1YWT
| Crystal structure of the human sigma isoform of 14-3-3 in complex with a mode-1 phosphopeptide | 分子名称: | 14-3-3 protein sigma, CALCIUM ION, synthetic optimal phosphopeptide (mode-1) | 著者 | Wilker, E.W, Grant, R.A, Artim, S.C, Yaffe, M.B. | 登録日 | 2005-02-18 | 公開日 | 2005-03-01 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A structural basis for 14-3-3sigma functional specificity. J.Biol.Chem., 280, 2005
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8VEY
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8VEU
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8VET
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8VEX
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8VEW
| Crystal structure of PRMT5:MEP50 in complex with MTA and oxamide compound 24 | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, 5-{2-[(2R,5S)-5-methyl-2-phenylpiperidin-1-yl](oxo)acetamido}pyridine-3-carboxamide, CHLORIDE ION, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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8VEO
| Crystal structure of PRMT5:MEP50 in complex with MTA | 分子名称: | 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Whittington, D.A. | 登録日 | 2023-12-20 | 公開日 | 2024-04-24 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Discovery of TNG908: A Selective, Brain Penetrant, MTA-Cooperative PRMT5 Inhibitor That Is Synthetically Lethal with MTAP -Deleted Cancers. J.Med.Chem., 67, 2024
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