5FXR
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![BU of 5fxr by Molmil](/molmil-images/mine/5fxr) | IGFR-1R complex with a pyrimidine inhibitor. | 分子名称: | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(3-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | 著者 | Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C. | 登録日 | 2016-03-02 | 公開日 | 2016-10-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R). J. Med. Chem., 59, 2016
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5FXQ
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![BU of 5fxq by Molmil](/molmil-images/mine/5fxq) | IGFR-1R complex with a pyrimidine inhibitor. | 分子名称: | 5-chloranyl-4-imidazo[1,2-a]pyridin-3-yl-N-(5-methyl-1-piperidin-4-yl-pyrazol-4-yl)pyrimidin-2-amine, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | 著者 | Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C. | 登録日 | 2016-03-02 | 公開日 | 2016-10-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R). J. Med. Chem., 59, 2016
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5FXS
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![BU of 5fxs by Molmil](/molmil-images/mine/5fxs) | IGFR-1R complex with a pyrimidine inhibitor. | 分子名称: | 2-[4-[4-[[(6Z)-5-chloranyl-6-pyrazolo[1,5-a]pyridin-3-ylidene-1H-pyrimidin-2-yl]amino]-3,5-dimethyl-pyrazol-1-yl]piperidin-1-yl]-N,N-dimethyl-ethanamide, ACETATE ION, INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR | 著者 | Degorce, S, Boyd, S, Curwen, J, Ducray, R, Halsall, C, Jones, C, Lach, F, Lenz, E, Pass, M, Pass, S, Trigwell, C, Norman, R, Phillips, C. | 登録日 | 2016-03-02 | 公開日 | 2016-10-19 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a Potent, Selective, Orally Bioavailable, and Efficacious Novel 2-(Pyrazol-4-ylamino)-pyrimidine Inhibitor of the Insulin-like Growth Factor-1 Receptor (IGF-1R). J. Med. Chem., 59, 2016
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1LSQ
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![BU of 1lsq by Molmil](/molmil-images/mine/1lsq) | RIBONUCLEASE A WITH ASN 67 REPLACED BY A BETA-ASPARTYL RESIDUE | 分子名称: | RIBONUCLEASE A, SULFATE ION | 著者 | Esposito, L, Sica, F, Vitagliano, L, Zagari, A, Mazzarella, L. | 登録日 | 1996-06-25 | 公開日 | 1997-01-11 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Deamidation in proteins: the crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67. J.Mol.Biol., 257, 1996
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1R5D
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![BU of 1r5d by Molmil](/molmil-images/mine/1r5d) | X-ray structure of bovine seminal ribonuclease swapping dimer from a new crystal form | 分子名称: | Ribonuclease, seminal | 著者 | Merlino, A, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | 登録日 | 2003-10-10 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer Biopolymers, 73, 2004
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1BSR
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![BU of 1bsr by Molmil](/molmil-images/mine/1bsr) | |
11BG
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![BU of 11bg by Molmil](/molmil-images/mine/11bg) | A POTENTIAL ALLOSTERIC SUBSITE GENERATED BY DOMAIN SWAPPING IN BOVINE SEMINAL RIBONUCLEASE | 分子名称: | PROTEIN (BOVINE SEMINAL RIBONUCLEASE), SULFATE ION, URIDYLYL-2'-5'-PHOSPHO-GUANOSINE | 著者 | Vitagliano, L, Adinolfi, S, Sica, F, Merlino, A, Zagari, A, Mazzarella, L. | 登録日 | 1999-03-11 | 公開日 | 1999-11-05 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | A potential allosteric subsite generated by domain swapping in bovine seminal ribonuclease. J.Mol.Biol., 293, 1999
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11BA
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![BU of 11ba by Molmil](/molmil-images/mine/11ba) | BINDING OF A SUBSTRATE ANALOGUE TO A DOMAIN SWAPPING PROTEIN IN THE COMPLEX OF BOVINE SEMINAL RIBONUCLEASE WITH URIDYLYL-2',5'-ADENOSINE | 分子名称: | PROTEIN (RIBONUCLEASE, SEMINAL), SULFATE ION, ... | 著者 | Vitagliano, L, Adinolfi, S, Riccio, A, Sica, F, Zagari, A, Mazzarella, L. | 登録日 | 1999-03-17 | 公開日 | 1999-03-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | 主引用文献 | Binding of a substrate analog to a domain swapping protein: X-ray structure of the complex of bovine seminal ribonuclease with uridylyl(2',5')adenosine. Protein Sci., 7, 1998
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1R5C
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![BU of 1r5c by Molmil](/molmil-images/mine/1r5c) | X-ray structure of the complex of Bovine seminal ribonuclease swapping dimer with d(CpA) | 分子名称: | 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal | 著者 | Merlino, A, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | 登録日 | 2003-10-10 | 公開日 | 2004-04-13 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Population shift vs induced fit: The case of bovine seminal ribonuclease swapping dimer Biopolymers, 73, 2004
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1N3Z
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![BU of 1n3z by Molmil](/molmil-images/mine/1n3z) | Crystal structure of the [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] monomeric derivative of the bovine seminal ribonuclease in the liganded state | 分子名称: | 3'-URIDINEMONOPHOSPHATE, ADENOSINE, Ribonuclease, ... | 著者 | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | 登録日 | 2002-10-30 | 公開日 | 2003-08-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
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1N1X
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![BU of 1n1x by Molmil](/molmil-images/mine/1n1x) | Crystal Structure Analysis of the monomeric [S-carboxyamidomethyl-Cys31, S-carboxyamidomethyl-Cys32] Bovine seminal ribonuclease | 分子名称: | Ribonuclease, seminal | 著者 | Sica, F, Di Fiore, A, Zagari, A, Mazzarella, L. | 登録日 | 2002-10-21 | 公開日 | 2003-08-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative Proteins, 52, 2003
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4C0T
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1TQ9
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![BU of 1tq9 by Molmil](/molmil-images/mine/1tq9) | Non-covalent swapped dimer of Bovine Seminal Ribonuclease in complex with 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE | 分子名称: | 2'-DEOXYCYTIDINE-2'-DEOXYADENOSINE-3',5'-MONOPHOSPHATE, Ribonuclease, seminal | 著者 | Sica, F, Di Fiore, A, Merlino, A, Mazzarella, L. | 登録日 | 2004-06-17 | 公開日 | 2004-09-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure and Stability of the Non-covalent Swapped Dimer of Bovine Seminal Ribonuclease: AN ENZYME TAILORED TO EVADE RIBONUCLEASE PROTEIN INHIBITOR J.Biol.Chem., 279, 2004
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1DY5
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![BU of 1dy5 by Molmil](/molmil-images/mine/1dy5) | Deamidated derivative of bovine pancreatic ribonuclease | 分子名称: | ACETATE ION, ISOPROPYL ALCOHOL, RIBONUCLEASE A, ... | 著者 | Esposito, L, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | 登録日 | 2000-01-27 | 公開日 | 2000-03-28 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (0.87 Å) | 主引用文献 | The Ultrahigh Resolution Crystal Structure of Ribonuclease A Containing an Isoaspartyl Residue: Hydration and Sterochemical Analysis. J.Mol.Biol., 297, 2000
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1Y92
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![BU of 1y92 by Molmil](/molmil-images/mine/1y92) | Crystal structure of the P19A/N67D Variant Of Bovine seminal Ribonuclease | 分子名称: | Seminal ribonuclease | 著者 | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | 登録日 | 2004-12-14 | 公開日 | 2004-12-28 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
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1Y94
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![BU of 1y94 by Molmil](/molmil-images/mine/1y94) | Crystal structure of the G16S/N17T/P19A/S20A/N67D Variant Of Bovine seminal Ribonuclease | 分子名称: | Seminal ribonuclease | 著者 | Picone, D, Di Fiore, A, Ercole, C, Franzese, M, Sica, F, Tomaselli, S, Mazzarella, L. | 登録日 | 2004-12-14 | 公開日 | 2004-12-28 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Role of the Hinge Loop in Domain Swapping: THE SPECIAL CASE OF BOVINE SEMINAL RIBONUCLEASE. J.Biol.Chem., 280, 2005
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2NOJ
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1A2W
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![BU of 1a2w by Molmil](/molmil-images/mine/1a2w) | CRYSTAL STRUCTURE OF A 3D DOMAIN-SWAPPED DIMER OF BOVINE PANCREATIC RIBONUCLEASE A | 分子名称: | CHLORIDE ION, RIBONUCLEASE A, SULFATE ION | 著者 | Liu, Y, Hart, P.J, Schlunegger, M.P, Eisenberg, D.S. | 登録日 | 1998-01-12 | 公開日 | 1998-04-29 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The crystal structure of a 3D domain-swapped dimer of RNase A at a 2.1-A resolution. Proc.Natl.Acad.Sci.USA, 95, 1998
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1R3M
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![BU of 1r3m by Molmil](/molmil-images/mine/1r3m) | Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease | 分子名称: | PHOSPHATE ION, Ribonuclease, seminal | 著者 | Berisio, R, Sica, F, De Lorenzo, C, Di Fiore, A, Piccoli, R, Zagari, A, Mazzarella, L. | 登録日 | 2003-10-02 | 公開日 | 2003-11-18 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease Febs Lett., 554, 2003
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3BCP
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![BU of 3bcp by Molmil](/molmil-images/mine/3bcp) | Crystal Structure of The Swapped non covalent form of P19A/L28Q/N67D BS-RNase | 分子名称: | Seminal ribonuclease | 著者 | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | 登録日 | 2007-11-13 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.57 Å) | 主引用文献 | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3BCO
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![BU of 3bco by Molmil](/molmil-images/mine/3bco) | Crystal Structure of The Swapped FOrm of P19A/L28Q/N67D BS-RNase | 分子名称: | Seminal ribonuclease | 著者 | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | 登録日 | 2007-11-13 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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3BCM
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![BU of 3bcm by Molmil](/molmil-images/mine/3bcm) | Crystal Structure of The Unswapped Form of P19A/L28Q/N67D BS-RNase | 分子名称: | PHOSPHATE ION, Seminal ribonuclease | 著者 | Merlino, A, Ercole, C, Picone, D, Pizzo, E, Mazzarella, L, Sica, F. | 登録日 | 2007-11-13 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | The buried diversity of bovine seminal ribonuclease: shape and cytotoxicity of the swapped non-covalent form of the enzyme J.Mol.Biol., 376, 2008
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