3NSC
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![BU of 3nsc by Molmil](/molmil-images/mine/3nsc) | C500S MUTANT OF CueO BOUND TO Cu(II) | Descriptor: | ACETATE ION, Blue copper oxidase cueO, COPPER (II) ION, ... | Authors: | Roberts, S.A, Montfort, W.R, Singh, S.K. | Deposit date: | 2010-07-01 | Release date: | 2011-08-17 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
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5K3Y
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![BU of 5k3y by Molmil](/molmil-images/mine/5k3y) | Crystal structure of AuroraB/INCENP in complex with BI 811283 | Descriptor: | Aurora kinase B-A, Inner centromere protein A, N-methyl-N-(1-methylpiperidin-4-yl)-4-{[4-({(1R,2S)-2-[(propan-2-yl)carbamoyl]cyclopentyl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}benzamide | Authors: | Bader, G, Zahn, S.K, Zoephel, A. | Deposit date: | 2016-05-20 | Release date: | 2016-08-17 | Last modified: | 2022-12-07 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
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6WP0
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![BU of 6wp0 by Molmil](/molmil-images/mine/6wp0) | |
6WP2
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![BU of 6wp2 by Molmil](/molmil-images/mine/6wp2) | |
3NT0
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![BU of 3nt0 by Molmil](/molmil-images/mine/3nt0) | |
3NSD
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![BU of 3nsd by Molmil](/molmil-images/mine/3nsd) | Silver bound to the multicopper oxidase CueO (untagged) | Descriptor: | Blue copper oxidase cueO, COPPER (II) ION, OXYGEN ATOM, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2010-07-01 | Release date: | 2011-08-17 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
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6WNJ
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![BU of 6wnj by Molmil](/molmil-images/mine/6wnj) | |
3OD3
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![BU of 3od3 by Molmil](/molmil-images/mine/3od3) | CueO at 1.1 A resolution including residues in previously disordered region | Descriptor: | 1,2-ETHANEDIOL, Blue copper oxidase cueO, COPPER (II) ION, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2010-08-10 | Release date: | 2011-09-07 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Crystal structures of multicopper oxidase CueO bound to copper(I) and silver(I): functional role of a methionine-rich sequence. J. Biol. Chem., 286, 2011
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6YIO
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![BU of 6yio by Molmil](/molmil-images/mine/6yio) | CRYSTAL STRUCTURE OF FAB RG6292 IN COMPLEX WITH CD25 ECD | Descriptor: | FAB FRAGMENT HEAVY CHAIN, FAB FRGAMENT LIGHT CHAIN, Interleukin-2 receptor subunit alpha | Authors: | Benz, J, Koll, H, Leibrock, L. | Deposit date: | 2020-04-01 | Release date: | 2020-11-11 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | CD25-T reg -depleting antibodies preserving IL-2 signaling on effector T cells enhance effector activation and antitumor immunity. Nat Cancer, 1, 2020
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3QQX
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![BU of 3qqx by Molmil](/molmil-images/mine/3qqx) | Reduced Native Intermediate of the Multicopper Oxidase CueO | Descriptor: | Blue copper oxidase CueO, COPPER (I) ION, COPPER (II) ION, ... | Authors: | Montfort, W.R, Roberts, S.A, Singh, S.K. | Deposit date: | 2011-02-16 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | CueO E506D Mutant: Crystal Structure of Reduced Native Intermediate, Kinetics, and Impairment of Product Release To be Published
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5KAE
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5DE1
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![BU of 5de1 by Molmil](/molmil-images/mine/5de1) | Crystal structure of human IDH1 in complex with GSK321A | Descriptor: | (7R)-1-(4-fluorobenzyl)-N-{3-[(1S)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Concha, N.O, Smallwood, A, Qi, H. | Deposit date: | 2015-08-25 | Release date: | 2015-10-07 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat.Chem.Biol., 11, 2015
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8D6H
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![BU of 8d6h by Molmil](/molmil-images/mine/8d6h) | Q108K:K40L:T51C:T53A:R58L:Q38F:Q4F mutant of hCRBPII bound to synthetic fluorophore CM1V after UV irradiation | Descriptor: | (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, ACETATE ION, ... | Authors: | Bingham, C.R, Geiger, J.H, Borhan, B. | Deposit date: | 2022-06-06 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
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8D6N
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![BU of 8d6n by Molmil](/molmil-images/mine/8d6n) | Q108K:K40L:T53A:R58L:Q38F:Q4F mutant of hCRBPII bound to synthetic fluorophore CM1V | Descriptor: | (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, ACETATE ION, ... | Authors: | Bingham, C.R, Geiger, J.H, Borhan, B. | Deposit date: | 2022-06-06 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
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7OOJ
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![BU of 7ooj by Molmil](/molmil-images/mine/7ooj) | Structure of D-Thr53 Ubiquitin | Descriptor: | CADMIUM ION, Ubiquitin | Authors: | Becker, S. | Deposit date: | 2021-05-27 | Release date: | 2022-05-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A litmus test for classifying recognition mechanisms of transiently binding proteins. Nat Commun, 13, 2022
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8DB2
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![BU of 8db2 by Molmil](/molmil-images/mine/8db2) | Q108K:K40L:T51C:T53A:R58L:Q38F mutant of hCRBPII bound to synthetic fluorophore CM1V | Descriptor: | (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, Retinol-binding protein 2 | Authors: | Bingham, C.R, Geiger, J.H, Borhan, B, Staples, R. | Deposit date: | 2022-06-14 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
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8DN1
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![BU of 8dn1 by Molmil](/molmil-images/mine/8dn1) | Q108K:K40L:T51C:T53A:R58L:Q38F:Q4F mutant of hCRBPII bound to synthetic fluorophore CM1V at pH 7.2 | Descriptor: | (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, GLYCEROL, ... | Authors: | Bingham, C.R, Borhan, B, Geiger, J.H. | Deposit date: | 2022-07-10 | Release date: | 2023-02-01 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
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8D6L
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![BU of 8d6l by Molmil](/molmil-images/mine/8d6l) | Q108K:K40L:T51C:T53A:R58L:Q38F:Q4F mutant of hCRBPII bound to synthetic fluorophore CM1V | Descriptor: | (2E)-3-[7-(diethylamino)-2-oxo-2H-1-benzopyran-3-yl]prop-2-enal, bound form, GLYCEROL, ... | Authors: | Bingham, C.R, Geiger, J.H, Borhan, B. | Deposit date: | 2022-06-06 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | Light controlled reversible Michael addition of cysteine: a new tool for dynamic site-specific labeling of proteins. Analyst, 148, 2023
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7B3Y
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![BU of 7b3y by Molmil](/molmil-images/mine/7b3y) | Structure of a nanoparticle for a COVID-19 vaccine candidate | Descriptor: | Fibronectin binding protein,2-dehydro-3-deoxyphosphogluconate aldolase/4-hydroxy-2-oxoglutarate aldolase | Authors: | Duyvesteyn, H.M.E, Stuart, D.I. | Deposit date: | 2020-12-01 | Release date: | 2021-01-13 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | A COVID-19 vaccine candidate using SpyCatcher multimerization of the SARS-CoV-2 spike protein receptor-binding domain induces potent neutralising antibody responses. Nat Commun, 12, 2021
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5LWO
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![BU of 5lwo by Molmil](/molmil-images/mine/5lwo) | Structure of Spin-labelled T4 lysozyme mutant L115C-R119C-R1 at 100K | Descriptor: | 2-HYDROXYETHYL DISULFIDE, BETA-MERCAPTOETHANOL, CHLORIDE ION, ... | Authors: | Loll, B, Consentius, P, Gohlke, U, Mueller, R, Kaupp, M, Heinemann, U, Wahl, M.C, Risse, T. | Deposit date: | 2016-09-18 | Release date: | 2017-03-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.183 Å) | Cite: | Internal Dynamics of the 3-Pyrroline-N-Oxide Ring in Spin-Labeled Proteins. J Phys Chem Lett, 8, 2017
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5EYK
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![BU of 5eyk by Molmil](/molmil-images/mine/5eyk) | CRYSTAL STRUCTURE OF AURORA B IN COMPLEX WITH BI 847325 | Descriptor: | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, Aurora kinase B-A, Inner centromere protein A | Authors: | Bader, G, Zoephel, A. | Deposit date: | 2015-11-25 | Release date: | 2016-08-17 | Last modified: | 2016-10-19 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
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5EDS
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![BU of 5eds by Molmil](/molmil-images/mine/5eds) | Crystal structure of human PI3K-gamma in complex with benzimidazole inhibitor 5 | Descriptor: | 4-azanyl-6-[[(1~{S})-1-[6-fluoranyl-1-(3-methylsulfonylphenyl)benzimidazol-2-yl]ethyl]amino]pyrimidine-5-carbonitrile, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | Authors: | Whittington, D.A, Tang, J, Yakowec, P. | Deposit date: | 2015-10-21 | Release date: | 2015-12-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Discovery, Optimization, and in Vivo Evaluation of Benzimidazole Derivatives AM-8508 and AM-9635 as Potent and Selective PI3K delta Inhibitors. J.Med.Chem., 59, 2016
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5EYM
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![BU of 5eym by Molmil](/molmil-images/mine/5eym) | MEK1 IN COMPLEX WITH BI 847325 | Descriptor: | 3-[(3~{Z})-3-[[[4-[(dimethylamino)methyl]phenyl]amino]-phenyl-methylidene]-2-oxidanylidene-1~{H}-indol-6-yl]-~{N}-ethyl-prop-2-ynamide, CALCIUM ION, Dual specificity mitogen-activated protein kinase kinase 1 | Authors: | Bader, G, Reiser, U, Zahn, S.K, Treu, M. | Deposit date: | 2015-11-25 | Release date: | 2016-08-17 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Pharmacological Profile of BI 847325, an Orally Bioavailable, ATP-Competitive Inhibitor of MEK and Aurora Kinases. Mol.Cancer Ther., 15, 2016
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5CES
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6WPW
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![BU of 6wpw by Molmil](/molmil-images/mine/6wpw) | GCGR-Gs signaling complex bound to a designed glucagon derivative | Descriptor: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K. | Deposit date: | 2020-04-28 | Release date: | 2020-08-12 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into differences in G protein activation by family A and family B GPCRs. Science, 369, 2020
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