7QQR
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![BU of 7qqr by Molmil](/molmil-images/mine/7qqr) | SpCas9 bound to AAVS1 off-target5 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target5 non-target strand, AAVS1 off-target5 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQV
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![BU of 7qqv by Molmil](/molmil-images/mine/7qqv) | SpCas9 bound to FANCF off-target3 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target3 non-target strand, FANCF off-target3 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR5
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![BU of 7qr5 by Molmil](/molmil-images/mine/7qr5) | SpCas9 bound to FANCF off-target6 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target6 non-target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-17 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQO
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![BU of 7qqo by Molmil](/molmil-images/mine/7qqo) | SpCas9 bound to AAVS1 off-target1 DNA substrate | Descriptor: | AAVS1 off-target1 non-target strand, AAVS1 off-target1 target strand, AAVS1 sgRNA, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQQ
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![BU of 7qqq by Molmil](/molmil-images/mine/7qqq) | SpCas9 bound to AAVS1 off-target4 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target4 non-target strand, AAVS1 off-target4 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQU
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![BU of 7qqu by Molmil](/molmil-images/mine/7qqu) | SpCas9 bound to FANCF off-target2 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target2 non-target strand, FANCF off-target2 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQT
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![BU of 7qqt by Molmil](/molmil-images/mine/7qqt) | SpCas9 bound to FANCF off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target1 non-target strand, FANCF off-target1 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR8
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![BU of 7qr8 by Molmil](/molmil-images/mine/7qr8) | SpCas9 bound to PTPRC off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQP
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![BU of 7qqp by Molmil](/molmil-images/mine/7qqp) | SpCas9 bound to AAVS1 off-target3 DNA substrate | Descriptor: | 1,2-ETHANEDIOL, AAVS1 off-target3 non-target strand, AAVS1 off-target3 target strand, ... | Authors: | Pacesa, M, JInek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQS
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![BU of 7qqs by Molmil](/molmil-images/mine/7qqs) | SpCas9 bound to FANCF on-target DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF on-target non-target strand, FANCF on-target target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQX
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![BU of 7qqx by Molmil](/molmil-images/mine/7qqx) | SpCas9 bound to FANCF off-target5 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target5 non-target strand, FANCF off-target5 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR0
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![BU of 7qr0 by Molmil](/molmil-images/mine/7qr0) | SpCas9 bound to TRAC off-target1 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQZ
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![BU of 7qqz by Molmil](/molmil-images/mine/7qqz) | SpCas9 bound to FANCF off-target7 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target7 non-target strand, FANCF off-target7 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QQW
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![BU of 7qqw by Molmil](/molmil-images/mine/7qqw) | SpCas9 bound to FANCF off-target4 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, FANCF off-target4 non-target strand, FANCF off-target4 target strand, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR1
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![BU of 7qr1 by Molmil](/molmil-images/mine/7qr1) | SpCas9 bound to TRAC off-target2 DNA substrate | Descriptor: | CRISPR-associated endonuclease Cas9/Csn1, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7QR7
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![BU of 7qr7 by Molmil](/molmil-images/mine/7qr7) | SpCas9 bound to AAVS1 off-target2 DNA substrate | Descriptor: | AAVS1 off-target2 non-target strand, AAVS1 off-target2 target strand, AAVS1 sgRNA, ... | Authors: | Pacesa, M, JInek, M. | Deposit date: | 2022-01-10 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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7PLH
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![BU of 7plh by Molmil](/molmil-images/mine/7plh) | Scytonema hofmannii TnsC bound to AMPPNP and DNA | Descriptor: | DNA (5'-D(P*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*TP*AP*T)-3'), MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Querques, I, Jinek, M. | Deposit date: | 2021-08-31 | Release date: | 2021-12-01 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Target site selection and remodelling by type V CRISPR-transposon systems. Nature, 599, 2021
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7ZYH
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![BU of 7zyh by Molmil](/molmil-images/mine/7zyh) | Crystal structure of human CPSF30 in complex with hFip1 | Descriptor: | Cleavage and polyadenylation specificity factor subunit 4, Isoform 4 of Pre-mRNA 3'-end-processing factor FIP1, ZINC ION | Authors: | Muckenfuss, L.M, Jinek, M, Migenda Herranz, A.C, Clerici, M. | Deposit date: | 2022-05-24 | Release date: | 2022-09-14 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Elife, 11, 2022
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7ZO1
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![BU of 7zo1 by Molmil](/molmil-images/mine/7zo1) | SpCas9 bound to CD34 off-target9 DNA substrate | Descriptor: | CD34 off-target9 DNA non-target strand, CD34 off-target9 DNA target strand, CD34 sgRNA, ... | Authors: | Pacesa, M, Jinek, M. | Deposit date: | 2022-04-23 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for Cas9 off-target activity. Cell, 185, 2022
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8BD5
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![BU of 8bd5 by Molmil](/molmil-images/mine/8bd5) | Cas12k-sgRNA-dsDNA-S15-TniQ-TnsC transposon recruitment complex | Descriptor: | 30S ribosomal protein S15, ADENOSINE-5'-TRIPHOSPHATE, DNA non-target strand, ... | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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8BD4
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![BU of 8bd4 by Molmil](/molmil-images/mine/8bd4) | TniQ-capped Tns-ATP-dsDNA complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(P*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*CP*GP*AP*TP*C)-3'), MAGNESIUM ION, ... | Authors: | Querques, I, Schmitz, M, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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8BD6
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![BU of 8bd6 by Molmil](/molmil-images/mine/8bd6) | Cas12k-sgRNA-dsDNA-TnsC non-productive complex. | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cas12k, DNA, ... | Authors: | Schmitz, M, Querques, I, Oberli, S, Chanez, C, Jinek, M. | Deposit date: | 2022-10-18 | Release date: | 2022-12-28 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for the assembly of the type V CRISPR-associated transposon complex. Cell, 185, 2022
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7ZY4
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![BU of 7zy4 by Molmil](/molmil-images/mine/7zy4) | |
8BQF
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![BU of 8bqf by Molmil](/molmil-images/mine/8bqf) | Adenylate Kinase L107I MUTANT | Descriptor: | Adenylate kinase, BIS(ADENOSINE)-5'-PENTAPHOSPHATE | Authors: | Scheerer, D, Adkar, B.V, Bhattacharyya, S, Levy, D, Iljina, M, Iljina, I, Dym, O, Haran, G, Shakhnovich, E.I. | Deposit date: | 2022-11-21 | Release date: | 2023-05-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Allosteric communication between ligand binding domains modulates substrate inhibition in adenylate kinase. Proc.Natl.Acad.Sci.USA, 120, 2023
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1GEA
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![BU of 1gea by Molmil](/molmil-images/mine/1gea) | RECEPTOR-BOUND CONFORMATION OF PACAP21 | Descriptor: | PITUITARY ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE | Authors: | Inooka, H, Ohtaki, T, Kitahara, O, Ikegami, T, Endo, S, Kitada, C, Ogi, K, Onda, H, Fujino, M, Shirakawa, M. | Deposit date: | 2000-10-20 | Release date: | 2001-04-20 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Conformation of a peptide ligand bound to its G-protein coupled receptor. Nat.Struct.Biol., 8, 2001
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