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6EQ2
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BU of 6eq2 by Molmil
MTH1 in complex with fragment 6
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.802 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ7
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BU of 6eq7 by Molmil
MTH1 in complex with fragment 11
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, 7-(3-fluoranylpyridin-4-yl)-1~{H}-imidazo[4,5-b]pyridin-2-amine, SULFATE ION
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ3
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BU of 6eq3 by Molmil
MTH1 in complex with fragment 9
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [2-(1~{H}-pyrrolo[2,3-b]pyridin-4-yl)-1,3-thiazol-4-yl]methanol
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.798 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ5
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BU of 6eq5 by Molmil
MTH1 in complex with fragment 4
分子名称: 1H-benzimidazol-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.801 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ4
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BU of 6eq4 by Molmil
MTH1 in complex with fragment 8
分子名称: 4-(3-fluoranylpyridin-4-yl)-1~{H}-pyrrolo[2,3-b]pyridine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
6EQ6
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BU of 6eq6 by Molmil
MTH1 in complex with fragment 1
分子名称: 3-pyrrolidin-1-ylquinoxalin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Wiedmer, L, Sledz, P, Caflisch, A.
登録日2017-10-12
公開日2018-10-31
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Ligand retargeting by binding site analogy.
Eur.J.Med.Chem., 175, 2019
5EWW
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BU of 5eww by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED21
分子名称: NITRATE ION, Peregrin, ~{N}-[(2~{R})-butan-2-yl]-1-methyl-[1,2,4]triazolo[4,3-a]quinoxalin-4-amine
著者Zhu, J, Wiedmer, L, Caflisch, A.
登録日2015-11-21
公開日2016-11-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Crystal structure of the human BRPF1 bromodomain in complex with SEED21
To Be Published
5EWV
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BU of 5ewv by Molmil
Crystal structure of the human BRPF1 bromodomain in complex with SEED20
分子名称: 1,5-dimethyl-[1,2,4]triazolo[4,3-a]quinoline, NITRATE ION, Peregrin
著者Zhu, J, Wiedmer, L, Caflisch, A.
登録日2015-11-21
公開日2016-11-02
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.67 Å)
主引用文献Crystal structure of the human BRPF1 bromodomain in complex with SEED20
To Be Published
6YL0
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BU of 6yl0 by Molmil
Crystal structure of YTHDC1 with compound T_96
分子名称: DI(HYDROXYETHYL)ETHER, SULFATE ION, YTHDC1, ...
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-06
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of YTHDC1 with compound T_96
To Be Published
6YNN
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BU of 6ynn by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_135
分子名称: 6-[[(2-chloranyl-6-fluoranyl-phenyl)methyl-methyl-amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6YNO
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BU of 6yno by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_139
分子名称: 6-[[methyl-[(1-phenylpyrazol-3-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-04-14
公開日2020-07-15
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6YM2
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BU of 6ym2 by Molmil
Crystal structure of YTHDC1 with compound ADO_AC_25
分子名称: SULFATE ION, YTHDC1, ~{N},9-dimethylpurin-6-amine
著者Bedi, R.K, Li, Y, Dolbois, A, Wiedmer, L, Caflisch, A.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of YTHDC1 with compound ADO_AC_25
To Be Published
6YM8
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BU of 6ym8 by Molmil
Crystal structure of YTHDC1 with compound YLI_DC1_002
分子名称: 2-chloranyl-~{N}-methyl-9~{H}-purin-6-amine, SULFATE ION, YTHDC1
著者Bedi, R.K, Li, Y, Wiedmer, L, Caflisch, A.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Crystal structure of YTHDC1 with compound YLI_DC1_002
To Be Published
6ZCN
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BU of 6zcn by Molmil
Crystal structure of YTHDC1 with m6A
分子名称: N6-METHYLADENOSINE-5'-MONOPHOSPHATE, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-06-11
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6ZCM
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BU of 6zcm by Molmil
Crystal structure of YTHDC1 with compound DHU_DC1_180
分子名称: 6-[[cyclopropyl-[(7-methoxy-1,3-benzodioxol-5-yl)methyl]amino]methyl]-1~{H}-pyrimidine-2,4-dione, SULFATE ION, YTHDC1
著者Bedi, R.K, Huang, D, Wiedmer, L, Caflisch, A.
登録日2020-06-11
公開日2020-07-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m 6 A) Recognition by the Reader Domain of YTHDC1.
J Chem Theory Comput, 17, 2021
6SW3
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BU of 6sw3 by Molmil
Crystal structure of CREBBP bromodomain L1109W mutant
分子名称: cDNA FLJ57039, highly similar to CREB-binding protein
著者Faessler, C, Bedi, R.K, Wiedmer, L, Caflisch, A.
登録日2019-09-19
公開日2019-10-16
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Crystal structure of CREBBP bromodomain L1109W mutant
To Be Published
6GLU
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BU of 6glu by Molmil
Crystal structure of hMTH1 D120N in complex with LW14 in the presence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献hMTH1 D120N in complex with LW14
To Be Published
6GLF
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BU of 6glf by Molmil
Crystal structure of hMTH1 F27A in the presence of acetate
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献hMTH1 F27A
To Be Published
6GLL
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BU of 6gll by Molmil
Crystal structure of hMTH1 N33A in complex with LW14 in the presence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.395 Å)
主引用文献hMTH1 N33A in complex with LW14
To Be Published
6GLE
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BU of 6gle by Molmil
Crystal structure of hMTH1 in complex with TH scaffold 1 in the presence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.402 Å)
主引用文献hMTH1 in complex with TH scaffold 1
To Be Published
6GLK
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BU of 6glk by Molmil
Crystal structure of hMTH1 N33A in the presence of acetate
分子名称: 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献in progress
To Be Published
6GLR
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BU of 6glr by Molmil
Crystal structure of hMTH1 N33G in complex with TH scaffold 1 in the presence of acetate
分子名称: 4-phenylpyrimidin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献hMTH1 N33G in complex with TH scaffold 1
To Be Published
6GLQ
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BU of 6glq by Molmil
Crystal structure of hMTH1 N33G in complex with LW14 in the absence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
実験手法X-RAY DIFFRACTION (1.601 Å)
主引用文献hMTH1 N33G in complex with LW14.
To Be Published
6GLG
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BU of 6glg by Molmil
Crystal structure of hMTH1 F27A in complex with LW14 in the presence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ...
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.313 Å)
主引用文献hMTH1 F27A in complex with LW14
To Be Published
6GLM
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BU of 6glm by Molmil
Crystal structure of hMTH1 N33A in complex with LW14 in the absence of acetate
分子名称: 1~{H}-imidazo[4,5-b]pyridin-2-amine, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION
著者Eberle, S.A, Wiedmer, L, Sledz, P, Caflisch, A.
登録日2018-05-23
公開日2019-02-20
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献hMTH1 N33A in complex with LW14
To Be Published

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