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Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Proline and AMP
Descriptor:	ADENOSINE MONOPHOSPHATE, Aminoacyl-tRNA synthetase, PHOSPHATE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-12-10
Release date:	2016-11-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Proline and AMP to be published

5F9Z

Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP
Descriptor:	7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, Aminoacyl-tRNA synthetase, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-12-10
Release date:	2016-11-16
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal Structure of Prolyl-tRNA Synthetase from Cryptosporidium parvum complexed with Halofuginone and AMPPNP to be published

6UYN

Crystal structure of influenza A virus hemagglutinin from A/Ohio/09/2015 bound to the stalk-binding CR6261 antibody Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2019-11-13
Release date:	2020-09-02
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	Crystal structure of influenza A virus hemagglutinin from A/Ohio/09/2015 bound to the stalk-binding CR6261 antibody Fab To Be Published

6VS4

Crystal structure of ADP RIBOSYLATION FACTOR-LIKE GTP BINDING PROTEIN /Small COPII coat GTPase SAR1 from Encephalitozoon cuniculi in complex with GDP
Descriptor:	DI(HYDROXYETHYL)ETHER, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2020-02-10
Release date:	2020-03-11
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Crystal structure of ADP RIBOSYLATION FACTOR-LIKE GTP BINDING PROTEIN /Small COPII coat GTPase SAR1 from Encephalitozoon cuniculi in complex with GDP to be published

6BN2

Crystal structure of Acetyl-CoA acetyltransferase from Elizabethkingia anophelis NUHP1
Descriptor:	Acetyl-CoA acetyltransferase, CALCIUM ION, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-11-15
Release date:	2018-01-17
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Crystal structure of Acetyl-CoA acetyltransferase from Elizabethkingia anophelis NUHP1 To be Published

4WTD

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS AND DELTA8 BETA HAIRPIN LOOP DELETION IN COMPLEX WITH ADP, MN2+ AND SYMMETRICAL PRIMER TEMPLATE 5'-AUAAAUUU
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, MANGANESE (II) ION, ...
Authors:	Edwards, T.E, Fox III, D, Appleby, T.C.
Deposit date:	2014-10-29
Release date:	2015-02-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015

4WTM

CRYSTAL STRUCTURE OF HCV NS5B GENOTYPE 2A JFH-1 ISOLATE WITH S15G E86Q E87Q C223H V321I MUTATIONS IN COMPLEX WITH RNA TEMPLATE 5'-UAGG, RNA PRIMER 5'-PCC, MN2+, AND UDP
Descriptor:	CHLORIDE ION, MANGANESE (II) ION, RNA PRIMER CC, ...
Authors:	Edwards, T.E, Appleby, T.C, Fox III, D.
Deposit date:	2014-10-30
Release date:	2015-02-11
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Structural basis for RNA replication by the hepatitis C virus polymerase. Science, 347, 2015

5KF0

Crystal structure of an Aldedhyde dehydrogenase from Burkholderia vietnamiensis
Descriptor:	(4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2016-06-10
Release date:	2016-11-09
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Crystal structure of an Aldedhyde dehydrogenase from Burkholderia vietnamiensis to be published

7KP7

asymmetric mTNF-alpha hTNFR1 complex
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, Tumor necrosis factor, ...
Authors:	Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:	2020-11-10
Release date:	2021-01-13
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.65 Å)
Cite:	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021

7KP8

asymmetric mTNF-alpha hTNFR1 complex
Descriptor:	1-{[2-(difluoromethoxy)phenyl]methyl}-2-methyl-6-[6-(piperazin-1-yl)pyridin-3-yl]-1H-benzimidazole, Tumor necrosis factor, Tumor necrosis factor receptor superfamily member 1A
Authors:	Arakaki, T.L, Fox III, D, Edwards, T.E, Foley, A, Ceska, T.
Deposit date:	2020-11-10
Release date:	2021-01-13
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (3.15 Å)
Cite:	Structural insights into the disruption of TNF-TNFR1 signalling by small molecules stabilising a distorted TNF. Nat Commun, 12, 2021

4O0K

Crystal structure of 1-pyrroline-4-hydroxy-2-carboxylate deaminase from Brucella melitensis with covalently bound substrate
Descriptor:	1,2-ETHANEDIOL, Dihydrodipicolinate synthetase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-12-13
Release date:	2014-01-15
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Crystal structure of 1-pyrroline-4-hydroxy-2-carboxylate deaminase from Brucella melitensis with covalently bound substrate To be Published

4IXO

X-ray structure of NifS-like protein from Rickettsia africae ESF-5
Descriptor:	1,2-ETHANEDIOL, CALCIUM ION, NifS-like protein
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2013-01-27
Release date:	2013-02-27
Last modified:	2023-12-06
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	X-ray structure of NifS-like protein from Rickettsia africae ESF-5 To be Published

4XKZ

Crystal structure of the C-terminal anticodon loop binding domain of a valyl-tRNA synthetase from Pseudomonas aeruginosa
Descriptor:	IODIDE ION, TRIETHYLENE GLYCOL, Valine-tRNA ligase
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2015-01-12
Release date:	2015-02-11
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Crystal structure of the C-terminal anticodon loop binding domain of a valyl-tRNA synthetase from Pseudomonas aeruginosa. To Be Published

4HVT

Structure of a Post-proline cleaving enzyme from Rickettsia typhi
Descriptor:	1,2-ETHANEDIOL, CHLORIDE ION, Post-proline cleaving enzyme
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2012-11-07
Release date:	2012-11-28
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.7 Å)
Cite:	Structure of a Post-proline cleaving enzyme from Rickettsia typhi To be Published

5VBF

Crystal structure of succinate semialdehyde dehydrogenase from Burkholderia vietnamiensis
Descriptor:	2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FORMIC ACID, GLYCEROL, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2017-03-29
Release date:	2017-04-12
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Crystal structure of succinate semialdehyde dehydrogenase from Burkholderia vietnamiensis to be published

5SCY

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1198
Descriptor:	1,2-ETHANEDIOL, 1-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)piperidine-4-carboxylic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1198 to be published

5SD0

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225
Descriptor:	1,2-ETHANEDIOL, 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)propan-1-ol, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1225 to be published

5SCS

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-781
Descriptor:	3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(propane-2-sulfonyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-781 to be published

5SCZ

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1224
Descriptor:	(2E)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}pyridin-3-yl)prop-2-en-1-ol, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.75 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1224 to be published

5SCT

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783
Descriptor:	3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-N-(dimethylsulfamoyl)propanamide, Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-783 to be published

5SD3

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088
Descriptor:	1,2-ETHANEDIOL, 3-{2-[(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]methyl}oxetan-3-yl)methoxy]phenyl}propanoic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.3 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1088 to be published

5SCV

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889
Descriptor:	6-ethyl-5-(4-{3-[3-(1H-tetrazol-5-yl)propyl]phenoxy}butoxy)pyrimidine-2,4-diamine, CHLORIDE ION, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-889 to be published

5SD5

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230
Descriptor:	1,2-ETHANEDIOL, 1-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}-4-methylphenyl)azetidine-3-carboxylic acid, Dihydrofolate reductase, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (1.2 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1230 to be published

5SD8

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture)
Descriptor:	(2R)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-1190 (racemic mixture) to be published

5SDA

Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774
Descriptor:	(2R)-3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)-2-methylpropanamide, 1,2-ETHANEDIOL, CHLORIDE ION, ...
Authors:	Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:	2021-12-20
Release date:	2022-02-09
Last modified:	2024-05-22
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Crystal Structure of Dihydrofolate Reductase from Homo sapiens bound to NADP and SDDC Inhibitor SDDC-774 to be published

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