6D1S
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![BU of 6d1s by Molmil](/molmil-images/mine/6d1s) | Crystal structure of an apo chimeric human alpha1GABAA receptor | Descriptor: | chimeric alpha1GABAA receptor | Authors: | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | Deposit date: | 2018-04-12 | Release date: | 2018-08-22 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis of neurosteroid anesthetic action on GABAAreceptors. Nat Commun, 9, 2018
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3RQU
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![BU of 3rqu by Molmil](/molmil-images/mine/3rqu) | Crystal structure of a prokaryotic pentameric ligand-gated ion channel, ELIC | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ELIC Pentameric Ligand Gated Ion Channel from Erwinia Chrysanthemi, GLYCEROL | Authors: | Pan, J.J, Chen, Q, Yoshida, K, Cohen, A, Kong, X.P, Xu, Y, Tang, P. | Deposit date: | 2011-04-28 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.089 Å) | Cite: | Structure of the pentameric ligand-gated ion channel ELIC cocrystallized with its competitive antagonist acetylcholine. Nat Commun, 3, 2012
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2PJR
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![BU of 2pjr by Molmil](/molmil-images/mine/2pjr) | HELICASE PRODUCT COMPLEX | Descriptor: | DNA (5'-D(*AP*CP*TP*GP*C)-3'), DNA (5'-D(*GP*C)-3'), DNA (5'-D(*TP*TP*TP*TP*T)-3'), ... | Authors: | Velankar, S.S, Soultanas, P, Dillingham, M.S, Subramanya, H.S, Wigley, D.B. | Deposit date: | 1999-03-12 | Release date: | 1999-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal structures of complexes of PcrA DNA helicase with a DNA substrate indicate an inchworm mechanism. Cell(Cambridge,Mass.), 97, 1999
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4I5M
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![BU of 4i5m by Molmil](/molmil-images/mine/4i5m) | Selective & Brain-Permeable Polo-like Kinase-2 (Plk-2) Inhibitors that Reduce -Synuclein Phosphorylation in Rat Brain | Descriptor: | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, Serine/threonine-protein kinase PLK2 | Authors: | Aubele, D.L, Hom, R.K, Adler, M, Galemmo Jr, R.A, Bowers, S, Truong, A.P, Pan, H, Beroza, P, Neitz, R.J, Yao, N, Lin, M, Tonn, G, Zhang, H, Bova, M.P, Ren, Z, Tam, D, Ruslim, L, Baker, J, Diep, L, Fitzgerald, K, Hoffman, J, Motter, R, Fauss, D, Tanaka, P, Dappen, M, Jagodzinski, J, Chan, W, Konradi, A.W, Latimer, L, Zhu, Y.L, Artis, D.R, Sham, H.L, Anderson, J.P, Bergeron, M. | Deposit date: | 2012-11-28 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.801 Å) | Cite: | Selective and brain-permeable polo-like kinase-2 (Plk-2) inhibitors that reduce alpha-synuclein phosphorylation in rat brain. Chemmedchem, 8, 2013
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2XIM
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![BU of 2xim by Molmil](/molmil-images/mine/2xim) | ARGININE RESIDUES AS STABILIZING ELEMENTS IN PROTEINS | Descriptor: | D-XYLOSE ISOMERASE, MAGNESIUM ION, Xylitol | Authors: | Mrabet, N.T, Van Denbroek, A, Van Den Brande, I, Stanssens, P, Laroche, Y, Lambeir, A.-M, Matthyssens, G, Jenkins, J, Chiadmi, M, Vantilbeurgh, H, Rey, F, Janin, J, Quax, W.J, Lasters, I, Demaeyer, M, Wodak, S.J. | Deposit date: | 1991-05-29 | Release date: | 1993-04-15 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Arginine residues as stabilizing elements in proteins. Biochemistry, 31, 1992
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2KSR
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![BU of 2ksr by Molmil](/molmil-images/mine/2ksr) | |
2LKH
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![BU of 2lkh by Molmil](/molmil-images/mine/2lkh) | WSA minor conformation | Descriptor: | Acetylcholine receptor | Authors: | Xu, Y, Mowrey, D, Cui, T, Perez-Aguilar, J, Saven, J.G, Eckenhoff, R, Tang, P. | Deposit date: | 2011-10-11 | Release date: | 2012-01-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim.Biophys.Acta, 1818, 2011
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2LM2
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![BU of 2lm2 by Molmil](/molmil-images/mine/2lm2) | NMR structures of the transmembrane domains of the AChR b2 subunit | Descriptor: | Neuronal acetylcholine receptor subunit beta-2 | Authors: | Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P. | Deposit date: | 2011-11-18 | Release date: | 2012-03-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structures of the transmembrane domains of the a4b2 nAChR. Biochim.Biophys.Acta, 1818, 2012
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2LKG
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![BU of 2lkg by Molmil](/molmil-images/mine/2lkg) | WSA major conformation | Descriptor: | Acetylcholine receptor | Authors: | Xu, Y, Mowrey, D, Cui, T, Perez-Aguilar, J.M, Saven, J.G, Eckenhoff, R, Tang, P. | Deposit date: | 2011-10-11 | Release date: | 2012-01-11 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structure and dynamics of a designed water-soluble transmembrane domain of nicotinic acetylcholine receptor. Biochim.Biophys.Acta, 1818, 2011
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2JST
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![BU of 2jst by Molmil](/molmil-images/mine/2jst) | Four-Alpha-Helix Bundle with Designed Anesthetic Binding Pockets II: Halothane Effects on Structure and Dynamics | Descriptor: | 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE, Four-Alpha-Helix Bundle | Authors: | Cui, T, Bondarenko, V, Ma, D, Canlas, C, Brandon, N.R, Johansson, J.S, Tang, P, Xu, Y. | Deposit date: | 2007-07-12 | Release date: | 2008-05-27 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Four-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and dynamics Biophys.J., 94, 2008
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2LLY
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![BU of 2lly by Molmil](/molmil-images/mine/2lly) | NMR structures of the transmembrane domains of the nAChR a4 subunit | Descriptor: | Neuronal acetylcholine receptor subunit alpha-4 | Authors: | Bondarenko, V, Mowrey, D, Tillman, T, Cui, T, Liu, L.T, Xu, Y, Tang, P. | Deposit date: | 2011-11-18 | Release date: | 2012-03-28 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | NMR structures of the transmembrane domains of the a4b2 nAChR. Biochim.Biophys.Acta, 1818, 2012
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2K1E
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![BU of 2k1e by Molmil](/molmil-images/mine/2k1e) | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA | Descriptor: | water soluble analogue of potassium channel, KcsA | Authors: | Ma, D, Xu, Y, Tillman, T, Tang, P, Meirovitch, E, Eckenhoff, R, Carnini, A. | Deposit date: | 2008-02-29 | Release date: | 2008-11-11 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA. Proc.Natl.Acad.Sci.Usa, 105, 2008
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1XIM
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![BU of 1xim by Molmil](/molmil-images/mine/1xim) | ARGININE RESIDUES AS STABILIZING ELEMENTS IN PROTEINS | Descriptor: | COBALT (II) ION, D-XYLOSE ISOMERASE, Xylitol | Authors: | Mrabet, N.T, Van Denbroek, A, Van Den Brande, I, Stanssens, P, Laroche, Y, Lambeir, A.-M, Matthyssens, G, Jenkins, J, Chiadmi, M, Vantilbeurgh, H, Rey, F, Janin, J, Quax, W.J, Lasters, I, Demaeyer, M, Wodak, S.J. | Deposit date: | 1991-05-29 | Release date: | 1993-04-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Arginine residues as stabilizing elements in proteins. Biochemistry, 31, 1992
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2K59
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![BU of 2k59 by Molmil](/molmil-images/mine/2k59) | |
2KB1
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![BU of 2kb1 by Molmil](/molmil-images/mine/2kb1) | NMR studies of a channel protein without membrane: structure and dynamics of water-solubilized KcsA | Descriptor: | WSK3 | Authors: | Ma, D, Xu, Y, Tillman, T, Tang, P, Meirovitch, E, Eckenhoff, R, Carnini, A. | Deposit date: | 2008-11-19 | Release date: | 2008-12-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA Proc.Natl.Acad.Sci.USA, 105, 2008
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2K58
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![BU of 2k58 by Molmil](/molmil-images/mine/2k58) | |
2MAW
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![BU of 2maw by Molmil](/molmil-images/mine/2maw) | |
2VP8
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![BU of 2vp8 by Molmil](/molmil-images/mine/2vp8) | Structure of Mycobacterium tuberculosis Rv1207 | Descriptor: | 1,2-ETHANEDIOL, DIHYDROPTEROATE SYNTHASE 2 | Authors: | Gengenbacher, M, Xu, T, Niyomwattanakit, P, Spraggon, G, Dick, T. | Deposit date: | 2008-02-27 | Release date: | 2008-08-12 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Biochemical and Structural Characterization of the Putative Dihydropteroate Synthase Ortholog Rv1207 of Mycobacterium Tuberculosis. Fems Microbiol.Lett., 287, 2008
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4IRE
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![BU of 4ire by Molmil](/molmil-images/mine/4ire) | Crystal structure of GLIC with mutations at the loop C region | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ACETATE ION, OXALATE ION, ... | Authors: | Chen, Q, Pan, J, Liang, Y.H, Xu, Y, Tang, P. | Deposit date: | 2013-01-14 | Release date: | 2013-04-24 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Signal transduction pathways in the pentameric ligand-gated ion channels. Plos One, 8, 2013
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2Y1W
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![BU of 2y1w by Molmil](/molmil-images/mine/2y1w) | CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR | Descriptor: | 2-{4-[3-FLUORO-2-(2-METHOXYPHENYL)-1H-INDOL-5-YL] PIPERIDIN-1-YL}-N-METHYLETHANAMINE, HISTONE-ARGININE METHYLTRANSFERASE CARM1, SINEFUNGIN | Authors: | Sack, J.S, Thieffine, S, Bandiera, T, Fasolini, M, Duke, G.J, Jayaraman, L, Kish, K.F, Klei, H.E, Purandare, A.V, Rosettani, P, Troiani, S, Xie, D, Bertrand, J.A. | Deposit date: | 2010-12-10 | Release date: | 2011-03-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors Biochem.J., 436, 2011
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2Y1X
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![BU of 2y1x by Molmil](/molmil-images/mine/2y1x) | CRYSTAL STRUCTURE OF COACTIVATOR ASSOCIATED ARGININE METHYLTRANSFERASE 1 (CARM1) IN COMPLEX WITH SINEFUNGIN AND INDOLE INHIBITOR | Descriptor: | CHLORIDE ION, HISTONE-ARGININE METHYLTRANSFERASE CARM1, N-(3-{5-[5-(1H-INDOL-4-YL)-1,3,4-OXADIAZOL-2-YL]-3-(TRIFLUOROMETHYL)-1H-PYRAZOL-1-YL}BENZYL)-L-ALANINAMIDE, ... | Authors: | Sack, J.S, Thieffine, S, Bandiera, T, Fasolini, M, Duke, G.J, Jayaraman, L, Kish, K.F, Klei, H.E, Purandare, A.V, Rosettani, P, Troiani, S, Xie, D, Bertrand, J.A. | Deposit date: | 2010-12-10 | Release date: | 2011-03-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Basis for Carm1 Inhibition by Indole and Pyrazole Inhibitors Biochem.J., 436, 2011
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3XIM
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![BU of 3xim by Molmil](/molmil-images/mine/3xim) | ARGININE RESIDUES AS STABILIZING ELEMENTS IN PROTEINS | Descriptor: | COBALT (II) ION, D-XYLOSE ISOMERASE, sorbitol | Authors: | Mrabet, N.T, Van Denbroek, A, Van Den Brande, I, Stanssens, P, Laroche, Y, Lambeir, A.-M, Matthyssens, G, Jenkins, J, Chiadmi, M, Vantilbeurgh, H, Rey, F, Janin, J, Quax, W.J, Lasters, I, Demaeyer, M, Wodak, S.J. | Deposit date: | 1991-05-29 | Release date: | 1993-04-15 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Arginine residues as stabilizing elements in proteins. Biochemistry, 31, 1992
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1VRY
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![BU of 1vry by Molmil](/molmil-images/mine/1vry) | Second and Third Transmembrane Domains of the Alpha-1 Subunit of Human Glycine Receptor | Descriptor: | Glycine receptor alpha-1 chain | Authors: | Ma, D, Liu, Z, Li, L, Tang, P, Xu, Y. | Deposit date: | 2005-07-20 | Release date: | 2005-07-26 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Structure and Dynamics of the Second and Third Transmembrane Domains of Human Glycine Receptor. Biochemistry, 44, 2005
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2I7U
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![BU of 2i7u by Molmil](/molmil-images/mine/2i7u) | Structural and Dynamical Analysis of a Four-Alpha-Helix Bundle with Designed Anesthetic Binding Pockets | Descriptor: | Four-alpha-helix bundle | Authors: | Ma, D, Brandon, N.R, Cui, T, Bondarenko, V, Canlas, C, Johansson, J.S, Tang, P, Xu, Y. | Deposit date: | 2006-08-31 | Release date: | 2007-09-11 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Four-alpha-helix bundle with designed anesthetic binding pockets. Part I: structural and dynamical analyses. Biophys.J., 94, 2008
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2MHL
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![BU of 2mhl by Molmil](/molmil-images/mine/2mhl) | |