6POD
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 2 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.05 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PP5
| ClpX in ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.98 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PPE
| ClpP and ClpX IGF loop in ClpX-ClpP complex with D7 symmetry | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-06 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PO3
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6POS
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PP6
| ClpX in ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 3 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PO1
| ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 4 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-03 | Release date: | 2020-03-11 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PP8
| ClpX in ClpX-ClpP complex bound to substrate and ATP-gamma-S, class 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Fei, X, Jenni, S, Harrison, S.C, Sauer, R.T. | Deposit date: | 2019-07-05 | Release date: | 2020-03-11 | Method: | ELECTRON MICROSCOPY (4.12 Å) | Cite: | Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate. Elife, 9, 2020
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6PXI
| The crystal structure of a singly capped HslUV complex with an axial pore plug and a HslU E257Q mutation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent protease ATPase subunit HslU, ATP-dependent protease subunit HslV, ... | Authors: | Baytshtok, V, Grant, R.A, Sauer, R.T. | Deposit date: | 2019-07-26 | Release date: | 2020-07-29 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (3.447 Å) | Cite: | Heat activates the AAA+ HslUV protease by melting an axial autoinhibitory plug. Cell Rep, 34, 2021
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2HDD
| ENGRAILED HOMEODOMAIN Q50K VARIANT DNA COMPLEX | Descriptor: | DNA (5'-D(*AP*TP*CP*CP*GP*GP*GP*GP*AP*TP*TP*AP*CP*AP*TP*GP*G P*CP*AP*AP*A)-3'), DNA (5'-D(*TP*TP*TP*TP*GP*CP*CP*AP*TP*GP*TP*AP*AP*TP*CP*CP*C P*CP*GP*GP*A)-3'), PROTEIN (ENGRAILED HOMEODOMAIN Q50K) | Authors: | Tucker-Kellogg, L, Rould, M.A, Chambers, K.A, Ades, S.E, Sauer, R.T, Pabo, C.O. | Deposit date: | 1998-02-10 | Release date: | 1998-05-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Engrailed (Gln50-->Lys) homeodomain-DNA complex at 1.9 A resolution: structural basis for enhanced affinity and altered specificity. Structure, 5, 1997
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3O1F
| P1 crystal form of E. coli ClpS at 1.4 A resolution | Descriptor: | ATP-dependent Clp protease adapter protein clpS | Authors: | Roman-Hernandez, G, Hou, J.Y, Grant, R.A, Sauer, R.T, Baker, T.A. | Deposit date: | 2010-07-21 | Release date: | 2011-07-27 | Last modified: | 2017-11-08 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | The ClpS Adaptor Mediates Staged Delivery of N-End Rule Substrates to the AAA+ ClpAP Protease. Mol.Cell, 43, 2011
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3O2B
| E. coli ClpS in complex with a Phe N-end rule peptide | Descriptor: | ATP-dependent Clp protease adaptor protein ClpS, CHLORIDE ION, Phe N-end rule peptide, ... | Authors: | Roman-Hernandez, G, Grant, R.A, Sauer, R.T, Baker, T.A, de Regt, A. | Deposit date: | 2010-07-22 | Release date: | 2011-12-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol.Cell, 43, 2011
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3O2H
| E. coli ClpS in complex with a Leu N-end rule peptide | Descriptor: | ATP-dependent Clp protease adaptor protein ClpS, DNA protection during starvation protein | Authors: | Roman-Hernandez, G, Grant, R.A, Sauer, R.T, Baker, T.A, de Regt, A. | Deposit date: | 2010-07-22 | Release date: | 2011-12-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol.Cell, 43, 2011
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3O2O
| Structure of E. coli ClpS ring complex | Descriptor: | ATP-dependent Clp protease adaptor protein ClpS | Authors: | Roman-Hernandez, G, Grant, R.A, Sauer, R.T, Baker, T.A, de Regt, A. | Deposit date: | 2010-07-22 | Release date: | 2011-12-14 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The ClpS adaptor mediates staged delivery of N-end rule substrates to the AAA+ ClpAP protease. Mol.Cell, 43, 2011
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3OTP
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8E91
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8E8Q
| Cryo-EM structure of substrate-free DNClpX.ClpP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ghanbarpour, A, Cohen, S, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-08-25 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structure of substrate-free DNClpX.ClpP Nat Commun, 2023
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8E7V
| Cryo-EM structure of substrate-free DNClpX.ClpP from singly capped particles | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | Authors: | Ghanbarpour, A, Cohen, S, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-08-24 | Release date: | 2023-11-08 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Cryo-EM structure of substrate-free DNClpX.ClpP Nat Commun, 2023
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8ET3
| Cryo-EM structure of a delivery complex containing the SspB adaptor, an ssrA-tagged substrate, and the AAA+ ClpXP protease | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ATP-dependent Clp protease proteolytic subunit, ... | Authors: | Ghanbarpour, A, Fei, X, Davis, J.H, Sauer, R.T. | Deposit date: | 2022-10-16 | Release date: | 2023-01-25 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | The SspB adaptor drives structural changes in the AAA+ ClpXP protease during ssrA-tagged substrate delivery. Proc.Natl.Acad.Sci.USA, 120, 2023
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4I63
| Crystal Structure of E-R ClpX Hexamer | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, SULFATE ION | Authors: | Glynn, S.E, Nager, A.R, Stinson, B.S, Schmitz, K.R, Baker, T.A, Sauer, R.T. | Deposit date: | 2012-11-29 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (5.709 Å) | Cite: | Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell(Cambridge,Mass.), 153, 2013
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4I81
| Crystal Structure of ATPgS bound ClpX Hexamer | Descriptor: | ATP-dependent Clp protease ATP-binding subunit ClpX, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, SULFATE ION | Authors: | Glynn, S.E, Nager, A.R, Stinson, B.S, Schmitz, K.R, Baker, T.A, Sauer, R.T. | Deposit date: | 2012-12-01 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.8182 Å) | Cite: | Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell(Cambridge,Mass.), 153, 2013
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4I4L
| Crystal Structure of Nucleotide-Bound W-W-W ClpX Hexamer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, SULFATE ION | Authors: | Glynn, S.E, Nager, A.R, Stinson, B.S, Schmitz, K.R, Baker, T.A, Sauer, R.T. | Deposit date: | 2012-11-27 | Release date: | 2013-05-15 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.6981 Å) | Cite: | Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine. Cell(Cambridge,Mass.), 153, 2013
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3LH1
| Q191A mutant of the DegS-deltaPDZ | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.507 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3LGU
| Y162A mutant of the DegS-deltaPDZ protease | Descriptor: | Protease degS | Authors: | Sohn, J, Grant, R.A, Sauer, R.T. | Deposit date: | 2010-01-21 | Release date: | 2010-08-25 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution. J.Biol.Chem., 285, 2010
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3HTE
| Crystal structure of nucleotide-free hexameric ClpX | Descriptor: | ATP-dependent Clp protease ATP-binding subunit clpX, SULFATE ION | Authors: | Glynn, S.E, Martin, A, Baker, T.A, Sauer, R.T. | Deposit date: | 2009-06-11 | Release date: | 2009-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (4.026 Å) | Cite: | Structures of asymmetric ClpX hexamers reveal nucleotide-dependent motions in a AAA+ protein-unfolding machine. Cell(Cambridge,Mass.), 139, 2009
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