7ZTM
 
 | | Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2128 | | Descriptor: | 1-[(5R,8R,15S,18S)-15-(4-azanylbutyl)-5-(cyclohexylmethyl)-18-(naphthalen-2-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, Serine protease NS3, Serine protease subunit NS2B | | Authors: | Huber, S, Steinmetzer, T. | | Deposit date: | 2022-05-10 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.
Arch Pharm, 2024
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7ZUM
 | | Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2130 | | Descriptor: | 1-[(5R,8R,15S,18S)-15-(4-azanylbutyl)-5-(cyclohexylmethyl)-18-(1H-indol-3-ylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, Serine protease NS3, Serine protease subunit NS2B | | Authors: | Huber, S, Steinmetzer, T. | | Deposit date: | 2022-05-12 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.
Arch Pharm, 2024
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7ZV4
 | | Crystal Structure of Unlinked NS2B-NS3 Protease from Zika Virus in Complex with Inhibitor MI-2195 | | Descriptor: | 1-[(5R,8R,15S,18S)-15-[[3-(aminomethyl)phenyl]methyl]-18-(4-azanylbutyl)-5-(cyclohexylmethyl)-4,7,14,17,20-pentakis(oxidanylidene)-3,6,13,16,19-pentazabicyclo[20.3.1]hexacosa-1(25),22(26),23-trien-8-yl]guanidine, Serine protease NS3, Serine protease subunit NS2B | | Authors: | Huber, S, Steinmetzer, T. | | Deposit date: | 2022-05-13 | | Release date: | 2023-03-22 | | Last modified: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease.
Arch Pharm, 2024
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3HE7
 | | Crystal structure of mouse CD1d-alpha-galactosylceramide with mouse Valpha14-Vbeta7 NKT TCR | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antigen-presenting glycoprotein CD1d1, ... | | Authors: | Patel, O, Rossjohn, J. | | Deposit date: | 2009-05-08 | | Release date: | 2009-07-28 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Differential recognition of CD1d-alpha-galactosyl ceramide by the V beta 8.2 and V beta 7 semi-invariant NKT T cell receptors
Immunity, 31, 2009
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3I3L
 | | Crystal structure of CmlS, a flavin-dependent halogenase | | Descriptor: | Alkylhalidase CmlS, FLAVIN-ADENINE DINUCLEOTIDE | | Authors: | Podzelinska, K, Soares, A, Jia, Z, Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) | | Deposit date: | 2009-06-30 | | Release date: | 2010-03-09 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Chloramphenicol Biosynthesis: The Structure of CmlS, a Flavin-Dependent Halogenase Showing a Covalent Flavin-Aspartate Bond
J.Mol.Biol., 397, 2010
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3HUJ
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7LJ1
 | | Human Prx1-Srx Decameric Complex | | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE-5'-TRIPHOSPHATE, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Forshaw, T.E, Reisz, J.A, Nelson, K.J, Gumpena, R, Lawson, J.R, Jonsson, T, Wu, H, Clodfelter, J.E, Johnson, L, Furdui, C.M, Lowther, W.T. | | Deposit date: | 2021-01-28 | | Release date: | 2021-07-14 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Specificity of Human Sulfiredoxin for Reductant and Peroxiredoxin Oligomeric State.
Antioxidants (Basel), 10, 2021
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7LII
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S7D | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.55 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIL
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant SE3 | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIM
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S6E | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.75 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIJ
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S1K | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIK
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S1R | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.91 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIS
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S5D | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.96 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7LIT
 | | Thermotoga maritima Encapsulin Nanocompartment Pore Mutant S7G | | Descriptor: | Maritimacin, RIBOFLAVIN | | Authors: | Andreas, M.P, Adamson, L, Tasneem, N, Close, W, Giessen, T, Lau, Y.H. | | Deposit date: | 2021-01-27 | | Release date: | 2022-02-09 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (2.53 Å) | | Cite: | Pore structure controls stability and molecular flux in engineered protein cages.
Sci Adv, 8, 2022
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7MHC
 | | Structure of human STING in complex with MK-1454 | | Descriptor: | (2R,5R,7R,8S,10R,12aR,14R,15S,15aR,16R)-7-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-14-(6-amino-9H-purin-9-yl)-15,16-difluoro-2,10-bis(sulfanyl)octahydro-2H,10H,12H-5,8-methano-2lambda~5~,10lambda~5~-furo[3,2-l][1,3,6,9,11,2,10]pentaoxadiphosphacyclotetradecine-2,10-dione, Stimulator of interferon genes protein | | Authors: | Lesburg, C.A. | | Deposit date: | 2021-04-15 | | Release date: | 2022-04-06 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | A kinase-cGAS cascade to synthesize a therapeutic STING activator.
Nature, 603, 2022
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7NPD
 | | Vibiro cholerae ParA2 | | Descriptor: | Walker A-type ATPase | | Authors: | Parker, A.V, Bergeron, J.R.C. | | Deposit date: | 2021-02-26 | | Release date: | 2021-05-19 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The structure of the bacterial DNA segregation ATPase filament reveals the conformational plasticity of ParA upon DNA binding.
Nat Commun, 12, 2021
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7N5S
 | | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 6) | | Descriptor: | DNA Strand I, DNA Strand II, ZINC ION, ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2021-06-06 | | Release date: | 2021-08-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.86 Å) | | Cite: | Structural basis for human ZBTB7A action at the fetal globin promoter.
Cell Rep, 36, 2021
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7N5T
 | | ZBTB7A Zinc Finger Domain Bound to -200 Site of Fetal Globin Promoter (Oligo 5) | | Descriptor: | DNA Strand I, DNA Strand II, ZINC ION, ... | | Authors: | Horton, J.R, Ren, R, Cheng, X. | | Deposit date: | 2021-06-06 | | Release date: | 2021-08-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis for human ZBTB7A action at the fetal globin promoter.
Cell Rep, 36, 2021
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7NPF
 | | Vibrio cholerae ParA2-ATPyS-DNA filament | | Descriptor: | AAA family ATPase, DNA (49-MER), MAGNESIUM ION, ... | | Authors: | Parker, A.V, Bergeron, J.R.C. | | Deposit date: | 2021-02-26 | | Release date: | 2021-10-06 | | Last modified: | 2021-10-20 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | The structure of the bacterial DNA segregation ATPase filament reveals the conformational plasticity of ParA upon DNA binding.
Nat Commun, 12, 2021
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7NLV
 | | WILDTYPE CORE-STREPTAVIDIN WITH a conjugated BIOTINYLATED PYRROLIDINE II | | Descriptor: | 5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-((S)-pyrrolidin-3-yl)pentanamide, Streptavidin | | Authors: | Nodling, A.R, Santi, N, Tsai, Y.H, Rizkallah, P, Luk, L.Y.P, Jin, Y. | | Deposit date: | 2021-02-22 | | Release date: | 2022-03-02 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | The role of streptavidin and its variants in catalysis by biotinylated secondary amines.
Org.Biomol.Chem., 19, 2021
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7NPE
 | | Vibrio cholerae ParA2-ADP | | Descriptor: | AAA family ATPase, ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, ... | | Authors: | Parker, A.V, Bergeron, J.R.C. | | Deposit date: | 2021-02-26 | | Release date: | 2021-07-21 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The cryo-EM structure of the bacterial type I segregation filament reveals ParA s conformational plasticity upon DNA binding
To Be Published
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7N6E
 | | TCR peptide HLA-A2 complex | | Descriptor: | Beta-2-microglobulin, MHC class I antigen, Spike protein S1, ... | | Authors: | Chaurasia, P, Rossjohn, J, Petersen, J. | | Deposit date: | 2021-06-08 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
J.Biol.Chem., 297, 2021
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7N6D
 | | HLA peptide complex | | Descriptor: | 1,2-ETHANEDIOL, Beta-2-microglobulin, MHC class I antigen, ... | | Authors: | Chaurasia, P, Petersen, J, Rossjohn, J. | | Deposit date: | 2021-06-08 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural basis of biased T cell receptor recognition of an immunodominant HLA-A2 epitope of the SARS-CoV-2 spike protein.
J.Biol.Chem., 297, 2021
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7MU9
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4JQX
 | | HLA-B*44:03 in complex with Epstein-Barr virus BZLF1-derived peptide (residues 169-180) | | Descriptor: | ACETATE ION, Beta-2-microglobulin, GLYCEROL, ... | | Authors: | Theodossis, A, Welland, A, Gras, S, Rossjohn, J. | | Deposit date: | 2013-03-20 | | Release date: | 2013-06-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | HLA Peptide Length Preferences Control CD8+ T Cell Responses.
J.Immunol., 191, 2013
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