5JSB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5jsb by Molmil](/molmil-images/mine/5jsb) | Crystal structure of Mcl1-inhibitor complex | Descriptor: | Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor | Authors: | Shen, B.W, Stoddard, B.L. | Deposit date: | 2016-05-07 | Release date: | 2016-11-16 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.74 Å) | Cite: | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
|
|
4QPZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qpz by Molmil](/molmil-images/mine/4qpz) | Crystal structure of the formolase FLS_v2 in space group P 21 | Descriptor: | Formolase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | Authors: | Shen, B.W, Siegel, J.B, Stoddard, B.L, Baker, D. | Deposit date: | 2014-06-25 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Computational protein design enables a novel one-carbon assimilation pathway. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4R6J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r6j by Molmil](/molmil-images/mine/4r6j) | |
4R6G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r6g by Molmil](/molmil-images/mine/4r6g) | |
4R5D
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r5d by Molmil](/molmil-images/mine/4r5d) | |
4R58
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r58 by Molmil](/molmil-images/mine/4r58) | |
4R5C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r5c by Molmil](/molmil-images/mine/4r5c) | |
4QQ8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4qq8 by Molmil](/molmil-images/mine/4qq8) | Crystal structure of the formolase FLS in space group P 43 21 2 | Descriptor: | 1,2-ETHANEDIOL, Formolase, MAGNESIUM ION, ... | Authors: | Shen, B.W, Siegel, J.B, Stoddard, B.L. | Deposit date: | 2014-06-26 | Release date: | 2015-03-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.88 Å) | Cite: | Computational protein design enables a novel one-carbon assimilation pathway. Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4R6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4r6f by Molmil](/molmil-images/mine/4r6f) | |
2R7E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2r7e by Molmil](/molmil-images/mine/2r7e) | Crystal Structure Analysis of Coagulation Factor VIII | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, COPPER (II) ION, ... | Authors: | Stoddard, B.L, Shen, B.W. | Deposit date: | 2007-09-07 | Release date: | 2008-04-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | The tertiary structure and domain organization of coagulation factor VIII. Blood, 111, 2008
|
|
1GBN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gbn by Molmil](/molmil-images/mine/1gbn) | HUMAN ORNITHINE AMINOTRANSFERASE COMPLEXED WITH THE NEUROTOXIN GABACULINE | Descriptor: | 3-AMINOBENZOIC ACID, GABACULINE, ORNITHINE AMINOTRANSFERASE, ... | Authors: | Shah, S.A, Shen, B.W, Brunger, A.T. | Deposit date: | 1997-05-29 | Release date: | 1998-06-03 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Human ornithine aminotransferase complexed with L-canaline and gabaculine: structural basis for substrate recognition. Structure, 5, 1997
|
|
3HYI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hyi by Molmil](/molmil-images/mine/3hyi) | Crystal structure of full-length DUF199/WhiA from Thermatoga maritima | Descriptor: | GLYCEROL, Protein DUF199/WhiA, SODIUM ION | Authors: | Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L. | Deposit date: | 2009-06-22 | Release date: | 2009-09-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease Structure, 17, 2009
|
|
3HYJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3hyj by Molmil](/molmil-images/mine/3hyj) | Crystal structure of the N-terminal LAGLIDADG domain of DUF199/WhiA | Descriptor: | CHLORIDE ION, GLYCEROL, Protein DUF199/WhiA, ... | Authors: | Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L. | Deposit date: | 2009-06-22 | Release date: | 2009-09-01 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease. Structure, 17, 2009
|
|
2CAN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2can by Molmil](/molmil-images/mine/2can) | |
3U0S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3u0s by Molmil](/molmil-images/mine/3u0s) | Crystal Structure of an Enzyme Redesigned Through Multiplayer Online Gaming: CE6 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Diisopropyl-fluorophosphatase, GLYCEROL, ... | Authors: | Bale, J.B, Shen, B.W, Stoddard, B.L. | Deposit date: | 2011-09-29 | Release date: | 2012-02-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Increased Diels-Alderase activity through backbone remodeling guided by Foldit players. Nat.Biotechnol., 30, 2012
|
|
1D7P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1d7p by Molmil](/molmil-images/mine/1d7p) | Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A | Descriptor: | COAGULATION FACTOR VIII PRECURSOR, CYSTEINE, GLYCEROL, ... | Authors: | Pratt, K.P, Shen, B.W, Stoddard, B.L. | Deposit date: | 1999-10-19 | Release date: | 1999-12-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature, 402, 1999
|
|
5E63
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e63 by Molmil](/molmil-images/mine/5e63) | K262A mutant of I-SmaMI | Descriptor: | 2-(2-METHOXYETHOXY)ETHANOL, 2-METHOXYETHANOL, DNA (5'-D(P*CP*AP*GP*GP*TP*GP*TP*AP*CP*G)-3'), ... | Authors: | Shen, B, Stoddard, B. | Deposit date: | 2015-10-09 | Release date: | 2016-01-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The Structural Basis of Asymmetry in DNA Binding and Cleavage as Exhibited by the I-SmaMI LAGLIDADG Meganuclease. J.Mol.Biol., 428, 2016
|
|
8EIL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8eil by Molmil](/molmil-images/mine/8eil) | C-Terminal Domain of BrxL from Acinetobacter BREX type I phage restriction system | Descriptor: | MALONIC ACID, Protease Lon-related BREX system protein BrxL, SUCCINIC ACID | Authors: | Doyle, L.A, Stoddard, B.L, Kaiser, B. | Deposit date: | 2022-09-15 | Release date: | 2023-02-22 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure, substrate binding and activity of a unique AAA+ protein: the BrxL phage restriction factor. Nucleic Acids Res., 51, 2023
|
|
6XR2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xr2 by Molmil](/molmil-images/mine/6xr2) | |
6XR1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xr1 by Molmil](/molmil-images/mine/6xr1) | |
4OYD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4oyd by Molmil](/molmil-images/mine/4oyd) | Crystal structure of a computationally designed inhibitor of an Epstein-Barr viral Bcl-2 protein | Descriptor: | 1,2-ETHANEDIOL, Apoptosis regulator BHRF1, Computationally designed Inhibitor | Authors: | Shen, B, Procko, E, Baker, D, Stoddard, B. | Deposit date: | 2014-02-11 | Release date: | 2014-07-09 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A computationally designed inhibitor of an epstein-barr viral bcl-2 protein induces apoptosis in infected cells. Cell, 157, 2014
|
|
3UVF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3uvf by Molmil](/molmil-images/mine/3uvf) | Expanding LAGALIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Intron-encoded DNA endonuclease I-HjeMI, ... | Authors: | Jacoby, K, Metzger, M, Shen, B, Jarjour, J, Stoddard, B, Scharenberg, A. | Deposit date: | 2011-11-29 | Release date: | 2012-02-29 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Expanding LAGLIDADG endonuclease scaffold diversity by rapidly surveying evolutionary sequence space. Nucleic Acids Res., 40, 2012
|
|
4YIS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yis by Molmil](/molmil-images/mine/4yis) | Crystal Structure of LAGLIDADG Meganuclease I-CpaMI Bound to Uncleaved DNA | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (28-MER), ... | Authors: | Hallinan, J.P, Kaiser, B.K, Stoddard, B.L. | Deposit date: | 2015-03-02 | Release date: | 2016-03-23 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Indirect DNA Sequence Recognition and Its Impact on Nuclease Cleavage Activity. Structure, 24, 2016
|
|
4YIT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yit by Molmil](/molmil-images/mine/4yit) | |
4YHX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yhx by Molmil](/molmil-images/mine/4yhx) | |