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Crystal structure of a domain of unknown function (DUF1537) from Bordetella bronchiseptica (BB3215), Target EFI-511620, with bound citrate, domain swapped dimer, space group C2221
Descriptor:	CHLORIDE ION, CITRIC ACID, SULFATE ION, ...
Authors:	Vetting, M.W, Al Obaidi, N.F, Toro, R, Morisco, L.L, Benach, J, Wasserman, S.R, Attonito, J.D, Scott Glenn, A, Chamala, S, Chowdhury, S, Lafleur, J, Love, J, Seidel, R.D, Whalen, K.L, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI)
Deposit date:	2014-12-30
Release date:	2015-03-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars. Proc.Natl.Acad.Sci.USA, 113, 2016

8WCT

The crystal structure of the CHASE4 domain of iron-sensetive membrane protein (IsmP,Uniprot ID:Q9I243)
Descriptor:	Bifunctional diguanylate cyclase/phosphodiesterase, GLYCEROL
Authors:	Wang, C.C.
Deposit date:	2023-09-13
Release date:	2024-02-14
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	A c-di-GMP signaling module controls responses to iron in Pseudomonas aeruginosa. Nat Commun, 15, 2024

8KER

Structure of SARS-CoV-2 XBB Variant Spike protein complexed with broadly neutralizing antibody PW5-535
Descriptor:	PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-13
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (2.95 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KDT

The local refined map of SARS-CoV Spike protein complexed with antibody PW5-5
Descriptor:	PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-10
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.04 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KDS

Trimer state of SARS-CoV Spike protein complexed with antibody PW5-535
Descriptor:	PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-10
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.05 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KEP

The local refined map of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570
Descriptor:	PW5-570 heavy chain, PW5-570 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-13
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (2.93 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KEK

Monomer state of SARS-CoV Spike protein complexed with antibody PW5-535
Descriptor:	PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-11
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.54 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KDM

Structure of SARS-CoV Spike protein complexed with antibody PW5-5
Descriptor:	PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-09
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (2.87 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KDR

The local refined map of SARS-CoV-2 XBB Variant Spike protein complexed with antibody PW5-535
Descriptor:	PW5-535 heavy chain, PW5-535 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-10
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KEJ

Monomer state of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5
Descriptor:	PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-11
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.73 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KEO

Structure of SARS-CoV-2 Omicron BA.1 Spike complexed with antibody PW5-570
Descriptor:	PW5-570 heavy chain, PW5-570 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-13
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (2.78 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

8KEQ

State 1 of SARS-CoV-2 XBB Variant Spike protein trimer complexed with antibody PW5-5
Descriptor:	PW5-5 heavy chain, PW5-5 light chain, Spike glycoprotein
Authors:	Sun, L, Mao, Q, Wang, Y.
Deposit date:	2023-08-13
Release date:	2024-08-14
Method:	ELECTRON MICROSCOPY (3.14 Å)
Cite:	Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination. Cell Discov, 10, 2024

6YQN

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW9
Descriptor:	1,2-ETHANEDIOL, Bromodomain-containing protein 4, ~{N}-(2-aminophenyl)-4-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]t rideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]benzamide
Authors:	Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2020-04-17
Release date:	2020-05-06
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.05 Å)
Cite:	Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020

6YQP

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW22
Descriptor:	(~{E})-3-[4-[[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6 ),4,7,10,12-pentaen-9-yl]ethanoylamino]methyl]phenyl]-~{N}-oxidanyl-prop-2-enamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4
Authors:	Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2020-04-17
Release date:	2020-05-27
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020

6YQO

Crystal structure of the first bromodomain of human BRD4 in complex with the dual inhibitor TW12
Descriptor:	(S)-N1-(4-(2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetamido)phenyl)-N8-hydroxyoctanediamide, 1,2-ETHANEDIOL, Bromodomain-containing protein 4
Authors:	Joerger, A.C, Balourdas, D.I, Weiser, T, Chatterjee, D, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2020-04-17
Release date:	2020-05-06
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.07 Å)
Cite:	Characterization of a dual BET/HDAC inhibitor for treatment of pancreatic ductal adenocarcinoma. Int.J.Cancer, 147, 2020

1DYD

DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994

1DYC

DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994

1DYB

DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994

1L69

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1991-09-23
Release date:	1991-10-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1DYA

DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994

1DYE

DETERMINATION OF ALPHA-HELIX PROPENSITY WITHIN THE CONTEXT OF A FOLDED PROTEIN: SITES 44 AND 131 IN BACTERIOPHAGE T4 LYSOZYME
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1993-05-13
Release date:	1993-10-31
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J.Mol.Biol., 235, 1994

1L74

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1991-09-23
Release date:	1991-10-15
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L71

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1991-09-23
Release date:	1991-10-15
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L73

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1991-09-23
Release date:	1991-10-15
Last modified:	2020-07-22
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

1L72

MULTIPLE STABILIZING ALANINE REPLACEMENTS WITHIN ALPHA-HELIX 126-134 OF T4 LYSOZYME HAVE INDEPENDENT, ADDITIVE EFFECTS ON BOTH STRUCTURE AND STABILITY
Descriptor:	BETA-MERCAPTOETHANOL, CHLORIDE ION, LYSOZYME
Authors:	Zhang, X, Matthews, B.W.
Deposit date:	1991-09-23
Release date:	1991-10-15
Last modified:	2017-11-29
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Multiple alanine replacements within alpha-helix 126-134 of T4 lysozyme have independent, additive effects on both structure and stability. Protein Sci., 1, 1992

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