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4TQC
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BU of 4tqc by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
分子名称: (2S)-3-(4-amino-3-nitrophenyl)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinyl}propanoic acid, 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Eukaryotic translation initiation factor 4E
著者Papadopoulos, E, Jenni, S, Wagner, G.
登録日2014-06-10
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TPW
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BU of 4tpw by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
分子名称: (2E)-2-{2-[4-(3,4-dichlorophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, ...
著者Papadopoulos, E, Jenni, S, Wagner, G.
登録日2014-06-09
公開日2014-08-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TQB
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BU of 4tqb by Molmil
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
分子名称: (2E)-2-{2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, ...
著者Papadopoulos, E, Jenni, S, Wagner, G.
登録日2014-06-10
公開日2014-08-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.
Proc.Natl.Acad.Sci.USA, 111, 2014
2KZ8
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BU of 2kz8 by Molmil
Solution NMR structure of MqsA, a protein from E. coli, containing a Zinc finger, N-terminal and a Helix Turn-Helix C-terminal domain
分子名称: Uncharacterized HTH-type transcriptional regulator ygiT
著者Papadopoulos, E, Vlamis-Gardikas, A, Graslund, A, Billeter, M, Holmgren, A, Collet, J.
登録日2010-06-14
公開日2011-06-29
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure and biophysical properties of MqsA, a Zn-containing antitoxin from Escherichia coli
Biochim.Biophys.Acta, 2012
1Z65
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BU of 1z65 by Molmil
Mouse Doppel 1-30 peptide
分子名称: Prion-like protein doppel
著者Papadopoulos, E.
登録日2005-03-21
公開日2006-02-07
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of the Peptide Fragment 1-30, Derived from Unprocessed Mouse Doppel Protein, in DHPC Micelles
Biochemistry, 45, 2006
7MEU
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BU of 7meu by Molmil
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders
分子名称: (2E)-2-{2-[4-([1,1'-biphenyl]-4-yl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E
著者Papadopoulos, E.
登録日2021-04-07
公開日2021-04-28
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
Eur.J.Med.Chem., 219, 2021
2K44
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BU of 2k44 by Molmil
Solution structure of a K+-channel voltage-sensor paddle domain
分子名称: K+-channel voltage-sensor paddle domain of Calcium-activated potassium channel subunit alpha-1
著者Unnerstale, S, Lind, J, Papadopoulos, E, Maler, L.
登録日2008-05-28
公開日2009-06-02
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the HsapBK K+-channel voltage-sensor paddle sequence
Biochemistry, 2009
5H7U
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NMR structure of eIF3 36-163
分子名称: Eukaryotic translation initiation factor 3 subunit C
著者Nagata, T, Obayashi, E.
登録日2016-11-21
公開日2017-05-31
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5.
Cell Rep, 18, 2017
2RVH
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BU of 2rvh by Molmil
NMR structure of eIF1
分子名称: Eukaryotic translation initiation factor eIF-1
著者Nagata, T, Obayashi, E, Asano, K.
登録日2015-10-16
公開日2016-10-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5
Cell Rep, 18, 2017
5BXV
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eIF4E complex
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4E, Eukaryotic translation initiation factor 4E-binding protein 1
著者Sekiyama, N, Arthanari, H, Papdopoulos, E, Rodriguez-Mias, R.A, Wagner, G, Leger-Abraham, M.
登録日2015-06-09
公開日2015-07-15
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1.
Proc.Natl.Acad.Sci.USA, 112, 2015

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