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1E9W
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BU of 1e9w by Molmil
Structure of the macrocycle thiostrepton solved using the anomalous dispersive contribution from sulfur
Descriptor: THIOSTREPTON
Authors:Bond, C.S, Shaw, M.P, Alphey, M.S, Hunter, W.N.
Deposit date:2000-10-27
Release date:2001-03-23
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.02 Å)
Cite:Structure of the Macrocycle Thiostrepton Solved Using the Anomalous Dispersive Contribution from Sulfur
Acta Crystallogr.,Sect.D, 57, 2001
1E2Y
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BU of 1e2y by Molmil
Tryparedoxin peroxidase from Crithidia fasciculata
Descriptor: CHLORIDE ION, TRYPAREDOXIN PEROXIDASE
Authors:Alphey, M.S, Bond, C.S, Hunter, W.N.
Deposit date:2000-05-30
Release date:2001-03-23
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The Structure of Reduced Tryparedoxin Peroxidase Reveals a Decamer and Insight Into Reactivity of 2Cys-Peroxiredoxins
J.Mol.Biol., 300, 2000
1GUT
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BU of 1gut by Molmil
MopII from Clostridium pasteurianum (apo2)
Descriptor: CHLORIDE ION, MAGNESIUM ION, MOLYBDATE BINDING PROTEIN II
Authors:Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N.
Deposit date:2002-01-28
Release date:2002-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
1H9S
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BU of 1h9s by Molmil
Molybdate bound complex of Dimop domain of ModE from E.coli
Descriptor: MOLYBDATE ION, MOLYBDENUM TRANSPORT PROTEIN MODE
Authors:Gourley, D.G, Hunter, W.N.
Deposit date:2001-03-19
Release date:2001-06-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Oxyanion Binding Alters Conformational and Quaternary Structure of the C-Terminal Domain of the Transcriptional Regulator Mode; Implications for Molybdate-Dependant Regulation, Signalling, Storage and Transport
J.Biol.Chem., 276, 2001
1GX1
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BU of 1gx1 by Molmil
Structure of 2C-Methyl-D-erythritol-2,4-cyclodiphosphate Synthase
Descriptor: 2-C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-DIPHOSPHATE, MANGANESE (II) ION, ...
Authors:Kemp, L.E, Bond, C.S, Hunter, W.N.
Deposit date:2002-03-26
Release date:2002-04-03
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of 2C-Methyl-D-Erythritol 2,4-Cyclodiphosphate Synthase: An Essential Enzyme for Isoprenoid Biosynthesis and Target for Antimicrobial Drug Development
Proc.Natl.Acad.Sci.USA, 99, 2002
1H48
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BU of 1h48 by Molmil
The structure of 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase in complex with CMP and product
Descriptor: 2C-METHYL-D-ERYTHRITOL 2,4-CYCLODIPHOSPHATE, 2C-METHYL-D-ERYTHRITOL-2,4-CYCLODIPHOSPHATE SYNTHASE, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Kemp, L.E, Alphey, M.S, Bond, C.S, Hunter, W.N.
Deposit date:2003-02-24
Release date:2004-12-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Identification of Isoprenoids that Bind in the Intersubunit Cavity of Escherichia Coli 2C-Methyl-D-Erythritol-2,4-Cyclodiphosphate Synthase by Complementary Biophysical Methods
Acta Crystallogr.,Sect.D, 61, 2005
1H9R
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BU of 1h9r by Molmil
Tungstate bound complex Dimop domain of ModE from E.coli
Descriptor: MOLYBDENUM TRANSPORT PROTEIN MODE, NICKEL (II) ION, TUNGSTATE(VI)ION
Authors:Gourley, D.G, Hunter, W.N.
Deposit date:2001-03-19
Release date:2001-06-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Oxyanion Binding Alters Conformational and Quaternary Structure of the C-Terminal Domain of the Transcriptional Regulator Mode; Implications for Molybdate-Dependant Regulation, Signalling, Storage and Transport
J.Biol.Chem., 276, 2001
1H3M
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BU of 1h3m by Molmil
Structure of 4-diphosphocytidyl-2C-methyl-D-erythritol synthetase
Descriptor: 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLORIDE ION, PENTANE-1,5-DIAMINE
Authors:Kemp, L.E, Bond, C.S, Hunter, W.N.
Deposit date:2002-09-10
Release date:2003-08-01
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Tetragonal Crystal Form of Escherichia Coli 2-C-Methyl-D-Erythritol 4-Phosphate Cytidylyltransferase
Acta Crystallogr.,Sect.D, 59, 2003
1GUO
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BU of 1guo by Molmil
MopII from Clostridium pasteurianum complexed with molybdate
Descriptor: MOLYBDATE BINDING PROTEIN II, MOLYBDATE ION
Authors:Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N.
Deposit date:2002-01-28
Release date:2002-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
1GYN
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BU of 1gyn by Molmil
Class II fructose 1,6-bisphosphate aldolase with Cadmium (not Zinc) in the active site
Descriptor: CADMIUM ION, FRUCTOSE-BISPHOSPHATE ALDOLASE II
Authors:Hall, D.R, Kemp, L.E, Leonard, G.A, Berry, A, Hunter, W.N.
Deposit date:2002-04-27
Release date:2003-02-26
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Organization of Divalent Cations in the Active Site of Cadmium Escherichia Coli Fructose 1,6-Bisphosphate Aldolase
Acta Crystallogr.,Sect.D, 59, 2003
1GUS
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BU of 1gus by Molmil
MopII from Clostridium pasteurianum (apo1)
Descriptor: CHLORIDE ION, MAGNESIUM ION, MOLYBDATE BINDING PROTEIN II
Authors:Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N.
Deposit date:2002-01-28
Release date:2002-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
1GY8
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BU of 1gy8 by Molmil
Trypanosoma brucei UDP-galactose 4' epimerase
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, UDP-GALACTOSE 4-EPIMERASE, URIDINE-5'-DIPHOSPHATE
Authors:Shaw, M.P, Bond, C.S, Hunter, W.N.
Deposit date:2002-04-21
Release date:2003-05-22
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:High-Resolution Crystal Structure of Trypanosoma Brucei Udp-Galactose 4'-Epimerase: A Potential Target for Structure-Based Development of Novel Trypanocides
Mol.Biochem.Parasitol., 126, 2003
1GXF
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BU of 1gxf by Molmil
CRYSTAL STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN COMPLEX WITH THE INHIBITOR QUINACRINE MUSTARD
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, MALEIC ACID, QUINACRINE MUSTARD, ...
Authors:Bond, C.S, Peterson, M.R, Vickers, T.J, Fairlamb, A.H, Hunter, W.N.
Deposit date:2002-04-04
Release date:2004-05-06
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Two Interacting Binding Sites for Quinacrine Derivatives in the Active Site of Trypanothione Reductase: A Template for Drug Design
J.Biol.Chem., 279, 2004
1GUN
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BU of 1gun by Molmil
MopII from Clostridium pasteurianum complexed with molybdate (partial)
Descriptor: CALCIUM ION, MOLYBDATE BINDING PROTEIN II, MOLYBDATE ION
Authors:Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N.
Deposit date:2002-01-28
Release date:2002-02-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
1E92
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BU of 1e92 by Molmil
Pteridine reductase 1 from Leishmania major complexed with NADP+ and dihydrobiopterin
Descriptor: 1,2-ETHANEDIOL, 7,8-DIHYDROBIOPTERIN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Schuettelkopf, A.W, Hunter, W.N.
Deposit date:2000-10-04
Release date:2001-10-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites
Nat.Struct.Biol., 8, 2001
1GVF
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BU of 1gvf by Molmil
Structure of tagatose-1,6-bisphosphate aldolase
Descriptor: 1,2-ETHANEDIOL, PHOSPHOGLYCOLOHYDROXAMIC ACID, SODIUM ION, ...
Authors:Hall, D.R, Hunter, W.N.
Deposit date:2002-02-11
Release date:2002-06-18
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of Tagatose-1,6-Bisphosphate Aldolase; Insight Into Chiral Discrimination, Mechanism and Specificity of Class II Aldolases
J.Biol.Chem., 277, 2002
1GUG
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BU of 1gug by Molmil
MopII from Clostridium pasteurianum complexed with tungstate
Descriptor: CHLORIDE ION, MOLYBDATE BINDING PROTEIN II, SODIUM ION, ...
Authors:Schuettelkopf, A.W, Harrison, J.A, Hunter, W.N.
Deposit date:2002-01-25
Release date:2002-02-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Passive Acquisition of Ligand by the Mopii Molbindin from Clostridium Pasteurianum: Structures of Apo and Oxyanion-Bound Forms
J.Biol.Chem., 277, 2002
1HH1
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BU of 1hh1 by Molmil
THE STRUCTURE OF HJC, A HOLLIDAY JUNCTION RESOLVING ENZYME FROM SULFOLOBUS SOLFATARICUS
Descriptor: HOLLIDAY JUNCTION RESOLVING ENZYME HJC
Authors:Bond, C.S, Kvaratskhelia, M, Richard, D, White, M.F, Hunter, W.N.
Deposit date:2000-12-18
Release date:2001-04-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure of Hjc, a Holliday Junction Resolvase, from Sulfolobus Solfataricus
Proc.Natl.Acad.Sci.USA, 98, 2001
1E7W
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BU of 1e7w by Molmil
One active site, two modes of reduction correlate the mechanism of leishmania pteridine reductase with pterin metabolism and antifolate drug resistance in trpanosomes
Descriptor: 1,2-ETHANEDIOL, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Gourley, D.G, Hunter, W.N.
Deposit date:2000-09-11
Release date:2001-09-06
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Pteridine Reductase Mechanism Correlates Pterin Metabolism with Drug Resistance in Trypanosomatid Parasites.
Nat.Struct.Biol., 8, 2001
1E58
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BU of 1e58 by Molmil
E.coli cofactor-dependent phosphoglycerate mutase
Descriptor: CHLORIDE ION, PHOSPHOGLYCERATE MUTASE, SULFATE ION
Authors:Bond, C.S, Hunter, W.N.
Deposit date:2000-07-19
Release date:2001-03-20
Last modified:2019-05-22
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:High Resolution Structure of the Phosphohistidine-Activated Form of Escherichia Coli Cofactor-Dependent Phosphoglycerate Mutase.
J.Biol.Chem., 276, 2001
1E59
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BU of 1e59 by Molmil
E.coli cofactor-dependent phosphoglycerate mutase complexed with vanadate
Descriptor: CHLORIDE ION, PHOSPHOGLYCERATE MUTASE, TETRAMETAVANADATE
Authors:Bond, C.S, Hunter, W.N.
Deposit date:2000-07-19
Release date:2002-02-05
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Mechanistic Implications for Escherichia Coli Cofactor-Dependent Phosphoglycerate Mutase Based on the High-Resolution Crystal Structure of a Vanadate Complex.
J.Mol.Biol., 316, 2002
4CQI
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BU of 4cqi by Molmil
Crystal structure of recombinant tubulin-binding cofactor A (TBCA) from Leishmania major
Descriptor: GLYCEROL, SULFATE ION, TUBULIN-BINDING COFACTOR A
Authors:Barrack, K.L, Fyfe, P.K, Hunter, W.N.
Deposit date:2014-02-17
Release date:2014-11-26
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Structure of Tubulin-Binding Cofactor a from Leishmania Major Infers a Mode of Association During the Early Stages of Microtubule Assembly
Acta Crystallogr.,Sect.F, 71, 2015
4CM3
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BU of 4cm3 by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 5-phenyl-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, ...
Authors:Barrack, K.L, Hunter, W.N.
Deposit date:2014-01-15
Release date:2015-01-21
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014
4C9Z
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BU of 4c9z by Molmil
Crystal structure of Siah1 at 1.95 A resolution
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE SIAH1, ...
Authors:Rimsa, V, Eadsforth, T.C, Hunter, W.N.
Deposit date:2013-10-04
Release date:2013-10-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Two High-Resolution Structures of the Human E3 Ubiquitin Ligase Siah1.
Acta Crystallogr.,Sect.F, 96, 2013
4CMG
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BU of 4cmg by Molmil
Crystal structure of pteridine reductase 1 (PTR1) from Trypanosoma brucei in ternary complex with cofactor and inhibitor
Descriptor: 6-(4-fluorophenyl)-5-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine, ACETATE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Barrack, K.L, Hunter, W.N.
Deposit date:2014-01-16
Release date:2015-01-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1.
J.Med.Chem., 57, 2014

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