1IRM
 
 | | Crystal structure of apo heme oxygenase-1 | | 分子名称: | apo heme oxygenase-1 | | 著者 | Sugishima, M, Sakamoto, H, Kakuta, Y, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | | 登録日 | 2001-10-09 | | 公開日 | 2002-07-10 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Crystal structure of rat apo-heme oxygenase-1 (HO-1): mechanism of heme binding in HO-1 inferred from structural comparison of the apo and heme complex forms
Biochemistry, 41, 2002
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1DVE
 | | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME | | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2000-01-20 | | 公開日 | 2000-04-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
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1IX4
 | | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Carbon Monoxide | | 分子名称: | CARBON MONOXIDE, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | | 登録日 | 2002-06-10 | | 公開日 | 2003-09-02 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
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1IX3
 | | Crystal Structure of Rat Heme Oxygenase-1 in complex with Heme bound to Cyanide | | 分子名称: | CYANIDE ION, HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | | 登録日 | 2002-06-10 | | 公開日 | 2003-09-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
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2SXL
 | | SEX-LETHAL RBD1, NMR, MINIMIZED AVERAGE STRUCTURE | | 分子名称: | SEX-LETHAL PROTEIN | | 著者 | Inoue, M, Muto, Y, Sakamoto, H, Kigawa, T, Takio, K, Shimura, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1997-07-16 | | 公開日 | 1998-07-22 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | A characteristic arrangement of aromatic amino acid residues in the solution structure of the amino-terminal RNA-binding domain of Drosophila sex-lethal.
J.Mol.Biol., 272, 1997
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6LUD
 | | Crystal Structure of EGFR(L858R/T790M/C797S) in complex with Osimertinib | | 分子名称: | Epidermal growth factor receptor, N-(2-{[2-(dimethylamino)ethyl](methyl)amino}-4-methoxy-5-{[4-(1-methyl-1H-indol-3-yl)pyrimidin-2-yl]amino}phenyl)prop-2-enamide | | 著者 | Kawauchi, H, Fukami, T.A, Sato, S, Endo, M, Torizawa, T, Kashima, K, Chiba, T, Sakamoto, H. | | 登録日 | 2020-01-27 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation.
Mol.Cancer Ther., 19, 2020
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6LUB
 | | Crystal Structure of EGFR(L858R/T790M/C797S) in complex with CH7233163 | | 分子名称: | Epidermal growth factor receptor, N-[2-(1-cyclopropylsulfonylpyrazol-4-yl)pyrimidin-4-yl]-7-(4-methylpiperazin-1-yl)-5-propan-2-yl-9-[2,2,2-tris(fluoranyl)ethoxy]pyrido[4,3-b]indol-3-amine | | 著者 | Kawauchi, H, Fukami, T.A, Sato, S, Endo, M, Torizawa, T, Kashima, K, Chiba, T, Sakamoto, H. | | 登録日 | 2020-01-27 | | 公開日 | 2020-10-07 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.315 Å) | | 主引用文献 | CH7233163 Overcomes Osimertinib-Resistant EGFR-Del19/T790M/C797S Mutation.
Mol.Cancer Ther., 19, 2020
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1B7F
 | | SXL-LETHAL PROTEIN/RNA COMPLEX | | 分子名称: | PROTEIN (SXL-LETHAL PROTEIN), RNA (5'-R(P*GP*UP*UP*GP*UP*UP*UP*UP*UP*UP*UP*U)-3') | | 著者 | Handa, N, Nureki, O, Kurimoto, K, Kim, I, Sakamoto, H, Shimura, Y, Muto, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1999-01-23 | | 公開日 | 1999-05-03 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein.
Nature, 398, 1999
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1C7W
 | | NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS | | 分子名称: | CALCIUM VECTOR PROTEIN | | 著者 | Theret, I, Baladi, S, Cox, J.A, Sakamoto, H, Craescu, C.T. | | 登録日 | 2000-03-27 | | 公開日 | 2000-04-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement.
Biochemistry, 39, 2000
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1C7V
 | | NMR SOLUTION STRUCTURE OF THE CALCIUM-BOUND C-TERMINAL DOMAIN (W81-S161) OF CALCIUM VECTOR PROTEIN FROM AMPHIOXUS | | 分子名称: | CALCIUM VECTOR PROTEIN | | 著者 | Theret, I, Baladi, S, Cox, J.A, Sakamoto, H, Craescu, C.T. | | 登録日 | 2000-03-27 | | 公開日 | 2000-04-12 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Sequential calcium binding to the regulatory domain of calcium vector protein reveals functional asymmetry and a novel mode of structural rearrangement.
Biochemistry, 39, 2000
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1D8Z
 | | SOLUTION STRUCTURE OF THE FIRST RNA-BINDING DOMAIN (RBD1) OF HU ANTIGEN C (HUC) | | 分子名称: | HU ANTIGEN C | | 著者 | Inoue, M, Muto, Y, Sakamoto, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1999-10-26 | | 公開日 | 2000-04-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C.
Nucleic Acids Res., 28, 2000
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1D9A
 | | SOLUTION STRUCTURE OF THE SECOND RNA-BINDING DOMAIN (RBD2) OF HU ANTIGEN C (HUC) | | 分子名称: | HU ANTIGEN C | | 著者 | Inoue, M, Muto, Y, Sakamoto, H, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1999-10-26 | | 公開日 | 2000-04-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR studies on functional structures of the AU-rich element-binding domains of Hu antigen C.
Nucleic Acids Res., 28, 2000
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1DVG
 | | CRYSTAL STRUCTURE OF RAT HEME OXYGENASE-1 IN COMPLEX WITH HEME; SELELENO-METHIONINE DERIVATIVE, MUTATED AT M51T,M93L,M155L,M191L. | | 分子名称: | HEME OXYGENASE-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Omata, Y, Kakuta, Y, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2000-01-20 | | 公開日 | 2000-04-12 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of rat heme oxygenase-1 in complex with heme.
FEBS Lett., 471, 2000
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1FNX
 | | SOLUTION STRUCTURE OF THE HUC RBD1-RBD2 COMPLEXED WITH THE AU-RICH ELEMENT | | 分子名称: | AU-RICH RNA ELEMENT, HU ANTIGEN C | | 著者 | Inoue, M, Hirao, M, Kasashima, K, Kim, I.-S, Kawai, G, Kigawa, T, Sakamoto, H, Muto, Y, Yokoyama, S. | | 登録日 | 2000-08-24 | | 公開日 | 2003-06-24 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of mouse HuC RNA-binding domains complexed with an AU-Rich element reveals determinants of neuronal differentiation
To be Published, 2000
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1J2C
 | | Crystal structure of rat heme oxygenase-1 in complex with biliverdin IXalpha-iron cluster | | 分子名称: | BILIVERDINE IX ALPHA, FE (III) ION, Heme Oxygenase-1 | | 著者 | Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2002-12-29 | | 公開日 | 2003-09-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of Rat Heme Oxygenase-1 in Complex with Biliverdin-Iron Chelate: CONFORMATIONAL CHANGE OF THE DISTAL HELIX DURING THE HEME CLEAVAGE REACTION.
J.Biol.Chem., 278, 2003
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1J7R
 | | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | | 分子名称: | Calcium Vector Protein | | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | | 登録日 | 2001-05-18 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein.
Biochemistry, 40, 2001
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1IVJ
 | | Crystal Structure of Rat Hemeoxygenase-1 in Complex with Heme and Azide. | | 分子名称: | AZIDE ION, Hemeoxygenase-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Sakamoto, H, Omata, Y, Hayashi, S, Noguchi, M, Fukuyama, K. | | 登録日 | 2002-03-18 | | 公開日 | 2002-12-11 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal Structure of Rat Heme Oxygenase-1 in Complex with Heme Bound to Azide. IMPLICATION FOR REGIOSPECIFIC HYDROXYLATION OF HEME AT THE alpha -MESO CARBON
J.Biol.Chem., 277, 2002
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1J7Q
 | | Solution structure and backbone dynamics of the defunct EF-hand domain of Calcium Vector Protein | | 分子名称: | Calcium Vector Protein | | 著者 | Theret, I, Baladi, S, Cox, J.A, Gallay, J, Sakamoto, H, Craescu, C.T. | | 登録日 | 2001-05-18 | | 公開日 | 2001-06-06 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure and backbone dynamics of the defunct domain of calcium vector protein.
Biochemistry, 40, 2001
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1UBB
 | | Crystal structure of rat HO-1 in complex with ferrous heme | | 分子名称: | Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Sakamoto, H, Higashimoto, Y, Noguchi, M, Fukuyama, K. | | 登録日 | 2003-04-03 | | 公開日 | 2003-09-02 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structures of Ferrous and CO-, CN(-)-, and NO-Bound Forms of Rat Heme Oxygenase-1 (HO-1) in Complex with Heme: Structural Implications for Discrimination between CO and O(2) in HO-1.
Biochemistry, 42, 2003
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1ULX
 | | Partially photolyzed structure of CO-bound heme-heme oxygenase complex | | 分子名称: | CARBON MONOXIDE, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2003-09-16 | | 公開日 | 2004-08-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
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1VGI
 | | Crystal structure of xenon bound rat heme-heme oxygenase-1 complex | | 分子名称: | FORMIC ACID, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE, ... | | 著者 | Sugishima, M, Sakamoto, H, Noguchi, M, Fukuyama, K. | | 登録日 | 2004-04-26 | | 公開日 | 2004-08-31 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | CO-trapping site in heme oxygenase revealed by photolysis of its co-bound heme complex: mechanism of escaping from product inhibition
J.Mol.Biol., 341, 2004
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3AOX
 | | X-ray crystal structure of human anaplastic lymphoma kinase in complex with CH5424802 | | 分子名称: | 1,2-ETHANEDIOL, 9-ethyl-6,6-dimethyl-8-[4-(morpholin-4-yl)piperidin-1-yl]-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile, ALK tyrosine kinase receptor | | 著者 | Nagel, S, Moertl, M, Jestel, A, Fukami, T.A. | | 登録日 | 2010-10-08 | | 公開日 | 2011-05-25 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant
Cancer Cell, 19, 2011
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2CMK
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1CKE
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1SAL
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