165L
| CONTROL OF ENZYME ACTIVITY BY AN ENGINEERED DISULFIDE BOND | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, T4 LYSOZYME | Authors: | Blaber, M, Matthews, B.W. | Deposit date: | 1994-06-20 | Release date: | 1994-08-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Alanine scanning mutagenesis of the alpha-helix 115-123 of phage T4 lysozyme: effects on structure, stability and the binding of solvent. J.Mol.Biol., 246, 1995
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172L
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153L
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178L
| Protein flexibility and adaptability seen in 25 crystal forms of T4 LYSOZYME | Descriptor: | CHLORIDE ION, T4 LYSOZYME | Authors: | Matsumura, M, Weaver, L, Zhang, X.-J, Matthews, B.W. | Deposit date: | 1995-03-24 | Release date: | 1995-07-10 | Last modified: | 2021-11-03 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. J.Mol.Biol., 250, 1995
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2B3K
| Crystal structure of Human Methionine Aminopeptidase Type I in the holo form | Descriptor: | ACETATE ION, COBALT (II) ION, GLYCEROL, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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2B3L
| Crystal structure of type I human methionine aminopeptidase in the apo form | Descriptor: | ACETIC ACID, GLYCEROL, Methionine aminopeptidase 1, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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2B70
| T4 Lysozyme mutant L99A at ambient pressure | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M, TB Structural Genomics Consortium (TBSGC) | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B3H
| Crystal structure of Human Methionine Aminopeptidase Type I with a third cobalt in the active site | Descriptor: | CHLORIDE ION, COBALT (II) ION, GLYCEROL, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2005-09-20 | Release date: | 2005-11-22 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structural Basis for the Functional Differences between Type I and Type II Human Methionine Aminopeptidases(,). Biochemistry, 44, 2005
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2B6W
| T4 Lysozyme mutant L99A at 200 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B72
| T4 Lysozyme mutant L99A at 100 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6Z
| T4 Lysozyme mutant L99A at ambient pressure | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B75
| T4 Lysozyme mutant L99A at 150 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6Y
| T4 Lysozyme mutant L99A at ambient pressure | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6X
| T4 Lysozyme mutant L99A at 200 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.107 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B73
| T4 Lysozyme mutant L99A at 100 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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2B6T
| T4 Lysozyme mutant L99A at 200 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural rigidity of a large cavity-containing protein revealed by high-pressure crystallography. J.Mol.Biol., 367, 2007
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2B74
| T4 Lysozyme mutant L99A at 100 MPa | Descriptor: | BETA-MERCAPTOETHANOL, CHLORIDE ION, Lysozyme | Authors: | Collins, M.D, Quillin, M.L, Matthews, B.W, Gruner, S.M. | Deposit date: | 2005-10-03 | Release date: | 2005-11-08 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Cooperative water filling of a nonpolar protein cavity observed by high-pressure crystallography and simulation Proc.Natl.Acad.Sci.Usa, 102, 2005
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1BIB
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1BIA
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2EWN
| Ecoli Biotin Repressor with co-repressor analog | Descriptor: | ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXY-TETRAHYDROFURAN-2-YL)METHYL 5-((3AS,4S,6AR)-2-OXO-HEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL)PENTYL HYDROGEN PHOSPHATE, BirA bifunctional protein | Authors: | Wood, Z.A, Weaver, L.H, Matthews, B.W. | Deposit date: | 2005-11-04 | Release date: | 2006-02-21 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Co-repressor Induced Order and Biotin Repressor Dimerization: A Case for Divergent Followed by Convergent Evolution. J.Mol.Biol., 357, 2006
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2G6P
| Crystal structure of truncated (delta 1-89) human methionine aminopeptidase Type 1 in complex with Pyridyl pyrimidine derivative | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 5-CHLORO-6-METHYL-N-(2-PHENYLETHYL)-2-PYRIDIN-2-YLPYRIMIDIN-4-AMINE, COBALT (II) ION, ... | Authors: | Addlagatta, A, Hu, X, Liu, J.O, Matthews, B.W. | Deposit date: | 2006-02-24 | Release date: | 2006-06-20 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification of Pyridinylpyrimidines as Inhibitors of Human Methionine Aminopeptidases. Angew.Chem.Int.Ed.Engl., 45, 2006
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1JTN
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1JTM
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1KW7
| METHIONINE CORE MUTANT OF T4 LYSOZYME | Descriptor: | 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME | Authors: | Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. | Deposit date: | 2002-01-28 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
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1KS3
| METHIONINE CORE MUTANT OF T4 LYSOZYME | Descriptor: | 2-HYDROXYETHYL DISULFIDE, CHLORIDE ION, LYSOZYME | Authors: | Gassner, N.C, Baase, W.A, Mooers, B.H, Busam, R.D, Weaver, L.H, Lindstrom, J.D, Quillin, M.L, Matthews, B.W. | Deposit date: | 2002-01-10 | Release date: | 2003-06-03 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Multiple methionine substitutions are tolerated in T4 lysozyme and have coupled effects on folding and stability BIOPHYS.CHEM., 100, 2003
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