6C1S
 
 | | Phosphoinositide 3-Kinase gamma bound to an pyrrolopyridinone Inhibitor | | Descriptor: | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, {4-[2-(5,6-dimethoxypyridin-3-yl)-5-oxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyridin-6-yl]-1H-pyrazol-1-yl}acetonitrile | | Authors: | Jacobs, M.D, Griffin, J.P. | | Deposit date: | 2018-01-05 | | Release date: | 2018-06-27 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.31 Å) | | Cite: | Design and Synthesis of a Novel Series of Orally Bioavailable, CNS-Penetrant, Isoform Selective Phosphoinositide 3-Kinase gamma (PI3K gamma ) Inhibitors with Potential for the Treatment of Multiple Sclerosis (MS).
J. Med. Chem., 61, 2018
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8HJ1
 | | GPR21(wt) and Gs complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | Authors: | Chen, B, Lin, X, Xu, F. | | Deposit date: | 2022-11-22 | | Release date: | 2023-12-27 | | Method: | ELECTRON MICROSCOPY (3.27 Å) | | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes.
Nat Commun, 14, 2023
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8XQB
 | | Mature virion portal vertex of bacteriophage lambda | | Descriptor: | Capsid decoration protein, Head completion protein, Head-tail connector protein FII, ... | | Authors: | Wang, J.W, Gu, Z.W. | | Deposit date: | 2024-01-05 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda.
J.Virol., 98, 2024
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8XOW
 | | Mature virion portal of bacteriophage lambda | | Descriptor: | Head completion protein, Head-tail connector protein FII, Portal protein B, ... | | Authors: | Wang, J.W, Gu, Z.W. | | Deposit date: | 2024-01-02 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.32 Å) | | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda.
J.Virol., 98, 2024
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8XOU
 | | Prohead portal vertex of bacteriophage lambda | | Descriptor: | Major capsid protein, Portal protein B | | Authors: | Wang, J.W, Gu, Z.W. | | Deposit date: | 2024-01-02 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (5.58 Å) | | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda.
J.Virol., 98, 2024
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8XOT
 | | Prohead portal of bacteriophage lambda | | Descriptor: | Portal protein B | | Authors: | Wang, J.W, Gu, Z.W. | | Deposit date: | 2024-01-02 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda.
J.Virol., 98, 2024
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8XPM
 | | Mature virion portal of phage lambda with DNA | | Descriptor: | DNA (104-MER), DNA (92-MER), Head completion protein, ... | | Authors: | Wang, J.W, Gu, Z.W. | | Deposit date: | 2024-01-04 | | Release date: | 2024-04-10 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural morphing in the viral portal vertex of bacteriophage lambda.
J.Virol., 98, 2024
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8XCI
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8XCK
 | | Closed state of central tail fiber of bacteriophage lambda | | Descriptor: | Peptidyl-prolyl cis-trans isomerase A, Tip attachment protein J | | Authors: | Ge, X.F, Wang, J.W. | | Deposit date: | 2023-12-09 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor.
Nat Commun, 15, 2024
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8XCG
 | | Tail tip complex of bacteriophage lambda in the open state | | Descriptor: | IRON/SULFUR CLUSTER, Tail tip assembly protein I, Tail tip protein L, ... | | Authors: | Ge, X.F, Wang, J.W. | | Deposit date: | 2023-12-09 | | Release date: | 2024-05-01 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Structural mechanism of bacteriophage lambda tail's interaction with the bacterial receptor.
Nat Commun, 15, 2024
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8XCJ
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4LGI
 | | N-terminal truncated NleC structure | | Descriptor: | Uncharacterized protein | | Authors: | Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W. | | Deposit date: | 2013-06-28 | | Release date: | 2014-01-15 | | Last modified: | 2015-02-25 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
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4LGJ
 | | Crystal structure and mechanism of a type III secretion protease | | Descriptor: | Uncharacterized protein, ZINC ION | | Authors: | Li, W.Q, Liu, Y.X, Sheng, X.L, Yan, C.Y, Wang, J.W. | | Deposit date: | 2013-06-28 | | Release date: | 2014-01-15 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure and mechanism of a type III secretion protease, NleC
Acta Crystallogr.,Sect.D, 70, 2014
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4M9Z
 | | Crystal structure of CED-4 bound CED-3 fragment | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CED-3 fragment, Cell death protein 4, ... | | Authors: | Huang, W.J, Jinag, T.Y, Choi, W.Y, Wang, J.W, Shi, Y.G. | | Deposit date: | 2013-08-15 | | Release date: | 2013-10-23 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (3.405 Å) | | Cite: | Mechanistic insights into CED-4-mediated activation of CED-3.
Genes Dev., 27, 2013
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6A06
 | | Structure of pSTING complex | | Descriptor: | SULFATE ION, Stimulator of interferon genes protein, cGAMP | | Authors: | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.792 Å) | | Cite: | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
J.Biol.Chem., 294, 2019
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6A04
 | | Structure of pSTING complex | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SULFATE ION, Stimulator of interferon genes protein | | Authors: | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
J.Biol.Chem., 294, 2019
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7CI1
 | | Crystal structure of AcrVA2 | | Descriptor: | 1,2-ETHANEDIOL, AcrVA2, SPERMIDINE | | Authors: | Chen, P, Cheng, Z, Wang, Y. | | Deposit date: | 2020-07-07 | | Release date: | 2020-10-14 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural Study on Anti-CRISPR Protein AcrVA2
Prog.Biochem.Biophys., 2021
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7CI2
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6K1H
 | | Structure of membrane protein | | Descriptor: | PTS mannose transporter subunit IID, PTS system mannose-specific EIIC component, alpha-D-mannopyranose | | Authors: | Wang, J.W, Zeng, J.W. | | Deposit date: | 2019-05-10 | | Release date: | 2019-07-10 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.52 Å) | | Cite: | Structure of the mannose transporter of the bacterial phosphotransferase system.
Cell Res., 29, 2019
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6A05
 | | Structure of pSTING complex | | Descriptor: | 2-amino-9-[(2R,3R,3aR,5S,7aS,9R,10R,10aR,12R,14aS)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, SULFATE ION, Stimulator of interferon genes protein | | Authors: | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
J.Biol.Chem., 294, 2019
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6A03
 | | Structure of pSTING complex | | Descriptor: | (2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-2,9-bis(6-amino-9H-purin-9-yl)octahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8 ]tetraoxadiphosphacyclododecine-3,5,10,12-tetrol 5,12-dioxide, SULFATE ION, Stimulator of interferon genes protein | | Authors: | Yuan, Z.L, Shang, G.J, Cong, X.Y, Gu, L.C. | | Deposit date: | 2018-06-05 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (2.597 Å) | | Cite: | Crystal structures of porcine STINGCBD-CDN complexes reveal the mechanism of ligand recognition and discrimination of STING proteins.
J.Biol.Chem., 294, 2019
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5XNE
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5XOB
 | | Crystal structure of apo TiaS (tRNAIle2 agmatidine synthetase) | | Descriptor: | MAGNESIUM ION, ZINC ION, tRNA(Ile2) 2-agmatinylcytidine synthetase TiaS | | Authors: | Dong, J. | | Deposit date: | 2017-05-27 | | Release date: | 2018-08-29 | | Last modified: | 2018-10-24 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Structure of tRNA-Modifying Enzyme TiaS and Motions of Its Substrate Binding Zinc Ribbon.
J. Mol. Biol., 430, 2018
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5T5G
 | | human SETD8 in complex with MS2177 | | Descriptor: | 7-(2-aminoethoxy)-6-methoxy-2-(pyrrolidin-1-yl)-N-[5-(pyrrolidin-1-yl)pentyl]quinazolin-4-amine, N-lysine methyltransferase KMT5A, UNKNOWN ATOM OR ION | | Authors: | Yu, W, Tempel, W, Babault, N, Ma, A, Butler, K.V, Jin, J, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Brown, P.J, Structural Genomics Consortium (SGC) | | Deposit date: | 2016-08-30 | | Release date: | 2016-09-28 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-Based Design of a Covalent Inhibitor of the SET Domain-Containing Protein 8 (SETD8) Lysine Methyltransferase.
J. Med. Chem., 59, 2016
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8JX7
 | | Cryo-EM structure of human ABC transporter ABCC2 | | Descriptor: | ATP-binding cassette sub-family C member 2 | | Authors: | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | | Deposit date: | 2023-06-30 | | Release date: | 2024-01-03 | | Last modified: | 2024-02-28 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain.
Nat Commun, 15, 2024
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