8CGC
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![BU of 8cgc by Molmil](/molmil-images/mine/8cgc) | Structure of CSF1R in complex with a pyrollopyrimidine (compound 23) | Descriptor: | (2S)-2-hydroxybutanedioic acid, GLYCEROL, Macrophage colony-stimulating factor 1 receptor, ... | Authors: | Aarhus, T.I, Bjornstad, F, Wolowczyk, C, Larsen, K.U, Rognstad, L, Leithaug, T, Unger, A, Habenberger, P, Wolff, A, Bjorkoy, G, Pridans, C, Eickhoff, J, Klebl, B, Hoff, B.H, Sundby, E. | Deposit date: | 2023-02-03 | Release date: | 2023-05-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.925 Å) | Cite: | Synthesis and Development of Highly Selective Pyrrolo[2,3- d ]pyrimidine CSF1R Inhibitors Targeting the Autoinhibited Form. J.Med.Chem., 66, 2023
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8C5Z
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![BU of 8c5z by Molmil](/molmil-images/mine/8c5z) | RPA tetrameric supercomplex with AROD-OB-1 | Descriptor: | RPA14 subunit of the hetero-oligomeric complex involved in homologous recombination, RPA32 subunit of the hetero-oligomeric complex involved in homologous recombination, Replication factor A, ... | Authors: | Madru, C, Martinez-Carranza, M, Legrand, P, Sauguet, L. | Deposit date: | 2023-01-10 | Release date: | 2023-05-10 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | DNA-binding mechanism and evolution of replication protein A. Nat Commun, 14, 2023
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6R7X
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![BU of 6r7x by Molmil](/molmil-images/mine/6r7x) | CryoEM structure of calcium-bound human TMEM16K / Anoctamin 10 in detergent (2mM Ca2+, closed form) | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Anoctamin-10, CALCIUM ION, ... | Authors: | Pike, A.C.W, Bushell, S.R, Shintre, C.A, Tessitore, A, Baronina, A, Chu, A, Mukhopadhyay, S, Shrestha, L, Chalk, R, Burgess-Brown, N.A, Love, J, Huiskonen, J.T, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC) | Deposit date: | 2019-03-29 | Release date: | 2019-05-01 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nat Commun, 10, 2019
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6LR0
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![BU of 6lr0 by Molmil](/molmil-images/mine/6lr0) | structure of human bile salt exporter ABCB11 | Descriptor: | Bile salt export pump | Authors: | Wang, L, Hou, W.T, Chen, L, Jiang, Y.L, Xu, D, Sun, L.F, Zhou, C.Z, Chen, Y. | Deposit date: | 2020-01-15 | Release date: | 2020-04-15 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Cryo-EM structure of human bile salts exporter ABCB11. Cell Res., 30, 2020
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6R8Q
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![BU of 6r8q by Molmil](/molmil-images/mine/6r8q) | STRUCTURE OF THE WNT DEACYLASE NOTUM IN COMPLEX WITH A BENZOTRIAZOLE FRAGMENT | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ... | Authors: | Ruza, R.R, Vecchia, L, Jones, E.Y. | Deposit date: | 2019-04-02 | Release date: | 2019-05-08 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Discovery of 2-phenoxyacetamides as inhibitors of the Wnt-depalmitoleating enzyme NOTUM from an X-ray fragment screen. Medchemcomm, 10, 2019
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7ZE1
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![BU of 7ze1 by Molmil](/molmil-images/mine/7ze1) | Tribolium castaneum hexamerin 2 | Descriptor: | Larval serum protein 1 gamma chain-like Protein | Authors: | Valentova, L, Fuzik, T, Plevka, P. | Deposit date: | 2022-03-30 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Polyelectrolyte coating of cryo-EM grids improves lateral distribution and prevents aggregation of macromolecules. Acta Crystallogr D Struct Biol, 78, 2022
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8CAR
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![BU of 8car by Molmil](/molmil-images/mine/8car) | Discovery of the lanthipeptide Curvocidin and structural insights into its trifunctional synthetase CuvL | Descriptor: | NITRATE ION, PHOSPHATE ION, Serine/threonine protein kinase | Authors: | Martins, B.M, Sigurdsson, A, Duettmann, A.A, Jasyk, M, Dimos-Roehl, B, Schoepf, F, Gemander, M, Knittel, C.H, Schegotzki, R, Schmid, B, Kosol, S, Pommerening, L, Gonzalez-Viegas, M, Seidel, M, Huegelland, M, Leimkuehler, S, Dobbek, H, Mainz, A, Suessmuth, R. | Deposit date: | 2023-01-24 | Release date: | 2023-06-14 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.68 Å) | Cite: | Discovery of the Lanthipeptide Curvocidin and Structural Insights into its Trifunctional Synthetase CuvL. Angew.Chem.Int.Ed.Engl., 62, 2023
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6R4R
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![BU of 6r4r by Molmil](/molmil-images/mine/6r4r) | Cryo-EM Structure of the PI3-Kinase SH3 Domain Amyloid Fibril | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha | Authors: | Roeder, C, Vettore, N, Mangels, L.N, Gremer, L, Ravelli, R.B.G, Willbold, D, Hoyer, W, Buell, A.K, Schroder, G.F. | Deposit date: | 2019-03-23 | Release date: | 2019-08-28 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Atomic structure of PI3-kinase SH3 amyloid fibrils by cryo-electron microscopy. Nat Commun, 10, 2019
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6R4T
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![BU of 6r4t by Molmil](/molmil-images/mine/6r4t) | |
8CLJ
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![BU of 8clj by Molmil](/molmil-images/mine/8clj) | TFIIIC TauB-DNA dimer | Descriptor: | General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, General transcription factor 3C polypeptide 4, ... | Authors: | Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. | Deposit date: | 2023-02-16 | Release date: | 2023-06-21 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
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7ZC0
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![BU of 7zc0 by Molmil](/molmil-images/mine/7zc0) | 4,6-alpha-glucanotransferase GtfC from Geobacillus 12AMOR1 | Descriptor: | 4,6-alpha-Glucanotransferase, CALCIUM ION, GLYCEROL | Authors: | Pijning, T, Dijkhuizen, L, Guskov, A, te Poele, E.M. | Deposit date: | 2022-03-25 | Release date: | 2022-12-07 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Crystal Structure of 4,6-alpha-Glucanotransferase GtfC-Delta C from Thermophilic Geobacillus 12AMOR1: Starch Transglycosylation in Non-Permuted GH70 Enzymes. J.Agric.Food Chem., 70, 2022
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8CLL
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![BU of 8cll by Molmil](/molmil-images/mine/8cll) | Structural insights into human TFIIIC promoter recognition | Descriptor: | General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, General transcription factor 3C polypeptide 4, ... | Authors: | Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. | Deposit date: | 2023-02-16 | Release date: | 2023-06-21 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
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6R5E
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![BU of 6r5e by Molmil](/molmil-images/mine/6r5e) | |
6R62
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![BU of 6r62 by Molmil](/molmil-images/mine/6r62) | Crystal structure of a class II pyruvate aldolase from Sphingomonas wittichii RW1 in complex with hydroxypyruvate | Descriptor: | 3-HYDROXYPYRUVIC ACID, ACETATE ION, BROMIDE ION, ... | Authors: | Marsden, S.R, Mestrom, L, Hagedoorn, P.L, Bento, I, McMillan, D.G.G, Hanefeld, U. | Deposit date: | 2019-03-26 | Release date: | 2019-05-29 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | CH-Pi Interactions Promote the Conversion of Hydroxypyruvate in a Class II Pyruvate Aldolase Adv.Synth.Catal., 2019
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8CP5
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![BU of 8cp5 by Molmil](/molmil-images/mine/8cp5) | |
8CLI
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![BU of 8cli by Molmil](/molmil-images/mine/8cli) | TFIIIC TauB-DNA monomer | Descriptor: | DNA (35-MER), General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 2, ... | Authors: | Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. | Deposit date: | 2023-02-16 | Release date: | 2023-06-21 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
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8CP2
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![BU of 8cp2 by Molmil](/molmil-images/mine/8cp2) | |
6R7L
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![BU of 6r7l by Molmil](/molmil-images/mine/6r7l) | Ribosome-bound SecYEG translocon in a nanodisc | Descriptor: | Protein translocase subunit SecY, SecE,Protein translocase subunit SecE,Protein translocase subunit SecE,Protein translocase subunit SecE, SecG | Authors: | Kater, L, Beckmann, R, Kedrov, A. | Deposit date: | 2019-03-29 | Release date: | 2019-08-07 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | Partially inserted nascent chain unzips the lateral gate of the Sec translocon. Embo Rep., 20, 2019
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8CLK
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![BU of 8clk by Molmil](/molmil-images/mine/8clk) | TFIIIC TauA complex | Descriptor: | General transcription factor 3C polypeptide 1, General transcription factor 3C polypeptide 3, General transcription factor 3C polypeptide 5, ... | Authors: | Seifert-Davila, W, Girbig, M, Hauptmann, L, Hoffmann, T, Eustermann, S, Mueller, C.W. | Deposit date: | 2023-02-16 | Release date: | 2023-06-21 | Last modified: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structural insights into human TFIIIC promoter recognition. Sci Adv, 9, 2023
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7Z1Y
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![BU of 7z1y by Molmil](/molmil-images/mine/7z1y) | PARP15 catalytic domain in complex with OUL245 | Descriptor: | DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15, [1,2,4]triazolo[3,4-b][1,3]benzothiazol-6-ol | Authors: | Maksimainen, M.M, Lehtio, L. | Deposit date: | 2022-02-25 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66, 2023
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6RAE
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![BU of 6rae by Molmil](/molmil-images/mine/6rae) | Structural analysis of the Salmonella type III secretion system ATPase InvC | Descriptor: | CHLORIDE ION, GLYCEROL, Secretory apparatus ATP synthase (Associated with virulence) | Authors: | Bernal, I, Roemermann, J, Flacht, L, Lunelli, M, Uetrecht, C, Kolbe, M. | Deposit date: | 2019-04-05 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Structural analysis of ligand-bound states of the Salmonella type III secretion system ATPase InvC. Protein Sci., 28, 2019
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7Z1V
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![BU of 7z1v by Molmil](/molmil-images/mine/7z1v) | PARP15 catalytic domain in complex with OUL208 | Descriptor: | 6-methoxy-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 | Authors: | Maksimainen, M.M, Lehtio, L. | Deposit date: | 2022-02-25 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66, 2023
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6RB4
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![BU of 6rb4 by Molmil](/molmil-images/mine/6rb4) | |
6RBM
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![BU of 6rbm by Molmil](/molmil-images/mine/6rbm) | TETR(D) E147A MUTANT IN COMPLEX WITH MINOCYCLINE AND MAGNESIUM | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, CHLORIDE ION, MAGNESIUM ION, ... | Authors: | Hinrichs, W, Palm, G.J, Berndt, L, Girbardt, B. | Deposit date: | 2019-04-11 | Release date: | 2019-08-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Thermodynamics, cooperativity and stability of the tetracycline repressor (TetR) upon tetracycline binding. Biochim Biophys Acta Proteins Proteom, 1868, 2020
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7Z2O
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![BU of 7z2o by Molmil](/molmil-images/mine/7z2o) | PARP15 catalytic domain in complex with OUL215 | Descriptor: | 8-methoxy-[1,2,4]triazolo[3,4-b][1,3]benzothiazole, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 | Authors: | Maksimainen, M.M, Lehtio, L. | Deposit date: | 2022-02-28 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | [1,2,4]Triazolo[3,4- b ]benzothiazole Scaffold as Versatile Nicotinamide Mimic Allowing Nanomolar Inhibition of Different PARP Enzymes. J.Med.Chem., 66, 2023
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