7ZG5
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![BU of 7zg5 by Molmil](/molmil-images/mine/7zg5) | The crystal structure of Salmonella TacAT3-DNA complex | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, Acetyltransferase, BARIUM ION, ... | Authors: | Grabe, G.J, Morgan, R.M.L, Helaine, S. | Deposit date: | 2022-04-01 | Release date: | 2023-10-11 | Last modified: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular stripping underpins derepression of a toxin-antitoxin system. Nat.Struct.Mol.Biol., 2024
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6FJY
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![BU of 6fjy by Molmil](/molmil-images/mine/6fjy) | Crystal structure of CsuC-CsuE chaperone-tip adhesion subunit pre-assembly complex from archaic chaperone-usher Csu pili of Acinetobacter baumannii | Descriptor: | CsuC, Protein CsuE | Authors: | Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A.V. | Deposit date: | 2018-01-23 | Release date: | 2018-05-16 | Last modified: | 2018-09-19 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural basis forAcinetobacter baumanniibiofilm formation. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6FM5
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![BU of 6fm5 by Molmil](/molmil-images/mine/6fm5) | Crystal structure of self-complemented CsuA/B major subunit from archaic chaperone-usher Csu pili of Acinetobacter baumannii | Descriptor: | CsuA/B,CsuA/B,CsuA/B,CsuA/B | Authors: | Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A.V. | Deposit date: | 2018-01-30 | Release date: | 2018-09-26 | Last modified: | 2018-11-14 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information. J. Biol. Chem., 293, 2018
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6FQ0
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![BU of 6fq0 by Molmil](/molmil-images/mine/6fq0) | Crystal structure of the CsuC-CsuA/B chaperone-subunit preassembly complex of the archaic chaperone-usher Csu pili of Acinetobacter baumannii | Descriptor: | CsuA/B,CsuA/B, CsuC | Authors: | Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A.V. | Deposit date: | 2018-02-12 | Release date: | 2018-09-26 | Last modified: | 2018-11-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information. J. Biol. Chem., 293, 2018
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6FQA
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![BU of 6fqa by Molmil](/molmil-images/mine/6fqa) | Crystal structure of the CsuC-CsuA/B chaperone-subunit preassembly complex of the archaic chaperone-usher Csu pili of Acinetobacter baumannii | Descriptor: | CsuA/B,CsuA/B, CsuC | Authors: | Parilova, O, Pakharukova, N.A, Malmi, H, Tuitilla, M, Paavilainen, S, Zavialov, A.V. | Deposit date: | 2018-02-13 | Release date: | 2018-09-26 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Archaic and alternative chaperones preserve pilin folding energy by providing incomplete structural information. J. Biol. Chem., 293, 2018
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1KO7
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![BU of 1ko7 by Molmil](/molmil-images/mine/1ko7) | X-ray structure of the HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution | Descriptor: | Hpr kinase/phosphatase, PHOSPHATE ION | Authors: | Marquez, J.A, Hasenbein, S, Koch, B, Fieulaine, S, Nessler, S, Hengstenberg, W, Scheffzek, K. | Deposit date: | 2001-12-20 | Release date: | 2002-04-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions. Proc.Natl.Acad.Sci.USA, 99, 2002
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5D6H
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![BU of 5d6h by Molmil](/molmil-images/mine/5d6h) | Crystal structure of CsuC-CsuA/B chaperone-major subunit pre-assembly complex from Csu biofilm-mediating pili of Acinetobacter baumannii | Descriptor: | CsuA/B, CsuC | Authors: | Pakharukova, N.A, Tuitilla, M, Paavilainen, S, Zavialov, A. | Deposit date: | 2015-08-12 | Release date: | 2015-11-04 | Last modified: | 2015-12-02 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural Insight into Archaic and Alternative Chaperone-Usher Pathways Reveals a Novel Mechanism of Pilus Biogenesis. Plos Pathog., 11, 2015
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2KN8
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![BU of 2kn8 by Molmil](/molmil-images/mine/2kn8) | NMR structure of the C-terminal domain of pUL89 | Descriptor: | DNA cleavage and packaging protein large subunit, UL89 | Authors: | Couvreux, A, Hantz, S, Marquant, R, Champier, G, Alain, S, Morellet, N, Bouaziz, S. | Deposit date: | 2009-08-18 | Release date: | 2010-06-09 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Insight into the structure of the pUL89 C-terminal domain of the human cytomegalovirus terminase complex. Proteins, 78, 2010
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6G96
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![BU of 6g96 by Molmil](/molmil-images/mine/6g96) | Crystal structure of TacT3 (tRNA acetylating toxin) from Salmonella | Descriptor: | ACETYL COENZYME *A, Acetyltransferase, BICINE, ... | Authors: | Grabe, G.J, Rycroft, J.A, Gollan, B, Hall, A, Cheverton, A.M, Larrouy-Maumus, G, Hare, S.A, Helaine, S. | Deposit date: | 2018-04-10 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4766078 Å) | Cite: | Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection. Nat Commun, 9, 2018
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7ZL4
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![BU of 7zl4 by Molmil](/molmil-images/mine/7zl4) | Cryo-EM structure of archaic chaperone-usher Csu pilus of Acinetobacter baumannii | Descriptor: | CsuA/B | Authors: | Pakharukova, N, Malmi, H, Tuittila, M, Paavilainen, S, Ghosal, D, Chang, Y.W, Jensen, G.J, Zavialov, A.V. | Deposit date: | 2022-04-13 | Release date: | 2022-08-03 | Last modified: | 2022-09-21 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Archaic chaperone-usher pili self-secrete into superelastic zigzag springs. Nature, 609, 2022
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7AK9
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![BU of 7ak9 by Molmil](/molmil-images/mine/7ak9) | Structure of Salmonella TacT3 toxin bound to TacA3 antitoxin C-terminal peptide | Descriptor: | ABC transporter, Acetyltransferase, DEPHOSPHO COENZYME A | Authors: | Grabe, G.J, Morgan, R.M.L, Hare, S.A, Helaine, S. | Deposit date: | 2020-09-30 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat.Chem.Biol., 17, 2021
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7AK7
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![BU of 7ak7 by Molmil](/molmil-images/mine/7ak7) | Structure of Salmonella TacT2 toxin bound to TacA2 antitoxin | Descriptor: | ACETYL COENZYME *A, Acetyltransferase, CHLORIDE ION, ... | Authors: | Grabe, G.J, Morgan, R.M.L, Hare, S.A, Helaine, S. | Deposit date: | 2020-09-30 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat.Chem.Biol., 17, 2021
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7AK8
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![BU of 7ak8 by Molmil](/molmil-images/mine/7ak8) | Structure of Salmonella TacT1 toxin bound to TacA1 antitoxin C-terminal peptide | Descriptor: | ACETYL COENZYME *A, GCN5 family acetyltransferase, GLYCEROL, ... | Authors: | Grabe, G.J, Morgan, R.M.L, Helaine, S, Hare, S.A. | Deposit date: | 2020-09-30 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat.Chem.Biol., 17, 2021
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5FVJ
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![BU of 5fvj by Molmil](/molmil-images/mine/5fvj) | Crystal structure of TacT (tRNA acetylating toxin) from Salmonella | Descriptor: | ACETYL COENZYME *A, PUTATIVE ACETYLTRANSFERASE | Authors: | Przydacz, M, Wong, C.T, Cheverton, A.M, Gollan, B, Mylona, A, Helaine, S, Hare, S.A. | Deposit date: | 2016-02-08 | Release date: | 2016-06-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A Salmonella Toxin Promotes Persister Formation Through Acetylation of tRNA. Mol.Cell, 63, 2016
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3ETP
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![BU of 3etp by Molmil](/molmil-images/mine/3etp) | The crystal structure of the ligand-binding domain of the EphB2 receptor at 2.0 A resolution | Descriptor: | Ephrin type-B receptor 2 | Authors: | Goldgur, Y, Paavilainen, S, Nikolov, D.B, Himanen, J.P. | Deposit date: | 2008-10-08 | Release date: | 2008-10-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the ligand-binding domain of the EphB2 receptor at 2 A resolution. Acta Crystallogr.,Sect.F, 65, 2009
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1ZC2
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![BU of 1zc2 by Molmil](/molmil-images/mine/1zc2) | Crystal Structure of plasmid-encoded class C beta-lactamase CMY-2 complexed with citrate molecule | Descriptor: | CITRIC ACID, beta-lactamase class C | Authors: | Bauvois, C, Jacquamet, L, Fieulaine, S, Frere, J.-M, Galleni, M, Ferrer, J.-L. | Deposit date: | 2005-04-10 | Release date: | 2006-04-25 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.09 Å) | Cite: | Crystallographic structure of plasmid-encoded CMY-2 beta-lactamase revealed citrate molecule in the active site. To be Published
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3EKK
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![BU of 3ekk by Molmil](/molmil-images/mine/3ekk) | Insulin receptor kinase complexed with an inhibitor | Descriptor: | 2-[(2-{[1-(N,N-dimethylglycyl)-5-methoxy-1H-indol-6-yl]amino}-7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]-6-fluoro-N-methylbenzamide, Insulin receptor | Authors: | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Sabbatini, P, Shewchuk, L. | Deposit date: | 2008-09-19 | Release date: | 2008-12-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase. Bioorg.Med.Chem.Lett., 19, 2009
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3ELJ
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![BU of 3elj by Molmil](/molmil-images/mine/3elj) | Jnk1 complexed with a bis-anilino-pyrrolopyrimidine inhibitor. | Descriptor: | 2-fluoro-6-{[2-({2-methoxy-4-[(methylsulfonyl)methyl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide, Mitogen-activated protein kinase 8 | Authors: | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Shewchuk, L, Vicentini, G, Mosley, J. | Deposit date: | 2008-09-22 | Release date: | 2008-12-30 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg.Med.Chem.Lett., 19, 2009
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3EKN
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![BU of 3ekn by Molmil](/molmil-images/mine/3ekn) | Insulin receptor kinase complexed with an inhibitor | Descriptor: | 2-fluoro-6-{[2-({2-methoxy-4-[4-(1-methylethyl)piperazin-1-yl]phenyl}amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]amino}benzamide, Insulin receptor | Authors: | Chamberlain, S, Atkins, C, Deanda, F, Dumble, M, Gerding, R, Groy, A, Korenchuk, S, Kumar, R, Lei, H, Mook, R, Moorthy, G, Redman, A, Rowland, J, Shewchuk, L. | Deposit date: | 2008-09-19 | Release date: | 2008-12-30 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Optimization of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity. Bioorg.Med.Chem.Lett., 19, 2009
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6Z9I
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![BU of 6z9i by Molmil](/molmil-images/mine/6z9i) | Escherichia coli D-2-deoxyribose-5-phosphate aldolase - N21K mutant complex with reaction products | Descriptor: | 1,2-ETHANEDIOL, Deoxyribose-phosphate aldolase, GLYCERALDEHYDE-3-PHOSPHATE, ... | Authors: | Paakkonen, J, Hakulinen, N, Rouvinen, J. | Deposit date: | 2020-06-04 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods. Appl.Microbiol.Biotechnol., 104, 2020
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6Z9H
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![BU of 6z9h by Molmil](/molmil-images/mine/6z9h) | Escherichia coli D-2-deoxyribose-5-phosphate aldolase - C47V/G204A/S239D mutant | Descriptor: | 1,2-ETHANEDIOL, Deoxyribose-phosphate aldolase, FORMIC ACID, ... | Authors: | Paakkonen, J, Hakulinen, N, Rouvinen, J. | Deposit date: | 2020-06-04 | Release date: | 2020-11-18 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Substrate specificity of 2-deoxy-D-ribose 5-phosphate aldolase (DERA) assessed by different protein engineering and machine learning methods. Appl.Microbiol.Biotechnol., 104, 2020
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6Z9J
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![BU of 6z9j by Molmil](/molmil-images/mine/6z9j) | |
4CHK
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![BU of 4chk by Molmil](/molmil-images/mine/4chk) | Crystal Structure of the ARF5 oligomerization domain | Descriptor: | AUXIN RESPONSE FACTOR 5 | Authors: | Nanao, M.H, Mazzoleni, M, Thevenon, E, Brunoud, G, Vernoux, T, Parcy, F, Dumas, R. | Deposit date: | 2013-12-03 | Release date: | 2014-04-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structural Basis for Oligomerisation of Auxin Transcriptional Regulators Nat.Commun., 5, 2014
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3ETA
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![BU of 3eta by Molmil](/molmil-images/mine/3eta) | Kinase domain of insulin receptor complexed with a pyrrolo pyridine inhibitor | Descriptor: | 1-(3-{5-[4-(aminomethyl)phenyl]-1H-pyrrolo[2,3-b]pyridin-3-yl}phenyl)-3-(2-phenoxyphenyl)urea, insulin receptor, kinase domain | Authors: | Patnaik, S, Stevens, K, Gerding, R, Deanda, F, Shotwell, B, Tang, J, Hamajima, T, Nakamura, H, Leesnitzer, A, Hassell, A, Shewchuk, L, Kumar, R, Lei, H, Chamberlain, S. | Deposit date: | 2008-10-07 | Release date: | 2009-05-26 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of 3,5-disubstituted-1H-pyrrolo[2,3-b]pyridines as potent inhibitors of the insulin-like growth factor-1 receptor (IGF-1R) tyrosine kinase. Bioorg.Med.Chem.Lett., 19, 2009
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5LN8
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![BU of 5ln8 by Molmil](/molmil-images/mine/5ln8) | Crystal structure of self-complemented MyfA, the major subunit of Myf fimbriae from Yersinia enterocolitica, in complex with galactose | Descriptor: | Fimbrial protein MyfA,Fimbrial protein MyfA, beta-D-galactopyranose | Authors: | Pakharukova, N.A, Roy, S, Rahman, M.M, Tuitilla, M, Zavialov, A.V. | Deposit date: | 2016-08-03 | Release date: | 2016-08-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural basis for Myf and Psa fimbriae-mediated tropism of pathogenic strains of Yersinia for host tissues. Mol.Microbiol., 102, 2016
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