7F4O
 
 | | Crystal structure of MTA1-p2 complex | | Descriptor: | MT-a70 family protein, Transmembrane protein, putative | | Authors: | Chen, J, Liu, L. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-15 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation
Nat Commun, 13, 2022
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7F4Q
 | | Crystal structure of SAH-bound MTA1-p2 complex | | Descriptor: | MT-a70 family protein, S-ADENOSYL-L-HOMOCYSTEINE, Transmembrane protein, ... | | Authors: | Chen, J, Liu, L. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.42 Å) | | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation
Nat Commun, 13, 2022
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7F4L
 | | Crystal structure of MTA1-p1-p2 complex | | Descriptor: | MT-a70 family protein, Transmembrane protein, putative, ... | | Authors: | Chen, J, Liu, L. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-15 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.72 Å) | | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation
Nat Commun, 13, 2022
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7F4M
 | | Crystal structure of SAM-bound MTA1-p1-p2 complex | | Descriptor: | MT-a70 family protein, S-ADENOSYLMETHIONINE, Transmembrane protein, ... | | Authors: | Chen, J, Liu, L. | | Deposit date: | 2021-06-21 | | Release date: | 2022-06-15 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.58 Å) | | Cite: | Structural basis for MTA1c-mediated DNA N6-adenine methylation
Nat Commun, 13, 2022
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7F4T
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7OIL
 | | mPI3Kd in complex with compound 58 | | Descriptor: | 2-[(1S)-1-cyclopropylethyl]-5-[4-methyl-2-[[6-(2-oxidanylidenepyrrolidin-1-yl)pyridin-2-yl]amino]-1,3-thiazol-5-yl]-7-methylsulfonyl-3H-isoindol-1-one, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION | | Authors: | Petersen, J. | | Deposit date: | 2021-05-11 | | Release date: | 2021-07-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
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7OI4
 | | mPI3Kd in complex with compound 12 | | Descriptor: | N-[5-[2-[(1S)-1-cyclopropylethyl]-7-[[4-[(dimethylamino)methyl]phenyl]sulfamoyl]-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | | Authors: | Petersen, J. | | Deposit date: | 2021-05-11 | | Release date: | 2021-07-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
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7OIS
 | | mPI3Kd in complex with compound 7 | | Descriptor: | N-[5-[2-[(1S)-1-cyclopropylethyl]-7-[(3-methylsulfonylphenyl)sulfamoyl]-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]ethanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION | | Authors: | Petersen, J. | | Deposit date: | 2021-05-12 | | Release date: | 2021-07-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
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7OIJ
 | | mPI3Kd in complex with an inhibitor | | Descriptor: | 6-[[5-[2-[(1S)-1-cyclopropylethyl]-7-(methylsulfamoyl)-1-oxidanylidene-3H-isoindol-5-yl]-4-methyl-1,3-thiazol-2-yl]amino]-N-[3-(dimethylamino)propyl]pyridine-2-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, SODIUM ION, ... | | Authors: | Petersen, J. | | Deposit date: | 2021-05-11 | | Release date: | 2021-07-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Discovery of AZD8154, a Dual PI3K gamma delta Inhibitor for the Treatment of Asthma.
J.Med.Chem., 64, 2021
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8R7F
 | | Transcription factor BARHL2 homodimer with spacing two bp | | Descriptor: | BarH-like 2 homeobox protein, DNA (5'-D(*CP*TP*AP*AP*AP*CP*GP*GP*GP*CP*AP*AP*TP*TP*AP*G)-3'), DNA (5'-D(*CP*TP*AP*AP*TP*TP*GP*CP*CP*CP*GP*TP*TP*TP*AP*G)-3') | | Authors: | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | | Deposit date: | 2023-11-24 | | Release date: | 2024-12-04 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | DNA-guided transcription factor interactions extend human gene regulatory code.
Nature, 641, 2025
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8R7Z
 | | transcription factor BARHL2 homodimer with spacing four bp | | Descriptor: | BarH-like 2 homeobox protein, DNA (5'-D(P*AP*CP*CP*GP*TP*TP*TP*AP*G)-3'), DNA (5'-D(P*CP*TP*AP*AP*AP*CP*GP*GP*T)-3'), ... | | Authors: | Morgunova, E, Popov, A, Yin, Y, Taipale, J. | | Deposit date: | 2023-11-27 | | Release date: | 2024-12-04 | | Last modified: | 2025-06-11 | | Method: | X-RAY DIFFRACTION (3.26 Å) | | Cite: | DNA-guided transcription factor interactions extend human gene regulatory code.
Nature, 641, 2025
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2LWF
 | | Structure of N-terminal domain of a plant Grx | | Descriptor: | Monothiol glutaredoxin-S16, chloroplastic | | Authors: | Feng, Y. | | Deposit date: | 2012-07-28 | | Release date: | 2013-05-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural insights into the N-terminal GIY-YIG endonuclease activity of Arabidopsis glutaredoxin AtGRXS16 in chloroplasts.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7YTJ
 | | Cryo-EM structure of VTC complex | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, INOSITOL HEXAKISPHOSPHATE, PHOSPHATE ION, ... | | Authors: | Guan, Z.Y, Chen, J, Liu, R.W, Chen, Y.K, Xing, Q, Du, Z.M, Liu, Z. | | Deposit date: | 2022-08-15 | | Release date: | 2023-02-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex.
Nat Commun, 14, 2023
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3WX6
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9NCC
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9NAT
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6LBI
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6LNL
 | | ASFV core shell protein p15 | | Descriptor: | 60 kDa polyprotein | | Authors: | Guo, F, Shi, Y, Peng, G. | | Deposit date: | 2019-12-30 | | Release date: | 2020-12-30 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.9286 Å) | | Cite: | The structural basis of African swine fever virus core shell protein p15 binding to DNA.
Faseb J., 35, 2021
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6GG5
 | | Crystal structure of M2 PYK in complex with Tryptophan. | | Descriptor: | PHOSPHATE ION, POTASSIUM ION, Pyruvate kinase PKM, ... | | Authors: | McNae, I.W, Yuan, M, Walkinshaw, M.D. | | Deposit date: | 2018-05-02 | | Release date: | 2018-05-23 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
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6GG6
 | | Crystal structure of M2 PYK in complex with Serine. | | Descriptor: | MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | McNae, I.W, Yuan, M, Walkinshaw, M.D. | | Deposit date: | 2018-05-02 | | Release date: | 2018-05-23 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.96 Å) | | Cite: | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
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6GG3
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6GG4
 | | Crystal structure of M2 PYK in complex with Phenyalanine. | | Descriptor: | PHENYLALANINE, PHOSPHATE ION, POTASSIUM ION, ... | | Authors: | McNae, I.W, Yuan, M, Walkinshaw, M.D. | | Deposit date: | 2018-05-02 | | Release date: | 2018-05-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | An allostatic mechanism for M2 pyruvate kinase as an amino-acid sensor.
Biochem. J., 475, 2018
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6GMM
 | | Crystal structure of Helicobacter pylori adhesin LabA | | Descriptor: | adhesin LabA | | Authors: | Paraskevopoulou, V, Overman, R.C, Stolnik, S, Winkler, S, Gellert, P, Falcone, F.H, Schimpl, M. | | Deposit date: | 2018-05-27 | | Release date: | 2019-12-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Structural and binding characterization of the LacdiNAc-specific adhesin (LabA; HopD) exodomain from Helicobacter pylori
Current Research in Structural Biology, 2021
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6LBM
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8G9X
 | | Cryo-EM structure of vFP49.02 Fab in complex with HIV-1 Env BG505 DS-SOSIP.664 (conformation 2) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | | Authors: | Changela, A, Gorman, J, Kwong, P.D. | | Deposit date: | 2023-02-22 | | Release date: | 2023-04-19 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.46 Å) | | Cite: | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization.
J.Virol., 97, 2023
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