5WOD
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5WLJ
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5WLM
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1QP6
| SOLUTION STRUCTURE OF ALPHA2D | Descriptor: | PROTEIN (ALPHA2D) | Authors: | Hill, R.B, DeGrado, W.F. | Deposit date: | 1999-06-01 | Release date: | 1999-06-09 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of Alpha2D, A Nativelike De Novo Designed Protein J.Am.Chem.Soc., 120, 1998
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3LBW
| High resolution crystal structure of transmembrane domain of M2 | Descriptor: | 4-bromobenzoic acid, DI(HYDROXYETHYL)ETHER, M2 protein, ... | Authors: | Acharya, R, Polishchuk, A.L, DeGrado, W.F. | Deposit date: | 2010-01-08 | Release date: | 2010-07-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus. Proc.Natl.Acad.Sci.USA, 107, 2010
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5JOO
| XFEL structure of influenza A M2 wild type TM domain at low pH in the lipidic cubic phase at room temperature | Descriptor: | CALCIUM ION, CHLORIDE ION, Matrix protein 2 | Authors: | Thomaston, J.L, Woldeyes, R.A, Fraser, J.S, DeGrado, W.F. | Deposit date: | 2016-05-02 | Release date: | 2017-08-02 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.413 Å) | Cite: | XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5ET3
| Crystal Structure of De novo Designed Fullerene organizing peptide | Descriptor: | (C_{60}-I_{h})[5,6]fullerene, Fullerene Organizing Protein (C60Sol-COP-3) | Authors: | Kim, K.-H, Kim, Y.H, Acharya, R, Kim, N.H, Paul, J, Grigoryan, G, DeGrado, W.F. | Deposit date: | 2015-11-17 | Release date: | 2016-05-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.671 Å) | Cite: | Protein-directed self-assembly of a fullerene crystal. Nat Commun, 7, 2016
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1YOD
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1Y47
| Structural studies of designed alpha-helical hairpins | Descriptor: | CADMIUM ION, dueferri (DF2) | Authors: | Lahr, S.J, Engel, D.E, Stayrook, S.E, Maglio, O, North, B, Geremia, S, Lombardi, A, DeGrado, W.F. | Deposit date: | 2004-11-30 | Release date: | 2005-03-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Analysis and design of turns in alpha-helical hairpins J.Mol.Biol., 346, 2005
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2A3D
| SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D) | Descriptor: | PROTEIN (DE NOVO THREE-HELIX BUNDLE) | Authors: | Walsh, S.T.R, Cheng, H, Bryson, J.W, Roder, H, Degrado, W.F. | Deposit date: | 1999-04-01 | Release date: | 1999-05-05 | Last modified: | 2023-12-27 | Method: | SOLUTION NMR | Cite: | Solution structure and dynamics of a de novo designed three-helix bundle protein. Proc.Natl.Acad.Sci.USA, 96, 1999
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6US9
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6US8
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6YB1
| Crystal structure of an antiparallel octameric transmembrane coiled coil K2-CCTM-VbIc | Descriptor: | GLYCINE, K2-CCTM-VbIc, NONAETHYLENE GLYCOL | Authors: | Kratochvil, H.T, Liu, L, Scott, A.J, Woolfson, D.N, DeGrado, W.F. | Deposit date: | 2020-03-15 | Release date: | 2021-04-07 | Last modified: | 2021-07-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Constructing ion channels from water-soluble alpha-helical barrels. Nat.Chem., 13, 2021
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6Z0L
| Het-N2 - De novo designed three-helix heterodimer with Cysteine at the N2 position of the alpha-helix | Descriptor: | CADMIUM ION, Cys-N2 Strand, Positive Strand, ... | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. | Deposit date: | 2020-05-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
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6Z0M
| Het-Ncap - De novo designed three-helix heterodimer with Cysteine at the Ncap position of the alpha-helix | Descriptor: | Cys-Ncap strand, Positive Strand, SULFATE ION, ... | Authors: | McEwen, A.G, Poussin-Courmontagne, P, Naudin, E.A, DeGrado, W.F, Torbeev, V. | Deposit date: | 2020-05-09 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Acyl Transfer Catalytic Activity in De Novo Designed Protein with N-Terminus of alpha-Helix As Oxyanion-Binding Site. J.Am.Chem.Soc., 143, 2021
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2MUZ
| ssNMR structure of a designed rocker protein | Descriptor: | designed rocker protein | Authors: | Wang, T, Joh, N, Wu, Y, DeGrado, W.F, Hong, M. | Deposit date: | 2014-09-18 | Release date: | 2014-12-24 | Last modified: | 2015-01-14 | Method: | SOLUTION NMR | Cite: | De novo design of a transmembrane Zn2+-transporting four-helix bundle. Science, 346, 2014
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2KQT
| Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine | Descriptor: | (3S,5S,7S)-tricyclo[3.3.1.1~3,7~]decan-1-amine, M2 protein | Authors: | Cady, S.D, Schmidt-Rohr, K, Wang, J, Soto, C.S, DeGrado, W.F, Hong, M. | Deposit date: | 2009-11-18 | Release date: | 2010-02-09 | Last modified: | 2024-05-08 | Method: | SOLID-STATE NMR | Cite: | Structure of the amantadine binding site of influenza M2 proton channels in lipid bilayers Nature, 463, 2010
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4P6J
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4P6K
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1AL1
| CRYSTAL STRUCTURE OF ALPHA1: IMPLICATIONS FOR PROTEIN DESIGN | Descriptor: | ALPHA HELIX PEPTIDE: ELLKKLLEELKG, SULFATE ION | Authors: | Hill, C.P, Anderson, D.H, Wesson, L, Degrado, W.F, Eisenberg, D. | Deposit date: | 1990-07-02 | Release date: | 1991-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of alpha 1: implications for protein design. Science, 249, 1990
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1COI
| DESIGNED TRIMERIC COILED COIL-VALD | Descriptor: | COIL-VALD, SULFATE ION | Authors: | Ogihara, N.L, Weiss, M.S, Degrado, W.F, Eisenberg, D. | Deposit date: | 1996-08-10 | Release date: | 1997-02-12 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of the designed trimeric coiled coil coil-VaLd: implications for engineering crystals and supramolecular assemblies. Protein Sci., 6, 1997
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4QKC
| Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under cryo diffraction conditions | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2014-06-05 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proc.Natl.Acad.Sci.USA, 112, 2015
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4QKM
| Influenza A M2 wild type TM domain at low pH in the lipidic cubic phase under room temperature diffraction conditions | Descriptor: | (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1,2-ETHANEDIOL, CALCIUM ION, ... | Authors: | Thomaston, J.L, DeGrado, W.F. | Deposit date: | 2014-06-06 | Release date: | 2015-11-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.44 Å) | Cite: | High-resolution structures of the M2 channel from influenza A virus reveal dynamic pathways for proton stabilization and transduction. Proc.Natl.Acad.Sci.USA, 112, 2015
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4QKL
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6MJH
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