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Corynebacterium 2,5-DKGR A and Phe 22 replaced with Tyr (F22Y), Lys 232 replaced with Gly (K232G), Arg 238 replaced with His (R238H)and Ala 272 replaced with Gly (A272G)in presence of NADH cofactor
Descriptor:	2,5-diketo-D-gluconic acid reductase A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, SULFATE ION
Authors:	Sanli, G, Blaber, M.
Deposit date:	2002-07-29
Release date:	2003-08-12
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural alteration of cofactor specificity in Corynebacterium 2,5-diketo-D-gluconic acid reductase Protein Sci., 13, 2004

1P63

Human Acidic Fibroblast Growth Factor. 140 Amino Acid Form with Amino Terminal His Tag and Leu111 Replaced with Ile (L111I)
Descriptor:	ACIDIC FIBROBLAST GROWTH FACTOR, FORMIC ACID, SULFATE ION
Authors:	Brych, S.R, Kim, J, Logan, T.M, Blaber, M.
Deposit date:	2003-04-28
Release date:	2004-05-11
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Accommodation of a highly symmetric core within a symmetric protein superfold Protein Sci., 12, 2003

1Q04

Crystal structure of FGF-1, S50E/V51N
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1
Authors:	Kim, J, Blaber, M.
Deposit date:	2003-07-15
Release date:	2004-07-27
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor Protein Sci., 14, 2005

1Q03

Crystal structure of FGF-1, S50G/V51G mutant
Descriptor:	Heparin-binding growth factor 1
Authors:	Kim, J, Blaber, M.
Deposit date:	2003-07-15
Release date:	2004-07-27
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Sequence swapping does not result in conformation swapping for the beta4/beta5 and beta8/beta9 beta-hairpin turns in human acidic fibroblast growth factor Protein Sci., 14, 2005

1NZK

Crystal Structure of a Multiple Mutant (L44F, L73V, V109L, L111I, C117V) of Human Acidic Fibroblast Growth Factor
Descriptor:	Acidic Fibroblast Growth Factor, FORMIC ACID, SULFATE ION
Authors:	Brych, S.R, Kim, J, Logan, T.M, Blaber, M.
Deposit date:	2003-02-18
Release date:	2004-03-02
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Accommodation of a highly symmetric core within a symmetric protein superfold. Protein Sci., 12, 2003

1RG8

Human Acidic Fibroblast Growth Factor (haFGF-1) at 1.10 angstrom resolution (140 amino acid form)
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1
Authors:	Bernett, M.J, Somasundaram, T, Blaber, M.
Deposit date:	2003-11-11
Release date:	2004-10-05
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.1 Å)
Cite:	An atomic resolution structure for human fibroblast growth factor 1. Proteins, 57, 2004

3O4B

Crystal structure of Symfoil-4T: de novo designed beta-trefoil architecture with symmetric primary structure
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ...
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-07-26
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3O4A

Crystal structure of Symfoil-2: de novo designed beta-trefoil architecture with symmetric primary structure
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, de novo designed beta-trefoil architecture with symmetric primary structure
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-07-26
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3O4D

Crystal structure of Symfoil-4P: de novo designed beta-trefoil architecture with symmetric primary structure
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ...
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-07-26
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3OL0

Crystal structure of Monofoil-4P homo-trimer: de novo designed monomer trefoil-fold sub-domain which forms homo-trimer assembly
Descriptor:	SULFATE ION, de novo designed monomer trefoil-fold sub-domain which forms homo-trimer assembly
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-08-25
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.483 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3O49

Crystal structure of Symfoil-1: de novo designed beta-trefoil architecture with symmetric primary structure
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, de novo designed beta-trefoil architecture with symmetric primary structure
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-07-26
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3O4C

Crystal structure of Symfoil-4V: de novo designed beta-trefoil architecture with symmetric primary structure
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, SULFATE ION, ...
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-07-26
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

3OGF

Crystal structure of Difoil-4P homo-trimer: de novo designed dimeric trefoil-fold sub-domain which forms homo-trimer assembly
Descriptor:	SULFATE ION, de novo designed dimeric trefoil-fold sub-domain which forms homo-trimer assembly
Authors:	Lee, J, Blaber, M.
Deposit date:	2010-08-16
Release date:	2010-12-22
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.864 Å)
Cite:	Experimental support for the evolution of symmetric protein architecture from a simple peptide motif. Proc.Natl.Acad.Sci.USA, 108, 2011

4QKR

Crystal Structure of 6xTyr/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22Y/L44Y/L64Y/L85Y/L108Y/L132Y, Primitive Version 2)
Descriptor:	DE NOVO PROTEIN 6XTYR/PV2, IMIDAZOLE
Authors:	Longo, L.M, Blaber, M, Tenorio, C.A.
Deposit date:	2014-06-09
Release date:	2015-01-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.746 Å)
Cite:	A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding. Protein Sci., 24, 2015

4QKS

Crystal Structure of 6xTrp/PV2: de novo designed beta-trefoil architecture with symmetric primary structure (L22W/L44W/L64W/L85W/L108W/L132W his Primitive Version 2)
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DE NOVO PROTEIN 6XTRP/PV2, SULFATE ION
Authors:	Longo, L.M, Tenorio, C.A, Blaber, M.
Deposit date:	2014-06-09
Release date:	2015-01-14
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	A single aromatic core mutation converts a designed "primitive" protein from halophile to mesophile folding. Protein Sci., 24, 2015

4Q91

Crystal structure of C16A/K12V/C117V/P134V mutant of human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Fibroblast growth factor 1, PHOSPHATE ION
Authors:	Xia, X, Blaber, M.
Deposit date:	2014-04-28
Release date:	2015-03-11
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.799 Å)
Cite:	Mutation choice to eliminate buried free cysteines in protein therapeutics. J.Pharm.Sci., 104, 2015

1HW6

CRYSTAL STRUCTURE OF APO-2,5-DIKETO-D-GLUCONATE REDUCTASE
Descriptor:	2,5-DIKETO-D-GLUCONIC ACID REDUCTASE, CHLORIDE ION, MAGNESIUM ION
Authors:	Sanli, G, Blaber, M.
Deposit date:	2001-01-09
Release date:	2001-06-20
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural assembly of the active site in an aldo-keto reductase by NADPH cofactor. J.Mol.Biol., 309, 2001

1JY0

Human acidic fibroblast growth factor. 141 amino acid form with amino terminal His tag and Cys 117 replaced with Val (C117V).
Descriptor:	FORMIC ACID, acidic fibroblast growth factor
Authors:	Brych, S.R, Blaber, M.
Deposit date:	2001-09-10
Release date:	2003-08-12
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Accommodation of a highly symmetric core within a symmetric protein superfold. Protein Sci., 12, 2003

3BAG

Crystal structure of K112N/N114A mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-07
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BAU

Crystal structure of K12V/L26D/D28A mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-08
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BAQ

Crystal structure of L26A mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-08
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BAH

Crystal structure of K112N mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-07
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BAO

Crystal structure of L26N mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-08
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BAV

Crystal structure of L26A/D28N mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-08
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.62 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

3BB2

Crystal structure of L26D/D28N mutant of Human acidic fibroblast growth factor
Descriptor:	FORMIC ACID, Heparin-binding growth factor 1, SULFATE ION
Authors:	Lee, J, Blaber, M.
Deposit date:	2007-11-09
Release date:	2008-04-15
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	A logical OR redundancy within the Asx-Pro-Asx-Gly type I beta-turn motif. J.Mol.Biol., 377, 2008

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