-12-05 | | Last modified: | 2025-05-21 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565, 2019
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8YQW
 | | ASFV RNA polymerase-M1249L complex3 | | Descriptor: | C122R, C147L, D339L, ... | | Authors: | Feng, X.Y. | | Deposit date: | 2024-03-20 | | Release date: | 2024-11-06 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.68 Å) | | Cite: | Transcription regulation of African swine fever virus: dual role of M1249L.
Nat Commun, 15, 2024
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6MSE
 | | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | | Authors: | Mao, Y.D. | | Deposit date: | 2018-10-16 | | Release date: | 2018-11-21 | | Last modified: | 2024-11-20 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565, 2019
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6MSH
 | | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome | | Descriptor: | 26S proteasome complex subunit SEM1, 26S proteasome non-ATPase regulatory subunit 1, 26S proteasome non-ATPase regulatory subunit 11, ... | | Authors: | Mao, Y.D. | | Deposit date: | 2018-10-16 | | Release date: | 2018-11-21 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Cryo-EM structures and dynamics of substrate-engaged human 26S proteasome.
Nature, 565, 2019
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8ZLI
 | | BTA-2-bound E46K alpha-synuclein fibrils | | Descriptor: | Alpha-synuclein, ~{N},~{N}-dimethyl-4-(6-methyl-1,3-benzothiazol-2-yl)aniline | | Authors: | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | Deposit date: | 2024-05-20 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8ZLO
 | | F0502B-bound E46K alpha-synuclein fibril | | Descriptor: | 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol, Alpha-synuclein | | Authors: | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | Deposit date: | 2024-05-20 | | Release date: | 2024-09-11 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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8ZMY
 | | F0502B-bound WT polymorph 5a alpha-synuclein fibril | | Descriptor: | 2-bromanyl-4-[(~{E})-2-[6-[2-(2-fluoranylethoxy)ethyl-methyl-amino]-5-methyl-1,3-benzothiazol-2-yl]ethenyl]phenol, Alpha-synuclein | | Authors: | Liu, K.E, Tao, Y.Q, Li, D, Liu, C. | | Deposit date: | 2024-05-24 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Binding adaptability of chemical ligands to polymorphic alpha-synuclein amyloid fibrils.
Proc.Natl.Acad.Sci.USA, 121, 2024
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