6Z2I
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![BU of 6z2i by Molmil](/molmil-images/mine/6z2i) | Crystal structure of DeNovoTIM6, a de novo designed TIM barrel | Descriptor: | de novo designed TIM barrel DeNovoTIM6 | Authors: | Romero-Romero, S, Kordes, S, Shanmugaratnam, S, Rodriguez-Romero, A, Fernandez-Velasco, D.A, Hocker, B. | Deposit date: | 2020-05-15 | Release date: | 2021-07-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach. J.Mol.Biol., 433, 2021
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6YQY
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![BU of 6yqy by Molmil](/molmil-images/mine/6yqy) | Crystal structure of sTIM11noCys, a de novo designed TIM barrel | Descriptor: | de novo designed TIM barrel sTIM11noCys | Authors: | Romero-Romero, S, Wiese, G.J, Kordes, S, Shanmugaratnam, S, Fernandez-Velasco, D.A, Hocker, B. | Deposit date: | 2020-04-18 | Release date: | 2021-07-21 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.876 Å) | Cite: | The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach. J.Mol.Biol., 433, 2021
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6YQX
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![BU of 6yqx by Molmil](/molmil-images/mine/6yqx) | Crystal structure of DeNovoTIM13, a de novo designed TIM barrel | Descriptor: | CHLORIDE ION, GLYCEROL, de novo designed TIM barrel DeNovoTIM13 | Authors: | Romero-Romero, S, Kordes, S, Shanmugaratnam, S, Fernandez-Velasco, D.A, Hocker, B. | Deposit date: | 2020-04-18 | Release date: | 2021-07-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.638 Å) | Cite: | The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach. J.Mol.Biol., 433, 2021
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6CG9
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![BU of 6cg9 by Molmil](/molmil-images/mine/6cg9) | Crystal structure of Triosephosphate Isomerase from Zea mays (mexican corn) | Descriptor: | ACETATE ION, GLYCEROL, Triosephosphate isomerase, ... | Authors: | Romero-Romero, S, Fernandez-Velasco, D.A, Rodriguez-Romero, A. | Deposit date: | 2018-02-19 | Release date: | 2018-10-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and conformational stability of the triosephosphate isomerase from Zea mays. Comparison with the chemical unfolding pathways of other eukaryotic TIMs. Arch. Biochem. Biophys., 658, 2018
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7PEK
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![BU of 7pek by Molmil](/molmil-images/mine/7pek) | |
7PEJ
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![BU of 7pej by Molmil](/molmil-images/mine/7pej) | |
4Y90
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![BU of 4y90 by Molmil](/molmil-images/mine/4y90) | Crystal structure of Triosephosphate Isomerase from Deinococcus radiodurans | Descriptor: | CALCIUM ION, GLYCEROL, SODIUM ION, ... | Authors: | Romero-Romero, S, Rodriguez-Romero, A, Fernadez-Velasco, D.A. | Deposit date: | 2015-02-16 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
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4Y9A
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![BU of 4y9a by Molmil](/molmil-images/mine/4y9a) | |
4Y8F
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![BU of 4y8f by Molmil](/molmil-images/mine/4y8f) | |
4Y96
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![BU of 4y96 by Molmil](/molmil-images/mine/4y96) | Crystal structure of Triosephosphate Isomerase from Gemmata obscuriglobus | Descriptor: | CALCIUM ION, PHOSPHATE ION, SODIUM ION, ... | Authors: | Romero-Romero, S, Rodriguez-Romero, A, Fernandez-Velasco, D.A. | Deposit date: | 2015-02-17 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.581 Å) | Cite: | Reversibility and two state behaviour in the thermal unfolding of oligomeric TIM barrel proteins. Phys Chem Chem Phys, 17, 2015
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6XKS
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![BU of 6xks by Molmil](/molmil-images/mine/6xks) | Crystal structure of domain A from the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) of Salmonella typhimurium | Descriptor: | ACETATE ION, DI(HYDROXYETHYL)ETHER, Histidine ABC transporter substrate-binding protein HisJ | Authors: | Romero-Romero, S, Berrocal, T, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2020-06-27 | Release date: | 2021-07-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Thermodynamic and kinetic analysis of the LAO binding protein and its isolated domains reveal non-additivity in stability, folding and function. Febs J., 2023
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7OSU
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![BU of 7osu by Molmil](/molmil-images/mine/7osu) | sTIM11noCys-SB, a de novo designed TIM barrel with a salt-bridge cluster (crystal form 1) | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | Authors: | Romero-Romero, S, Kordes, S, Hocker, B. | Deposit date: | 2021-06-09 | Release date: | 2021-12-15 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels. Protein Sci., 31, 2022
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7OT7
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![BU of 7ot7 by Molmil](/molmil-images/mine/7ot7) | |
7PU4
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![BU of 7pu4 by Molmil](/molmil-images/mine/7pu4) | |
6MLJ
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![BU of 6mlj by Molmil](/molmil-images/mine/6mlj) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) S70A mutant from Salmonella typhimurium complexed with arginine | Descriptor: | ACETATE ION, ARGININE, Lysine/arginine/ornithine transport protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLV
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![BU of 6mlv by Molmil](/molmil-images/mine/6mlv) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) Y14A mutant from Salmonella typhimurium | Descriptor: | Lysine/arginine/ornithine-binding periplasmic protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-28 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.082 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6ML0
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![BU of 6ml0 by Molmil](/molmil-images/mine/6ml0) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) S69A mutant from Salmonella typhimurium | Descriptor: | ACETATE ION, GLYCEROL, Lysine/arginine/ornithine-binding periplasmic protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-26 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLO
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![BU of 6mlo by Molmil](/molmil-images/mine/6mlo) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) Y14A mutant from Salmonella typhimurium complexed with arginine | Descriptor: | ACETATE ION, ARGININE, GLYCEROL, ... | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.717 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLI
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![BU of 6mli by Molmil](/molmil-images/mine/6mli) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) R77A mutant from Salmonella typhimurium complexed with histidine | Descriptor: | ACETATE ION, GLYCEROL, HISTIDINE, ... | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.883 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MKX
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![BU of 6mkx by Molmil](/molmil-images/mine/6mkx) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) R77A mutant from Salmonella typhimurium | Descriptor: | Lysine/arginine/ornithine-binding periplasmic protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-26 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.284 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLE
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![BU of 6mle by Molmil](/molmil-images/mine/6mle) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) from Salmonella typhimurium complexed with arginine | Descriptor: | ACETATE ION, ARGININE, Lysine/arginine/ornithine-binding periplasmic protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.858 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLG
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![BU of 6mlg by Molmil](/molmil-images/mine/6mlg) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) R77A mutant from Salmonella typhimurium complexed with arginine | Descriptor: | ACETATE ION, ARGININE, Lysine/arginine/ornithine-binding periplasmic protein, ... | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.892 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MKW
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![BU of 6mkw by Molmil](/molmil-images/mine/6mkw) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) D11A mutant from Salmonella typhimurium complexed with histidine | Descriptor: | GLYCEROL, HISTIDINE, Lysine/arginine/ornithine transport protein | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-26 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLP
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![BU of 6mlp by Molmil](/molmil-images/mine/6mlp) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) Y14A mutant from Salmonella typhimurium complexed with histidine | Descriptor: | ACETATE ION, GLYCEROL, HISTIDINE, ... | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.485 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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6MLA
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![BU of 6mla by Molmil](/molmil-images/mine/6mla) | Crystal structure of the periplasmic Lysine-, Arginine-, Ornithine-binding protein (LAO) D161A mutant from Salmonella typhimurium complexed with arginine | Descriptor: | ACETATE ION, ARGININE, GLYCEROL, ... | Authors: | Romero-Romero, S, Vergara, R, Espinoza-Perez, G, Rodriguez-Romero, A. | Deposit date: | 2018-09-27 | Release date: | 2019-08-07 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.582 Å) | Cite: | The interplay of protein-ligand and water-mediated interactions shape affinity and selectivity in the LAO binding protein. Febs J., 287, 2020
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