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6CZG
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BU of 6czg by Molmil
Structure of a redesigned beta barrel, b11L5F_LGL
Descriptor: b11L5F_LGL
Authors:Doyle, L.A, Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
6CZJ
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BU of 6czj by Molmil
Structure of a redesigned beta barrel, b10
Descriptor: SULFATE ION, b10
Authors:Doyle, L.A, Stoddard, B.L.
Deposit date:2018-04-09
Release date:2018-09-19
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:De novo design of a fluorescence-activating beta-barrel.
Nature, 561, 2018
3UGM
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BU of 3ugm by Molmil
Structure of TAL effector PthXo1 bound to its DNA target
Descriptor: DNA-1, DNA-2, TAL effector AvrBs3/PthA
Authors:Mak, A.N.S, Bradley, P, Cernadas, R.A, Bogdanove, A.J, Stoddard, B.L.
Deposit date:2011-11-02
Release date:2012-01-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:The Crystal Structure of TAL Effector PthXo1 Bound to Its DNA Target.
Science, 335, 2012
5TH3
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BU of 5th3 by Molmil
Restriction/modification system-Type II R.SwaI cleaved DNA complex
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DNA (cleaved 25-MER, ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2016-09-29
Release date:2016-12-21
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.
Nucleic Acids Res., 45, 2017
5TGX
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BU of 5tgx by Molmil
Restriction/modification system-Type II R-SwaI complexed with partially cleaved DNA
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2016-09-28
Release date:2016-12-21
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.
Nucleic Acids Res., 45, 2017
3T1G
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BU of 3t1g by Molmil
Engineering of organophosphate hydrolase by computational design and directed evolution
Descriptor: CALCIUM ION, ZINC ION, organophosphate hydrolase
Authors:Takeuchi, R, Stoddard, B.L.
Deposit date:2011-07-21
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat.Chem.Biol., 8, 2012
6EG7
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BU of 6eg7 by Molmil
BbvCI B2 dimer with I3C clusters
Descriptor: 1,2-ETHANEDIOL, 5-amino-2,4,6-triiodobenzene-1,3-dicarboxylic acid, BbvCI endonuclease subunit 2, ...
Authors:Shen, B.W, Stoddard, B.L.
Deposit date:2018-08-19
Release date:2018-11-14
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure, subunit organization and behavior of the asymmetric Type IIT restriction endonuclease BbvCI.
Nucleic Acids Res., 47, 2019
5THG
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BU of 5thg by Molmil
Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI
Descriptor: CALCIUM ION, DNA (29-MER), GLYCEROL, ...
Authors:Hallinan, J.P, Stoddard, B.L.
Deposit date:2016-09-29
Release date:2017-05-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.106 Å)
Cite:The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering
to be published
5TGQ
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BU of 5tgq by Molmil
Restriction-modification system Type II R.SwaI, DNA free
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, CALCIUM ION, ...
Authors:Shen, B.W, stoddard, B.L.
Deposit date:2016-09-28
Release date:2016-12-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:DNA recognition by the SwaI restriction endonuclease involves unusual distortion of an 8 base pair A:T-rich target.
Nucleic Acids Res., 45, 2017
1IDC
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BU of 1idc by Molmil
ISOCITRATE DEHYDROGENASE FROM E.COLI (MUTANT K230M), STEADY-STATE INTERMEDIATE COMPLEX DETERMINED BY LAUE CRYSTALLOGRAPHY
Descriptor: 2-OXALOSUCCINIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION
Authors:Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
1IDD
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BU of 1idd by Molmil
ISOCITRATE DEHYDROGENASE Y160F MUTANT APO ENZYME
Descriptor: ISOCITRATE DEHYDROGENASE
Authors:Lee, M.E, Dyer, D.H, Klein, O.D, Bolduc, J.M, Stoddard, B.L, Koshland Junior, D.E.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
3QQY
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BU of 3qqy by Molmil
Crystal structure of a novel LAGLIDADG homing endonuclease, I-OnuI (from Ophiostoma novo-ulmi subsp. americana)
Descriptor: DNA (26-MER), MAGNESIUM ION, Ribosomal protein 3/homing endonuclease-like protein fusion
Authors:Takeuchi, R, Stoddard, B.L.
Deposit date:2011-02-16
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
1IDF
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BU of 1idf by Molmil
ISOCITRATE DEHYDROGENASE K230M MUTANT APO ENZYME
Descriptor: ISOCITRATE DEHYDROGENASE
Authors:Bolduc, J.M, Dyer, D.H, Scott, W.G, Singer, P, Sweet, R.M, Koshland Junior, D.E, Stoddard, B.L.
Deposit date:1995-01-18
Release date:1996-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutagenesis and Laue structures of enzyme intermediates: isocitrate dehydrogenase.
Science, 268, 1995
3R7P
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BU of 3r7p by Molmil
The crystal structure of I-LtrI
Descriptor: DNA (5'-D(*CP*AP*AP*AP*TP*GP*CP*TP*CP*CP*TP*AP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*GP*CP*AP*TP*TP*TP*G)-3'), ...
Authors:Mak, A.N.S, Takeuchi, R, Edgell, D.R, Stoddard, B.L.
Deposit date:2011-03-22
Release date:2011-07-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
1K6W
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BU of 1k6w by Molmil
The Structure of Escherichia coli Cytosine Deaminase
Descriptor: Cytosine Deaminase, FE (III) ION
Authors:Ireton, G.C, McDermott, G, Black, M.E, Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
3R3P
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BU of 3r3p by Molmil
Homing Endonuclease I-Bth0305I Catalytic Domain
Descriptor: Mobile intron protein
Authors:Taylor, G.K, Stoddard, B.L.
Deposit date:2011-03-16
Release date:2011-10-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family.
Nucleic Acids Res., 39, 2011
1K70
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BU of 1k70 by Molmil
The Structure of Escherichia coli Cytosine Deaminase bound to 4-Hydroxy-3,4-Dihydro-1H-Pyrimidin-2-one
Descriptor: 4-HYDROXY-3,4-DIHYDRO-1H-PYRIMIDIN-2-ONE, Cytosine Deaminase, FE (III) ION
Authors:Ireton, G.C, McDermott, G, Black, M.E, Stoddard, B.L.
Deposit date:2001-10-17
Release date:2002-02-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of Escherichia coli cytosine deaminase.
J.Mol.Biol., 315, 2002
3S1S
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BU of 3s1s by Molmil
Characterization and crystal structure of the type IIG restriction endonuclease BpuSI
Descriptor: 1,2-ETHANEDIOL, IODIDE ION, MANGANESE (II) ION, ...
Authors:Shen, B.W, Xu, D, Chan, S.-H, Zheng, Y, Zhu, Y, Xu, S.-Y, Stoddard, B.L.
Deposit date:2011-05-16
Release date:2011-07-13
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI.
Nucleic Acids Res., 39, 2011
1LTQ
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BU of 1ltq by Molmil
CRYSTAL STRUCTURE OF T4 POLYNUCLEOTIDE KINASE
Descriptor: ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, POLYNUCLEOTIDE KINASE
Authors:Galburt, E.A, Pelletier, J, Wilson, G, Stoddard, B.L.
Deposit date:2002-05-20
Release date:2002-10-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Structure of a tRNA repair enzyme and molecular biology workhorse: T4 polynucleotide kinase.
Structure, 10, 2002
1N3F
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BU of 1n3f by Molmil
Crystal structure of I-CreI bound to a palindromic DNA sequence II (palindrome of right side of wildtype DNA target sequence)
Descriptor: 5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*GP*A)-3', 5'-D(P*GP*AP*CP*AP*GP*TP*TP*TP*CP*G-3'), CALCIUM ION, ...
Authors:Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L.
Deposit date:2002-10-28
Release date:2003-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003
1A3X
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BU of 1a3x by Molmil
PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH PG, MN2+ AND K+
Descriptor: 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, POTASSIUM ION, ...
Authors:Jurica, M.S, Mesecar, A, Heath, P.J, Shi, W, Nowak, T, Stoddard, B.L.
Deposit date:1998-01-26
Release date:1998-05-27
Last modified:2024-12-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Structure, 6, 1998
1A3W
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BU of 1a3w by Molmil
PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH FBP, PG, MN2+ AND K+
Descriptor: 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ...
Authors:Jurica, M.S, Mesecar, A, Heath, P.J, Shi, W, Nowak, T, Stoddard, B.L.
Deposit date:1998-01-26
Release date:1998-05-27
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Structure, 6, 1998
1AF5
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BU of 1af5 by Molmil
GROUP I MOBILE INTRON ENDONUCLEASE
Descriptor: I-CREI
Authors:Heath, P.J, Stephens, K.M, Monnat Junior, R.J, Stoddard, B.L.
Deposit date:1997-03-21
Release date:1997-07-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of I-Crel, a group I intron-encoded homing endonuclease.
Nat.Struct.Biol., 4, 1997
1B0A
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BU of 1b0a by Molmil
5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI.
Descriptor: PROTEIN (FOLD BIFUNCTIONAL PROTEIN)
Authors:Shen, B.W, Dyer, D, Huang, J.-Y, D'Ari, L, Rabinowitz, J, Stoddard, B.L.
Deposit date:1998-11-06
Release date:1999-06-29
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase.
Protein Sci., 8, 1999
1N3E
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BU of 1n3e by Molmil
Crystal structure of I-CreI bound to a palindromic DNA sequence I (palindrome of left side of wildtype DNA target sequence)
Descriptor: 5'-D(*CP*GP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*C)-3', 5'-D(P*GP*AP*CP*GP*TP*TP*TP*TP*CP*G)-3', CALCIUM ION, ...
Authors:Chevalier, B, Turmel, M, Lemieux, C, Monnat, R.J, Stoddard, B.L.
Deposit date:2002-10-28
Release date:2003-06-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Flexible DNA Target Site Recognition by Divergent Homing Endonuclease Isoschizomers I-CreI and I-MsoI
J.Mol.Biol., 329, 2003

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