5JQA
 
 | | CaM:RM20 complex | | 分子名称: | CALCIUM ION, Calmodulin, Myosin light chain kinase, ... | | 著者 | Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2016-05-04 | | 公開日 | 2017-10-11 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | CaM:RM20 complex
To be Published
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4YO4
 | | Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment phthalazine | | 分子名称: | ACETATE ION, CHLORIDE ION, Death-associated protein kinase 1, ... | | 著者 | Grum-Tokars, V.L, Roy, S.M, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2015-03-11 | | 公開日 | 2015-05-06 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Crystal Structure of DAPK1 catalytic domain in complex with hinge binding fragments
To Be Published
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4YPD
 | | Crystal Structure of DAPK1 catalytic domain in complex with the hinge binding fragment 4-methylpyridazine | | 分子名称: | 4-methylpyridazine, CHLORIDE ION, Death-associated protein kinase 1, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Roy, S.M, Anderson, W.F, Watterson, D.M. | | 登録日 | 2015-03-12 | | 公開日 | 2015-05-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Crystal Structure of DAPK1 catalytic domain in complex with hinge binding fragments
To Be Published
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4R3C
 | | Crystal structure of p38 alpha MAP kinase in complex with a novel isoform selective drug candidate | | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine, CHLORIDE ION, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Roy, S.M, Anderson, W.F, Watterson, D.M. | | 登録日 | 2014-08-14 | | 公開日 | 2015-02-25 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Targeting human central nervous system protein kinases: An isoform selective p38 alpha MAPK inhibitor that attenuates disease progression in Alzheimer's disease mouse models.
ACS Chem Neurosci, 6, 2015
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5JTH
 | | Crystal structure of E67A calmodulin - CaM:RM20 analog complex | | 分子名称: | CALCIUM ION, Calmodulin, Myosin light chain kinase, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2016-05-09 | | 公開日 | 2017-07-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | | 主引用文献 | Crystal structure of E67A calmodulin - CaM:RM20 analog complex
To Be Published
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4F9W
 | | Human P38alpha MAPK in Complex with a Novel and Selective Small Molecule Inhibitor | | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, ACETATE ION, BETA-MERCAPTOETHANOL, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2012-05-21 | | 公開日 | 2013-06-05 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
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4FA2
 | | Human P38 alpha Mitogen-Activated Kinase In Complex With SB239063 | | 分子名称: | 1,2-ETHANEDIOL, 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, BETA-MERCAPTOETHANOL, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2012-05-21 | | 公開日 | 2013-06-05 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
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4F9Y
 | | Human P38 alpha MAPK In Complex With a Novel and Selective Small Molecule Inhibitor | | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Grum-Tokars, V.L, Minasov, G, Anderson, W.F, Watterson, D.M. | | 登録日 | 2012-05-21 | | 公開日 | 2013-06-05 | | 最終更新日 | 2020-01-01 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction.
Plos One, 8, 2013
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7V01
 | | Staphylococcus epidermidis RP62a CRISPR short effector complex with self RNA target and ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7UZY
 | | Staphylococcus epidermidis RP62A CRISPR effector complex with non-self target RNA 2 | | 分子名称: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (4.05 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7V02
 | | Staphylococcus epidermidis RP62A CRISPR short effector complex | | 分子名称: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (4.97 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7UZZ
 | | Staphylococcus epidermidis RP62a CRISPR tall effector complex | | 分子名称: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, CRISPR system Cms protein Csm4, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (4.45 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7UZW
 | | Staphylococcus epidermidis RP62a CRISPR effector subcomplex | | 分子名称: | CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm4, CRISPR system single-strand-specific deoxyribonuclease Cas10/Csm1 (subtype III-A), ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.55 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7UZX
 | | Staphylococcus epidermidis RP62a CRISPR effector subcomplex with non-self target RNA bound | | 分子名称: | CRISPR non-self RNA target, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm4, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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7V00
 | | Staphylococcus epidermidis RP62a CRISPR tall effector complex with bound ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CRISPR system Cms endoribonuclease Csm3, CRISPR system Cms protein Csm2, ... | | 著者 | Smith, E.M, Ferrell, S.H, Tokars, V.L, Mondragon, A. | | 登録日 | 2022-05-09 | | 公開日 | 2022-07-06 | | 最終更新日 | 2022-08-17 | | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | | 主引用文献 | Structures of an active type III-A CRISPR effector complex.
Structure, 30, 2022
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4ZTH
 | | Structure of human p38aMAPK-arylpyridazinylpyridine fragment complex used in inhibitor discovery | | 分子名称: | 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE, 6-chloro-3-phenyl-4-(pyridin-4-yl)pyridazine, BETA-MERCAPTOETHANOL, ... | | 著者 | Grum-Tokars, V.L, Roy, S.M, Watterson, D.M. | | 登録日 | 2015-05-14 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A Selective and Brain Penetrant p38 alpha MAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.
J.Med.Chem., 62, 2019
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