7D5F
 
 | | Left-handed G-quadruplex containing 3 bulges | | Descriptor: | 3xBulge-LHG4motif | | Authors: | Winnerdy, F.R, Das, P, Ngo, K.H, Maity, A, Bakalar, B, Mechulam, Y, Schmitt, E, Phan, A.T. | | Deposit date: | 2020-09-25 | | Release date: | 2021-02-10 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Bulges in left-handed G-quadruplexes.
Nucleic Acids Res., 49, 2021
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2FMT
 | | METHIONYL-TRNAFMET FORMYLTRANSFERASE COMPLEXED WITH FORMYL-METHIONYL-TRNAFMET | | Descriptor: | FORMYL-METHIONYL-TRNAFMET2, MAGNESIUM ION, METHIONYL-TRNA FMET FORMYLTRANSFERASE, ... | | Authors: | Schmitt, E, Mechulam, Y, Blanquet, S. | | Deposit date: | 1998-07-29 | | Release date: | 1999-07-29 | | Last modified: | 2023-08-02 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure of methionyl-tRNAfMet transformylase complexed with the initiator formyl-methionyl-tRNAfMet.
EMBO J., 17, 1998
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7ZHG
 | | High-resolution cryo-EM structure of Pyrococcus abyssi 30S ribosomal subunit bound to mRNA and initiator tRNA anticodon stem-loop | | Descriptor: | 30S ribosomal protein S10, 30S ribosomal protein S11, 30S ribosomal protein S12, ... | | Authors: | Kazan, R, Bourgeois, G, Mechulam, Y, Coureux, P.D, Schmitt, E. | | Deposit date: | 2022-04-06 | | Release date: | 2022-06-29 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (2.25 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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7ZKI
 | | Cryo-EM structure of aIF1A:aIF5B:Met-tRNAiMet complex from a Pyrococcus abyssi 30S initiation complex | | Descriptor: | MAGNESIUM ION, METHIONINE, Met-tRNAiMet, ... | | Authors: | Coureux, P.D, Bourgeois, G, Mechulam, Y, Schmitt, E, Kazan, R. | | Deposit date: | 2022-04-13 | | Release date: | 2022-07-20 | | Last modified: | 2022-08-31 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Role of aIF5B in archaeal translation initiation.
Nucleic Acids Res., 50, 2022
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8BRW
 | | Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C | | Descriptor: | Methionine--tRNA ligase, ZINC ION | | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.73 Å) | | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
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8BRX
 | | Escherichia coli methionyl-tRNA synthetase mutant L13C,I297C complexed with beta-3-methionine | | Descriptor: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
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8BRV
 | | Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C complexed with beta3-methionine. | | Descriptor: | (3R)-3-amino-5-(methylsulfanyl)pentanoic acid, CITRIC ACID, Methionine--tRNA ligase, ... | | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-16 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.53 Å) | | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
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8BRU
 | | Escherichia coli methionyl-tRNA synthetase mutant L13M,I297C | | Descriptor: | CITRIC ACID, Methionine--tRNA ligase, ZINC ION | | Authors: | Schmitt, E, Mechulam, Y, Nigro, G, Opuu, V, Lazennec-Schurdevin, C, Simonson, T. | | Deposit date: | 2022-11-24 | | Release date: | 2023-08-16 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Redesigning methionyl-tRNA synthetase for beta-methionine activity with adaptive landscape flattening and experiments.
Protein Sci., 32, 2023
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1KJZ
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1KK2
 | | Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi-G235D mutant complexed with GDP-Mg2+ | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ZINC ION, ... | | Authors: | Schmitt, E, Blanquet, S, Mechulam, Y. | | Deposit date: | 2001-12-06 | | Release date: | 2002-04-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
EMBO J., 21, 2002
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3FRH
 | | Structure of the 16S rRNA methylase RmtB, P21 | | Descriptor: | 16S rRNA methylase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schmitt, E, Galimand, M, Panvert, M, Dupechez, M, Courvalin, P, Mechulam, Y. | | Deposit date: | 2009-01-08 | | Release date: | 2009-08-11 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J.Mol.Biol., 388, 2009
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1KK1
 | | Structure of the large gamma subunit of initiation factor eIF2 from Pyrococcus abyssi-G235D mutant complexed with GDPNP-Mg2+ | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ZINC ION, ... | | Authors: | Schmitt, E, Blanquet, S, Mechulam, Y. | | Deposit date: | 2001-12-06 | | Release date: | 2002-04-10 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The large subunit of initiation factor aIF2 is a close structural homologue of elongation factors.
EMBO J., 21, 2002
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3FZG
 | | Structure of the 16S rRNA methylase ArmA | | Descriptor: | 16S rRNA methylase, S-ADENOSYLMETHIONINE | | Authors: | Schmitt, E, Galimand, M, Panvert, M, Courvalin, P, Mechulam, Y. | | Deposit date: | 2009-01-26 | | Release date: | 2009-08-11 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J.Mol.Biol., 388, 2009
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3FRI
 | | Structure of the 16S rRNA methylase RmtB, I222 | | Descriptor: | 16S rRNA methylase, S-ADENOSYL-L-HOMOCYSTEINE | | Authors: | Schmitt, E, Galimand, M, Panvert, M, Dupechez, M, Courvalin, P, Mechulam, Y. | | Deposit date: | 2009-01-08 | | Release date: | 2009-08-11 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural bases for 16 S rRNA methylation catalyzed by ArmA and RmtB methyltransferases
J.Mol.Biol., 388, 2009
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1MKH
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3H9B
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with azidonorleucine | | Descriptor: | 6-azido-L-norleucine, CITRIC ACID, Methionyl-tRNA synthetase, ... | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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3H99
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity complexed with methionine | | Descriptor: | CITRIC ACID, METHIONINE, Methionyl-tRNA synthetase, ... | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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3H97
 | | Structure of a mutant methionyl-tRNA synthetase with modified specificity | | Descriptor: | CITRIC ACID, Methionyl-tRNA synthetase, ZINC ION | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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3H9C
 | | Structure of methionyl-tRNA synthetase: crystal form 2 | | Descriptor: | CITRIC ACID, Methionyl-tRNA synthetase, ZINC ION | | Authors: | Schmitt, E, Tanrikulu, I.C, Yoo, T.H, Panvert, M, Tirrell, D.A, Mechulam, Y. | | Deposit date: | 2009-04-30 | | Release date: | 2009-12-08 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Switching from an induced-fit to a lock-and-key mechanism in an aminoacyl-tRNA synthetase with modified specificity.
J.Mol.Biol., 394, 2009
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2PTH
 | | PEPTIDYL-TRNA HYDROLASE FROM ESCHERICHIA COLI | | Descriptor: | PEPTIDYL-TRNA HYDROLASE | | Authors: | Schmitt, E, Mechulam, Y, Fromant, M, Plateau, P, Blanquet, S. | | Deposit date: | 1997-03-25 | | Release date: | 1998-03-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Crystal structure at 1.2 A resolution and active site mapping of Escherichia coli peptidyl-tRNA hydrolase.
EMBO J., 16, 1997
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2QMU
 | | Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, Translation initiation factor 2 alpha subunit, ... | | Authors: | Yatime, L, Mechulam, Y, Blanquet, S, Schmitt, E. | | Deposit date: | 2007-07-17 | | Release date: | 2007-11-06 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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1FMT
 | | METHIONYL-TRNAFMET FORMYLTRANSFERASE FROM ESCHERICHIA COLI | | Descriptor: | METHIONYL-TRNA FMET FORMYLTRANSFERASE | | Authors: | Schmitt, E, Mechulam, Y. | | Deposit date: | 1997-10-13 | | Release date: | 1998-01-28 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of crystalline Escherichia coli methionyl-tRNA(f)Met formyltransferase: comparison with glycinamide ribonucleotide formyltransferase.
EMBO J., 15, 1996
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3M4X
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1JKE
 | | D-Tyr tRNATyr deacylase from Escherichia coli | | Descriptor: | D-Tyr-tRNATyr deacylase, ZINC ION | | Authors: | Ferri-Fioni, M.L, Schmitt, E, Soutourina, J, Plateau, P, Mechulam, Y, Blanquet, S. | | Deposit date: | 2001-07-12 | | Release date: | 2002-01-25 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure of crystalline D-Tyr-tRNA(Tyr) deacylase. A representative of a new class of tRNA-dependent hydrolases.
J.Biol.Chem., 276, 2001
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4MNO
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