8KBK
 
 | | Structure of AcrIIA7 complexed with 1',2'-cADPR and cGG | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.28 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBD
 | | Structure of CmTad1 complexed with cAAG | | Descriptor: | Thoeris anti-defense 1, ZINC ION, cAAG | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (3.15 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBI
 | | Structure of apo-AcrIIA7 | | Descriptor: | Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBM
 | | Structure of AcrIIA7 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-07 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.38 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBJ
 | | Structure of HgmTad2 complexed with 1',2'-cADPR | | Descriptor: | (1S,3R,4R,6R,9S,11R,14R,15S,16R,18R)-4-(6-amino-9H-purin-9-yl)-9,11,15,16,18-pentahydroxy-2,5,8,10,12,17-hexaoxa-9lambda~5~,11lambda~5~-diphosphatricyclo[12.2.1.1~3,6~]octadecane-9,11-dione, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBG
 | | Structure of CbTad1 complexed with 2',3'-cGAMP | | Descriptor: | Thoeris anti-defense 1, cGAMP | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBC
 | | Structure of CmTad1 complexed with cAAA | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, Thoeris anti-defense 1, ZINC ION | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8KBH
 | | Structure of CbTad1 complexed with 2',3'-cGAMP and cA3 | | Descriptor: | (2-ACETYL-5-METHYLANILINO)(2,6-DIBROMOPHENYL)ACETAMIDE, Thoeris anti-defense 1, cGAMP | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-08-04 | | Release date: | 2024-08-21 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.54 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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7YPE
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7YPF
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7XXJ
 | | Echo 18 incubated with FcRn at pH5.5 | | Descriptor: | PALMITIC ACID, VP1, VP2, ... | | Authors: | Liu, C.C, Qu, X. | | Deposit date: | 2022-05-30 | | Release date: | 2022-06-29 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.33 Å) | | Cite: | Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Mbio, 13, 2022
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7XXA
 | | Complex of Echo 18 and FcRn at pH7.4 | | Descriptor: | IgG receptor FcRn large subunit p51, VP1, VP2, ... | | Authors: | Liu, C.C, Qu, X. | | Deposit date: | 2022-05-29 | | Release date: | 2022-06-29 | | Last modified: | 2024-07-03 | | Method: | ELECTRON MICROSCOPY (3.09 Å) | | Cite: | Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Mbio, 13, 2022
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7XXG
 | | Echo 18 at pH5.5 | | Descriptor: | PALMITIC ACID, VP1, VP2, ... | | Authors: | Liu, C.C, Qu, X. | | Deposit date: | 2022-05-30 | | Release date: | 2022-06-29 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.37 Å) | | Cite: | Human FcRn Is a Two-in-One Attachment-Uncoating Receptor for Echovirus 18.
Mbio, 13, 2022
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8WJE
 | | Structure of apo-SPO1 Tad2 | | Descriptor: | Gp34.65 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8WJD
 | | Structure of SptTad2 complexed with cGG | | Descriptor: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), SptTad2 | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (1.71 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8WJC
 | | Structure of AcrIIA7 complexed with 3'3'-cGAMP | | Descriptor: | 2-amino-9-[(2R,3R,3aS,5R,7aR,9R,10R,10aS,12R,14aR)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Inhibitor of Type II CRISPR-Cas system | | Authors: | Xiao, Y, Feng, Y. | | Deposit date: | 2023-09-25 | | Release date: | 2024-09-25 | | Last modified: | 2024-12-04 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Single phage proteins sequester signals from TIR and cGAS-like enzymes.
Nature, 635, 2024
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8GJT
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-116-D1 | | Descriptor: | (3S)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Tolbert, W.D, Nguyen, D.N, Pazgier, M. | | Deposit date: | 2023-03-16 | | Release date: | 2023-06-07 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GD0
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with TFH-I-070-A6 | | Descriptor: | (3S)-N-(4-chloro-3-fluorophenyl)-1-(4-methylpiperazine-1-carbonyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Tolbert, W.D, Nguyen, D.N, Pazgier, M. | | Deposit date: | 2023-03-03 | | Release date: | 2023-06-07 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GCZ
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with ZXC-I-090 | | Descriptor: | (3S,5S)-5-(aminomethyl)-N-(4-chloro-3-fluorophenyl)-1-(4-methylpiperazine-1-carbonyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Nguyen, D.N, Tolbert, W.D, Pazgier, M. | | Deposit date: | 2023-03-03 | | Release date: | 2023-06-07 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GD1
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with ZXC-I-092 | | Descriptor: | (3S,5S)-5-(aminomethyl)-N-(4-chloro-3-fluorophenyl)-1-[(3R,5S)-3,4,5-trimethylpiperazine-1-carbonyl]piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Tolbert, W.D, Nguyen, D.N, Pazgier, M. | | Deposit date: | 2023-03-03 | | Release date: | 2023-06-07 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GD5
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with DL-I-102 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HIV-1 LM/HS clade A/E CRF01 gp120 core, ... | | Authors: | Tolbert, W.D, Nguyen, D.N, Pazgier, M. | | Deposit date: | 2023-03-03 | | Release date: | 2023-06-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GD3
 | | Crystal Structure of HIV-1 LM/HT Clade A/E CRF01 GP120 Core in Complex with DL-I-101 | | Descriptor: | (3S,5R)-N-(4-chloro-3-fluorophenyl)-1-(4-glycylpiperazine-1-carbonyl)-5-(hydroxymethyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Tolbert, W.D, Nguyen, D.N, Pazgier, M. | | Deposit date: | 2023-03-03 | | Release date: | 2023-06-07 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Piperidine CD4-Mimetic Compounds Expose Vulnerable Env Epitopes Sensitizing HIV-1-Infected Cells to ADCC.
Viruses, 15, 2023
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8GZJ
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8GZL
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8GZM
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