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E. coli 50S ribosome bound to compound 47
Descriptor:	(3R,4R,5E,10E,12E,14S,16R,26aR)-16-fluoro-14-hydroxy-12-methyl-3-(propan-2-yl)-4-(prop-2-en-1-yl)-3,4,8,9,14,15,16,17,24,25,26,26a-dodecahydro-1H,7H,22H-21,18-(azeno)pyrrolo[2,1-c][1,8,4,19]dioxadiazacyclotetracosine-1,7,22-trione, 23S ribosomal RNA, 50S ribosomal protein L13, ...
Authors:	Pellegrino, J, Lee, D.J, Fraser, J.S, Seiple, I.B.
Deposit date:	2019-06-16
Release date:	2020-06-17
Last modified:	2020-10-07
Method:	ELECTRON MICROSCOPY (2.5 Å)
Cite:	Synthetic group A streptogramin antibiotics that overcome Vat resistance. Nature, 586, 2020

Crystal structure of Syk in complex with GS-9876
Descriptor:	6-(6-aminopyrazin-2-yl)-N-{4-[4-(oxetan-3-yl)piperazin-1-yl]phenyl}imidazo[1,2-a]pyrazin-8-amine, Tyrosine-protein kinase SYK
Authors:	Lansdon, E.B.
Deposit date:	2020-01-31
Release date:	2020-03-11
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Discovery of Lanraplenib (GS-9876): A Once-Daily Spleen Tyrosine Kinase Inhibitor for Autoimmune Diseases. Acs Med.Chem.Lett., 11, 2020