9END
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 9end by Molmil](/molmil-images/mine/9end) | Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 3 | Descriptor: | CHLORIDE ION, Malate dehydrogenase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Coquille, S, Roche, J, Girard, E, Madern, D. | Deposit date: | 2024-03-12 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme. To be published
|
|
8RS5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rs5 by Molmil](/molmil-images/mine/8rs5) | |
8RWL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8rwl by Molmil](/molmil-images/mine/8rwl) | Crystal structure of Methanopyrus kandleri malate dehydrogenase mutant 1 | Descriptor: | CHLORIDE ION, GLYCEROL, Malate dehydrogenase, ... | Authors: | Coquille, S, Roche, J, Engilberge, S, Girard, E, Madern, D. | Deposit date: | 2024-02-05 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Navigating the conformational landscape of an enzyme. Stabilization of a low populated conformer by evolutionary mutations triggers Allostery into a non-allosteric enzyme. To Be Published
|
|
8Q3C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8q3c by Molmil](/molmil-images/mine/8q3c) | Structure of Selenomonas ruminantium lactate dehydrogenase I85R mutant | Descriptor: | CHLORIDE ION, L-lactate dehydrogenase, NITRATE ION, ... | Authors: | Bertrand, Q, Coquille, S, Iorio, A, Sterpone, F, Madern, D. | Deposit date: | 2023-08-03 | Release date: | 2023-11-01 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
|
|
4WN4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wn4 by Molmil](/molmil-images/mine/4wn4) | Crystal structure of designed cPPR-polyA protein | Descriptor: | Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-10-10 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.85 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
|
|
4WSL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4wsl by Molmil](/molmil-images/mine/4wsl) | Crystal structure of designed cPPR-polyC protein | Descriptor: | Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-10-28 | Release date: | 2014-12-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
|
|
4H67
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h67 by Molmil](/molmil-images/mine/4h67) | Crystal structure of HMP synthase Thi5 from S. cerevisiae | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Pyrimidine precursor biosynthesis enzyme THI5, SULFATE ION | Authors: | Coquille, S.C, Roux, C, Fitzpatrick, T, Thore, S. | Deposit date: | 2012-09-19 | Release date: | 2012-10-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Last Piece in the Vitamin B1 Biosynthesis Puzzle: STRUCTURAL AND FUNCTIONAL INSIGHT INTO YEAST 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE (HMP-P) SYNTHASE. J.Biol.Chem., 287, 2012
|
|
4H6D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h6d by Molmil](/molmil-images/mine/4h6d) | Crystal structure of PLP-soaked HMP synthase Thi5 from S. cerevisiae | Descriptor: | PYRIDOXAL-5'-PHOSPHATE, Pyrimidine precursor biosynthesis enzyme THI5 | Authors: | Coquille, S.C, Roux, C, Fitzpatrick, T, Thore, S. | Deposit date: | 2012-09-19 | Release date: | 2012-10-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The Last Piece in the Vitamin B1 Biosynthesis Puzzle: STRUCTURAL AND FUNCTIONAL INSIGHT INTO YEAST 4-AMINO-5-HYDROXYMETHYL-2-METHYLPYRIMIDINE PHOSPHATE (HMP-P) SYNTHASE. J.Biol.Chem., 287, 2012
|
|
4H65
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4h65 by Molmil](/molmil-images/mine/4h65) | |
4PJS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pjs by Molmil](/molmil-images/mine/4pjs) | Crystal structure of designed (SeMet)-cPPR-NRE protein | Descriptor: | CALCIUM ION, Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-05-12 | Release date: | 2014-12-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
|
|
4PJQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pjq by Molmil](/molmil-images/mine/4pjq) | Crystal structure of designed cPPR-polyG protein | Descriptor: | Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-05-12 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.353 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
|
|
4N7Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4n7q by Molmil](/molmil-images/mine/4n7q) | Crystal structure of eukaryotic THIC from A. thaliana | Descriptor: | COBALT (II) ION, HEXANE-1,6-DIOL, Phosphomethylpyrimidine synthase, ... | Authors: | Coquille, S.C, Roux, C, Mehta, A, Begley, T.P, Fitzpatrick, T.B, Thore, S. | Deposit date: | 2013-10-16 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | High-resolution crystal structure of the eukaryotic HMP-P synthase (THIC) from Arabidopsis thaliana. J.Struct.Biol., 184, 2013
|
|
4PJR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4pjr by Molmil](/molmil-images/mine/4pjr) | Crystal structure of designed cPPR-NRE protein | Descriptor: | MAGNESIUM ION, Pentatricopeptide repeat protein | Authors: | Coquille, S.C, Filipovska, A, Chia, T.S, Rajappa, L, Lingford, J.P, Razif, M.F.M, Thore, S, Rackham, O. | Deposit date: | 2014-05-12 | Release date: | 2014-12-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | An artificial PPR scaffold for programmable RNA recognition. Nat Commun, 5, 2014
|
|
7NAY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7nay by Molmil](/molmil-images/mine/7nay) | Crystal structure of lactate dehydrogenase from Selenomonas ruminantium with NADH. | Descriptor: | 1,2-ETHANEDIOL, BORIC ACID, L-lactate dehydrogenase, ... | Authors: | Bertrand, Q, Robin, A, Girard, E, Madern, D. | Deposit date: | 2021-01-25 | Release date: | 2021-02-10 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases. J.Struct.Biol., 215, 2023
|
|
8B75
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8b75 by Molmil](/molmil-images/mine/8b75) | CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLYL CYCLASE IN COMPLEX WITH THE INHIBITOR TDI-011861 | Descriptor: | Adenylate cyclase type 10, [(3~{R})-4-[2-[2-[[3-(2-azanyl-6-chloranyl-pyrimidin-4-yl)-1-[bis(fluoranyl)methyl]pyrazol-4-yl]methyl]phenoxy]ethyl]morpholin-3-yl]methanol | Authors: | Steegborn, C, Kehr, M. | Deposit date: | 2022-09-28 | Release date: | 2023-03-29 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Design, Synthesis, and Pharmacological Evaluation of Second-Generation Soluble Adenylyl Cyclase (sAC, ADCY10) Inhibitors with Slow Dissociation Rates. J.Med.Chem., 65, 2022
|
|