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Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A
Descriptor:	Nuclear receptor corepressor 1, Rev-erbA-alpha
Authors:	Gampe, R, Nolte, R.
Deposit date:	2010-05-13
Release date:	2010-06-30
Last modified:	2023-09-06
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. Nat.Struct.Mol.Biol., 17, 2010

Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase
Descriptor:	(2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase
Authors:	Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D.
Deposit date:	2016-01-19
Release date:	2016-12-14
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (4.4 Å)
Cite:	Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016

Crystal structure of PDE3B in complex with GSK4394835A
Descriptor:	MAGNESIUM ION, [3-[(4,7-dimethoxyquinolin-2-yl)carbonylamino]-5-[methyl-(phenylmethyl)carbamoyl]phenyl]-oxidanyl-oxidanylidene-boron, cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B
Authors:	Concha, N.O, Nolte, R.
Deposit date:	2023-05-25
Release date:	2024-02-07
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Discovery and SAR Study of Boronic Acid-Based Selective PDE3B Inhibitors from a Novel DNA-Encoded Library. J.Med.Chem., 67, 2024