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4YYN
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BU of 4yyn by Molmil
Crystal structure of TAF1 BD2 Bromodomain bound to a crotonyllysine peptide
Descriptor: Histone H4, Transcription initiation factor TFIID subunit 1
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-24
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YY6
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BU of 4yy6 by Molmil
Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYD
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BU of 4yyd by Molmil
Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYH
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BU of 4yyh by Molmil
Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYK
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BU of 4yyk by Molmil
Crystal structure of BRD9 Bromodomain bound to a crotonyllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-24
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYM
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BU of 4yym by Molmil
Crystal structure of TAF1 BD2 Bromodomain bound to a butyryllysine peptide
Descriptor: CALCIUM ION, Histone H4, Transcription initiation factor TFIID subunit 1
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-24
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYG
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BU of 4yyg by Molmil
Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYJ
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BU of 4yyj by Molmil
Crystal structure of BRD9 Bromodomain bound to a butyryllysine peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
4YYI
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BU of 4yyi by Molmil
Crystal structure of BRD9 Bromodomain bound to an acetylated peptide
Descriptor: Bromodomain-containing protein 9, Histone H4
Authors:Tang, Y, Bellon, S, Cochran, A.G, Poy, F.
Deposit date:2015-03-23
Release date:2015-09-16
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Subset of Human Bromodomains Recognizes Butyryllysine and Crotonyllysine Histone Peptide Modifications.
Structure, 23, 2015
3D9V
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BU of 3d9v by Molmil
CRYSTAL STRUCTURE OF ROCK I BOUND TO H-1152P A DI-METHYLATED VARIANT OF FASUDIL
Descriptor: (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, Rho-associated protein kinase 1
Authors:Jacobs, M.
Deposit date:2008-05-27
Release date:2008-06-10
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The structure of dimeric ROCK I reveals the mechanism for ligand selectivity.
J.Biol.Chem., 281, 2006
3G7B
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BU of 3g7b by Molmil
Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
Descriptor: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate
Authors:Wei, Y, Charisfon, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G7E
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BU of 3g7e by Molmil
Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor
Descriptor: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate
Authors:Wei, Y, Charifson, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G75
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BU of 3g75 by Molmil
Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor
Descriptor: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B
Authors:Wei, Y, Charifson, P.
Deposit date:2009-02-09
Release date:2010-02-09
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
4YVC
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BU of 4yvc by Molmil
ROCK 1 bound to thiazole inhibitor
Descriptor: 2-fluoro-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide, Rho-associated protein kinase 1
Authors:Jacobs, M.D.
Deposit date:2015-03-19
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
J.Med.Chem., 58, 2015
4YVE
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BU of 4yve by Molmil
ROCK 1 bound to methoxyphenyl thiazole inhibitor
Descriptor: 2-(3-methoxyphenyl)-N-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]acetamide, Rho-associated protein kinase 1
Authors:Jacobs, M.D.
Deposit date:2015-03-19
Release date:2015-06-10
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
J.Med.Chem., 58, 2015
5BML
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BU of 5bml by Molmil
ROCK 1 bound to a pyridine thiazole inhibitor
Descriptor: N-[4-(2-fluoropyridin-4-yl)thiophen-2-yl]-2-{3-[(methylsulfonyl)amino]phenyl}acetamide, Rho-associated protein kinase 1
Authors:Jacobs, M.D.
Deposit date:2015-05-22
Release date:2015-06-10
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Design, Synthesis, and Structure-Activity Relationships of Pyridine-Based Rho Kinase (ROCK) Inhibitors.
J.Med.Chem., 58, 2015
3FC1
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BU of 3fc1 by Molmil
Crystal structure of p38 kinase bound to pyrimido-pyridazinone inhibitor
Descriptor: 5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one, CHLORIDE ION, Mitogen-activated protein kinase 14
Authors:Jacobs, M.D, Bellon, S.
Deposit date:2008-11-20
Release date:2008-12-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Evaluating the molecular mechanics poisson-boltzmann surface area free energy method using a congeneric series of ligands to p38 MAP kinase.
J.Med.Chem., 48, 2005
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