8HZ4
 
 | |
8IQY
 | |
8IQV
 | |
8IQW
 | |
8IQZ
 | |
6IUP
 | | Crystal structure of FGFR4 kinase domain in complex with compound 5 | | Descriptor: | DIMETHYL SULFOXIDE, Fibroblast growth factor receptor 4, N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide | | Authors: | Xu, Y, Liu, Q. | | Deposit date: | 2018-11-29 | | Release date: | 2019-11-06 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
|
|
6IUO
 | | Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor | | Descriptor: | Fibroblast growth factor receptor 4, N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide | | Authors: | Xu, Y, Liu, Q. | | Deposit date: | 2018-11-29 | | Release date: | 2019-10-23 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
|
|
6ITJ
 | | Crystal structure of FGFR1 kinase domain in complex with compound 3 | | Descriptor: | 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one, Fibroblast growth factor receptor 1 | | Authors: | Xu, Y, Liu, Q. | | Deposit date: | 2018-11-23 | | Release date: | 2019-10-23 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.994 Å) | | Cite: | Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
|
|
1T0Z
 | | Structure of an Excitatory Insect-specific Toxin with an Analgesic Effect on Mammalian from Scorpion Buthus martensii Karsch | | Descriptor: | SULFATE ION, insect neurotoxin | | Authors: | Li, C, Guan, R.-J, Xiang, Y, Zhang, Y, Wang, D.-C. | | Deposit date: | 2004-04-14 | | Release date: | 2004-12-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of an excitatory insect-specific toxin with an analgesic effect on mammals from the scorpion Buthus martensii Karsch.
Acta Crystallogr.,Sect.D, 61, 2005
|
|
8TLH
 | | CDCA7 (Mouse) Binds Non-B-form 32-mer DNA oligo | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (32-MER), ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Biorxiv, 2023
|
|
8TLF
 | | CDCA7 (Mouse) Binds Non-B-form DNA oligo 36-mer (sg C2-Form 2) | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, GLYCEROL, ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Biorxiv, 2023
|
|
8TLK
 | | CDCA7 (Human) Binds Non-B-form 32-mer DNA oligo Containing a 5mC | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (32-MER), ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Biorxiv, 2023
|
|
8TLL
 | | CDCA7 (Mouse) Binds Non-B-form 26-mer DNA oligo | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (26-MER), ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Sci Adv, 10, 2024
|
|
8TLJ
 | | CDCA7 (Mouse) Binds Non-B-form 32-mer DNA oligo Containing a 5mC | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (32-MER), ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Biorxiv, 2023
|
|
8TLE
 | |
8TLG
 | | CDCA7 (Mouse) Binds Non-B-form 34-mer DNA oligo | | Descriptor: | 1,2-ETHANEDIOL, Cell division cycle-associated protein 7, DNA (34-MER), ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2023-07-26 | | Release date: | 2024-08-21 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA.
Biorxiv, 2023
|
|
7N0D
 | |
7N0B
 | | Cryo-EM structure of SARS-CoV-2 nsp10-nsp14 (WT)-RNA complex | | Descriptor: | CALCIUM ION, Non-structural protein 10, Proofreading exoribonuclease, ... | | Authors: | Liu, C, Yang, Y. | | Deposit date: | 2021-05-25 | | Release date: | 2021-07-28 | | Last modified: | 2025-05-28 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural basis of mismatch recognition by a SARS-CoV-2 proofreading enzyme.
Science, 373, 2021
|
|
7N0C
 | |
2LMC
 | |
2NO3
 | | Novel 4-anilinopyrimidines as potent JNK1 Inhibitors | | Descriptor: | 2-({2-[(3-HYDROXYPHENYL)AMINO]PYRIMIDIN-4-YL}AMINO)BENZAMIDE, C-JUN-AMINO-TERMINAL KINASE-INTERACTING protein 1, Mitogen-activated protein kinase 8, ... | | Authors: | Abad-Zapatero, C. | | Deposit date: | 2006-10-24 | | Release date: | 2007-04-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Discovery of a new class of 4-anilinopyrimidines as potent c-Jun N-terminal kinase inhibitors: Synthesis and SAR studies.
Bioorg.Med.Chem.Lett., 17, 2007
|
|
1VWC
 | | STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 2.0 | | Descriptor: | PEPTIDE LIGAND CONTAINING HPQ, STREPTAVIDIN | | Authors: | Katz, B.A, Cass, R.T. | | Deposit date: | 1997-03-03 | | Release date: | 1998-03-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
|
|
1VWB
 | | STREPTAVIDIN-CYCLO-AC-[CHPQFC]-NH2, PH 11.8 | | Descriptor: | PEPTIDE LIGAND CONTAINING HPQ, STREPTAVIDIN | | Authors: | Katz, B.A, Cass, R.T. | | Deposit date: | 1997-03-03 | | Release date: | 1998-03-18 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0.
J.Biol.Chem., 272, 1997
|
|
1VWG
 | |
1VWR
 | |
