2IBB
 
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1N8Z
 | | Crystal structure of extracellular domain of human HER2 complexed with Herceptin Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Herceptin Fab (antibody) - heavy chain, Herceptin Fab (antibody) - light chain, ... | | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | | Deposit date: | 2002-11-21 | | Release date: | 2003-02-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.52 Å) | | Cite: | Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab
Nature, 421, 2003
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1OT8
 | | Structure of the Ankyrin Domain of the Drosophila Notch Receptor | | Descriptor: | MAGNESIUM ION, Neurogenic locus Notch protein | | Authors: | Zweifel, M.E, Leahy, D.J, Hughson, F.M, Barrick, D. | | Deposit date: | 2003-03-21 | | Release date: | 2003-10-28 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure and stability of the ankyrin domain of the Drosophila Notch receptor
Protein Sci., 12, 2003
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1N8Y
 | | Crystal structure of the extracellular region of rat HER2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, protooncoprotein | | Authors: | Cho, H.-S, Mason, K, Ramyar, K.X, Stanley, A.M, Gabelli, S.B, Denney Jr, D.W, Leahy, D.J. | | Deposit date: | 2002-11-21 | | Release date: | 2003-02-18 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of the Extracellular Region of HER2 Alone and in complex with the Herceptin Fab
Nature, 421, 2003
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1YN4
 | | Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens | | Descriptor: | EapH1, ZINC ION | | Authors: | Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J. | | Deposit date: | 2005-01-23 | | Release date: | 2005-03-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
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1YN5
 | | Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens | | Descriptor: | EapH2 | | Authors: | Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J. | | Deposit date: | 2005-01-23 | | Release date: | 2005-03-01 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
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1YN3
 | | Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens | | Descriptor: | truncated cell surface protein map-w | | Authors: | Geisbrecht, B.V, Hamaoka, B.Y, Perman, B, Zemla, A, Leahy, D.J. | | Deposit date: | 2005-01-23 | | Release date: | 2005-03-01 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | The Crystal Structures of EAP Domains from Staphylococcus aureus Reveal an Unexpected Homology to Bacterial Superantigens.
J.Biol.Chem., 280, 2005
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2A90
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2OGB
 | | Crystal structure of the C-terminal domain of mouse Nrdp1 | | Descriptor: | GLYCEROL, RING finger protein 41, THIOCYANATE ION | | Authors: | Bouyain, S, Leahy, D.J. | | Deposit date: | 2007-01-05 | | Release date: | 2007-01-16 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Structure-based mutagenesis of the substrate-recognition domain of Nrdp1/FLRF identifies the binding site for the receptor tyrosine kinase ErbB3.
Protein Sci., 16, 2007
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2ORX
 | | Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | | Descriptor: | Neuropilin-1 | | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | | Deposit date: | 2007-02-05 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains
Proc.Natl.Acad.Sci.Usa, 104, 2007
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2ORZ
 | | Structural Basis for Ligand Binding and Heparin Mediated Activation of Neuropilin | | Descriptor: | Neuropilin-1, Tuftsin | | Authors: | Vander Kooi, C.W, Jusino, M.A, Perman, B, Neau, D.B, Bellamy, H.D, Leahy, D.J. | | Deposit date: | 2007-02-05 | | Release date: | 2007-04-03 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural basis for ligand and heparin binding to neuropilin B domains.
Proc.Natl.Acad.Sci.Usa, 104, 2007
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1IJX
 | | CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF SECRETED FRIZZLED-RELATED PROTEIN 3 (SFRP-3;FZB) | | Descriptor: | SECRETED FRIZZLED-RELATED SEQUENCE PROTEIN 3, SULFATE ION | | Authors: | Dann III, C.E, Hsieh, J.C, Rattner, A, Sharma, D, Nathans, J, Leahy, D.J. | | Deposit date: | 2001-04-30 | | Release date: | 2001-07-11 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Nature, 412, 2001
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1IJY
 | | CRYSTAL STRUCTURE OF THE CYSTEINE-RICH DOMAIN OF MOUSE FRIZZLED 8 (MFZ8) | | Descriptor: | FRIZZLED HOMOLOG 8 | | Authors: | Dann III, C.E, Hsieh, J.C, Rattner, A, Sharma, D, Nathans, J, Leahy, D.J. | | Deposit date: | 2001-05-01 | | Release date: | 2001-07-11 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains.
Nature, 412, 2001
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3ODN
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3N1G
 | | Crystal structure of DhhN bound to BOCFn3 | | Descriptor: | Brother of CDO, CALCIUM ION, Desert hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-15 | | Release date: | 2010-06-02 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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3N1R
 | | Crystal Structure of ShhN | | Descriptor: | CALCIUM ION, Sonic hedgehog protein, ZINC ION | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Crystal Structure of ShhN
TO BE PUBLISHED
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3N1P
 | | Crystal Structure of IhhN bound to BOCFn3 | | Descriptor: | Brother of CDO, CALCIUM ION, Indian hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2010-06-02 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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3N1Q
 | | Crystal Structure of DhhN bound to CDOFn3 | | Descriptor: | CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Desert hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2010-06-02 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.89 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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3N1F
 | | Crystal Structure of IhhN bound to CDOFn3 | | Descriptor: | CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Indian hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-15 | | Release date: | 2010-06-02 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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3N1M
 | | Crystal Structure of IhhN bound to BOCFn3 | | Descriptor: | Brother of CDO, CALCIUM ION, Indian hedgehog protein, ... | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-15 | | Release date: | 2010-06-02 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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3N1O
 | | Crystal structure of IhhN | | Descriptor: | CALCIUM ION, Indian hedgehog protein, ZINC ION | | Authors: | Kavran, J.M, Leahy, D.J. | | Deposit date: | 2010-05-16 | | Release date: | 2010-06-02 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner.
J.Biol.Chem., 285, 2010
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1SZH
 | | Crystal Structure of C. elegans HER-1 | | Descriptor: | ACETATE ION, Her-1 protein | | Authors: | Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J. | | Deposit date: | 2004-04-05 | | Release date: | 2004-08-10 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Proc.Natl.Acad.Sci.USA, 101, 2004
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1AT0
 | | 17-kDA fragment of hedgehog C-terminal autoprocessing domain | | Descriptor: | 17-HEDGEHOG | | Authors: | Hall, T.M.T, Porter, J.A, Young, K.E, Koonin, E.V, Beachy, P.A, Leahy, D.J. | | Deposit date: | 1997-08-15 | | Release date: | 1997-11-12 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins.
Cell(Cambridge,Mass.), 91, 1997
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1VHH
 | | A POTENTIAL CATALYTIC SITE WITHIN THE AMINO-TERMINAL SIGNALLING DOMAIN OF SONIC HEDGEHOG | | Descriptor: | SONIC HEDGEHOG, SULFATE ION, ZINC ION | | Authors: | Hall, T.M.T, Porter, J.A, Beachy, P.A, Leahy, D.J. | | Deposit date: | 1995-10-03 | | Release date: | 1996-01-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog.
Nature, 378, 1995
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4X3X
 | | The crystal structure of Arc C-lobe | | Descriptor: | Activity-regulated cytoskeleton-associated protein | | Authors: | Zhang, W, Ward, M, Leahy, D, Worley, P. | | Deposit date: | 2014-12-01 | | Release date: | 2015-06-03 | | Last modified: | 2017-09-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of arc binding to synaptic proteins: implications for cognitive disease.
Neuron, 86, 2015
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