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1R0V
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BU of 1r0v by Molmil
Structure Determination of the Dimeric Endonuclease in a Pseudo-face-centerd P21212 space group
Descriptor: tRNA-intron endonuclease
Authors:Li, H, Zhang, Y.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space group P2(1)2(1)2.
Acta Crystallogr.,Sect.D, 60, 2004
1R11
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BU of 1r11 by Molmil
Structure Determination of the Dimeric Endonuclease in a Pseudo-face-centerd P21 space group
Descriptor: tRNA-intron endonuclease
Authors:Li, H, Zhang, Y.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space group P2(1)2(1)2.
Acta Crystallogr.,Sect.D, 60, 2004
7W29
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BU of 7w29 by Molmil
Crystal Structure of SETD3-SAH in complex with betaA-Orn73 peptide
Descriptor: Actin, cytoplasmic 1, N-terminally processed, ...
Authors:Li, H, Ma, H.
Deposit date:2021-11-23
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.
Protein Sci., 31, 2022
1R21
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BU of 1r21 by Molmil
Solution Structure of human Ki67 FHA Domain
Descriptor: Antigen Ki-67
Authors:Byeon, I.J, Li, H, Tsai, M.D.
Deposit date:2003-09-25
Release date:2003-12-30
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of Human Ki67 FHA Domain and its Binding to a Phosphoprotein Fragment from hNIFK Reveal Unique Recognition Sites and New Views to the Structural Basis of FHA Domain Functions
J.Mol.Biol., 335, 2004
7W28
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BU of 7w28 by Molmil
Crystal Structure of SETD3-SAH in complex with betaA-4PyrAla73 peptide
Descriptor: Actin, cytoplasmic 1, Histone-lysine N-methyltransferase setd3, ...
Authors:Li, H, Ma, H.
Deposit date:2021-11-22
Release date:2022-10-05
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Histidine methyltransferase SETD3 methylates structurally diverse histidine mimics in actin.
Protein Sci., 31, 2022
9IVW
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BU of 9ivw by Molmil
Structure of Adenovirus serotype 2 100K
Descriptor: Shutoff protein
Authors:Liu, Q, Li, H, Xiang, Y.
Deposit date:2024-07-24
Release date:2025-05-14
Method:ELECTRON MICROSCOPY (3.79 Å)
Cite:Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus.
Nat Commun, 16, 2025
9IVX
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BU of 9ivx by Molmil
CryoEM structure of Adenovirus serotype 3 premature hexon in complex with Adenovirus serotype 2 100K
Descriptor: Hexon protein, Shutoff protein
Authors:Liu, Q, Li, H, Xiang, Y.
Deposit date:2024-07-24
Release date:2025-05-14
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus.
Nat Commun, 16, 2025
9IW0
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BU of 9iw0 by Molmil
Structure of Adenovirus serotype 3 mature hexon
Descriptor: Hexon protein
Authors:Liu, Q, Li, H, Xiang, Y.
Deposit date:2024-07-24
Release date:2025-05-14
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Molecular mechanisms of the viral encoded chaperone 100K in capsid folding and assembly of adenovirus.
Nat Commun, 16, 2025
4LUW
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BU of 4luw by Molmil
Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-((((3R,5S)-5-(((6-amino-4-methylpyridin-2-yl)methoxy)methyl)pyrrolidin-3-yl)oxy)methyl)-4-methylpyridin-2-amine
Descriptor: 5,6,7,8-TETRAHYDROBIOPTERIN, 6-({[(3R,5S)-5-{[(6-amino-4-methylpyridin-2-yl)methoxy]methyl}pyrrolidin-3-yl]oxy}methyl)-4-methylpyridin-2-amine, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2013-07-25
Release date:2013-10-23
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Proc.Natl.Acad.Sci.USA, 110, 2013
4MPZ
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BU of 4mpz by Molmil
Crystal structure of TCP10c domain of Drosophila melanogaster Sas-4
Descriptor: IMIDAZOLE, Sas-4
Authors:Li, H, Zheng, X.
Deposit date:2013-09-14
Release date:2014-01-01
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:The conserved TCP domain of Sas-4/CPAP is essential for Peri-centriolar material tethering during centrosome biogenesis
Proc.Natl.Acad.Sci.USA, 2014
9CW5
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BU of 9cw5 by Molmil
Structure of human endothelial nitric oxide synthase heme domain bound with 4-methyl-6-(3-((methylamino)methyl)-5-(trifluoromethyl)phenyl)pyridin-2-amine dihydrochloride
Descriptor: (6P)-4-methyl-6-{3-[(methylamino)methyl]-5-(trifluoromethyl)phenyl}pyridin-2-amine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVQ
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BU of 9cvq by Molmil
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain bound with 6-(5-((3,3-difluoroazetidin-1-yl)methyl)-2,3-difluorophenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{5-[(3,3-difluoroazetidin-1-yl)methyl]-2,3-difluorophenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CW1
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BU of 9cw1 by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 6-(2,3-difluoro-5-(2-(methylamino)ethyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{2,3-difluoro-5-[2-(methylamino)ethyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVJ
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BU of 9cvj by Molmil
Structure of rat nNOS R349A mutant heme domain bound with 4-methyl-6-(3-((methylamino)methyl)-5-(trifluoromethyl)phenyl)pyridin-2-amine dihydrochloride
Descriptor: (6P)-4-methyl-6-{3-[(methylamino)methyl]-5-(trifluoromethyl)phenyl}pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVW
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BU of 9cvw by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant bound with 6-(3-chloro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6P)-6-{3-chloro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVI
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BU of 9cvi by Molmil
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain bound with 4-methyl-6-(3-((methylamino)methyl)phenyl)pyridin-2-amine dihydrochloride
Descriptor: 4-methyl-6-{3-[(methylamino)methyl]phenyl}pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVU
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BU of 9cvu by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 4-methyl-6-(3-((methylamino)methyl)-5-(trifluoromethyl)phenyl)pyridin-2-amine dihydrochloride
Descriptor: (6P)-4-methyl-6-{3-[(methylamino)methyl]-5-(trifluoromethyl)phenyl}pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CWD
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BU of 9cwd by Molmil
Structure of human endothelial nitric oxide synthase heme domain bound with 6-(5-((dimethylamino)methyl)-2,3-difluorophenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{5-[(dimethylamino)methyl]-2,3-difluorophenyl}-4-methylpyridin-2-amine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CW8
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BU of 9cw8 by Molmil
Structure of human endothelial nitric oxide synthase heme domain bound with 3-(6-amino-4-methylpyridin-2-yl)-5-((methylamino)methyl)benzonitrile dihydrochloride
Descriptor: (3P)-3-(6-amino-4-methylpyridin-2-yl)-5-[(methylamino)methyl]benzonitrile, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVK
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BU of 9cvk by Molmil
Structure of rat neuronal nitric oxide synthase R349A mutant heme domain bound with 6-(3-chloro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6P)-6-{3-chloro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVV
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BU of 9cvv by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 6-(3-fluoro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{3-fluoro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CWK
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BU of 9cwk by Molmil
Structure of human endothelial nitric oxide synthase heme domain bound with 6-(2,3-difluoro-5-(2-(methylamino)ethyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{2,3-difluoro-5-[2-(methylamino)ethyl]phenyl}-4-methylpyridin-2-amine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVN
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BU of 9cvn by Molmil
Structure of rat neuronal nitric oxide synthase bound with 6-(2,3-difluoro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{2,3-difluoro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CVY
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BU of 9cvy by Molmil
Structure of human neuronal nitric oxide synthase R354A/G357D mutant heme domain bound with 6-(2,3-difluoro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{2,3-difluoro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, GLYCEROL, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (2.391 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025
9CW9
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BU of 9cw9 by Molmil
Structure of human endothelial nitric oxide synthase heme domain bound with 6-(2,3-difluoro-5-((methylamino)methyl)phenyl)-4-methylpyridin-2-amine dihydrochloride
Descriptor: (6M)-6-{2,3-difluoro-5-[(methylamino)methyl]phenyl}-4-methylpyridin-2-amine, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H, Poulos, T.L.
Deposit date:2024-07-29
Release date:2025-04-30
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Truncated pyridinylbenzylamines: Potent, selective, and highly membrane permeable inhibitors of human neuronal nitric oxide synthase.
Bioorg.Med.Chem., 124, 2025

238582

数据于2025-07-09公开中

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