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CHK1 kinase domain in complex with aminopyrazine compound 13
Descriptor:	4-[3-amino-6-(3-hydroxyphenyl)pyrazin-2-yl]benzoic acid, Serine/threonine-protein kinase Chk1
Authors:	Appleton, B, Wu, P.
Deposit date:	2014-07-24
Release date:	2014-12-17
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Discovery of the 1,7-diazacarbazole class of inhibitors of checkpoint kinase 1. Bioorg.Med.Chem.Lett., 24, 2014

Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform
Descriptor:	N~2~-{2-chloro-4-[(4-methylpiperazin-1-yl)carbonyl]phenyl}-N~2~,N~8~-dimethyl-4,5-dihydrothieno[3,2-d][1]benzoxepine-2,8-dicarboxamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Authors:	Murray, J.M, Wiesmann, C.
Deposit date:	2011-08-01
Release date:	2011-11-16
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Rational Design of PI3K-alpha Inhibitors that Exhibit Selectivity Over the PI3K-beta Isoform To be Published