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1TYK
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SOLUTION STRUCTURE OF A TOXIN FROM THE TARANTULA, GRAMMOSTOLA SPATULATA, WHICH INHIBITS MECHANOSENSITIVE ION CHANNELS
分子名称: Toxin GsMTx-4
著者Oswald, R.E, Suchyna, T.M, Mcfeeters, R, Gottlieb, P, Sachs, F.
登録日2004-07-08
公開日2004-07-13
最終更新日2022-03-02
実験手法SOLUTION NMR
主引用文献Solution Structure of Peptide Toxins that Block Mechanosensitive Ion Channels
J.Biol.Chem., 277, 2002
1LUP
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BU of 1lup by Molmil
Solution structure of a toxin (GsMTx2) from the tarantula, Grammostola spatulata, which inhibits mechanosensitive ion channels
分子名称: GsMTx2
著者Oswald, R.E, Suchyna, T.M, McFeeters, R, Gottlieb, P, Sachs, F.
登録日2002-05-23
公開日2002-08-07
最終更新日2022-02-23
実験手法SOLUTION NMR
主引用文献Solution structure of peptide toxins that block mechanosensitive ion channels
J.Biol.Chem., 277, 2002
2NBT
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NEURONAL BUNGAROTOXIN, NMR, 10 STRUCTURES
分子名称: NEURONAL BUNGAROTOXIN
著者Oswald, R.E, Sutcliffe, M.J, Bamberger, M, Loring, R.H, Braswell, E, Dobson, C.M.
登録日1997-10-29
公開日1998-03-11
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Solution structure of neuronal bungarotoxin determined by two-dimensional NMR spectroscopy: calculation of tertiary structure using systematic homologous model building, dynamical simulated annealing, and restrained molecular dynamics.
Biochemistry, 31, 1992
3T9V
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BU of 3t9v by Molmil
CNQX bound to a reduced double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2
分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-08-03
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.975 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
3T9X
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Glutamate bound to a double cysteine mutant (V484C/E657C) of the ligand binding domain of GluA2
分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-08-03
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.823 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
3T96
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Iodowillardiine bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2
分子名称: 2-AMINO-3-(5-IODO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E.
登録日2011-08-02
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.872 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
4Q30
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Nitrowillardiine bound to the ligand binding domain of GluA2 at pH 3.5
分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2 CHIMERIC PROTEIN, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2014-04-10
公開日2014-06-04
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Thermodynamics and mechanism of the interaction of willardiine partial agonists with a glutamate receptor: implications for drug development.
Biochemistry, 53, 2014
1EES
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BU of 1ees by Molmil
SOLUTION STRUCTURE OF CDC42HS COMPLEXED WITH A PEPTIDE DERIVED FROM P-21 ACTIVATED KINASE, NMR, 20 STRUCTURES
分子名称: GTP-BINDING PROTEIN, P21-ACTIVATED KINASE
著者Gizachew, D, Guo, W, Chohan, K.C, Sutcliffe, M.J, Oswald, R.E.
登録日2000-02-02
公開日2000-03-29
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Structure of the complex of Cdc42Hs with a peptide derived from P-21 activated kinase.
Biochemistry, 39, 2000
3T93
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Glutamate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2
分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-08-02
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.907 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
3T9U
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CNQX bound to an oxidized double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2
分子名称: 7-nitro-2,3-dioxo-2,3-dihydroquinoxaline-6-carbonitrile, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-08-03
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
3T9H
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Kainate bound to a double cysteine mutant (A452C/S652C) of the ligand binding domain of GluA2
分子名称: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Wang, S, Chuang, H.H, Oswald, R.E.
登録日2011-08-02
公開日2011-08-17
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.015 Å)
主引用文献Mechanism of AMPA Receptor Activation by Partial Agonists: DISULFIDE TRAPPING OF CLOSED LOBE CONFORMATIONS.
J.Biol.Chem., 286, 2011
2MOG
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BU of 2mog by Molmil
Solution structure of the terminal Ig-like domain from Leptospira interrogans LigB
分子名称: Bacterial Ig-like domain, group 2
著者Ptak, C.P, Hsieh, C, Lin, Y, Maltsev, A.S, Raman, R, Sharma, Y, Oswald, R.E, Chang, Y.
登録日2014-04-25
公開日2014-08-13
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of the Terminal Immunoglobulin-like Domain from the Leptospira Host-Interacting Outer Membrane Protein, LigB.
Biochemistry, 53, 2014
3RTF
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Chlorowillardiine bound to the ligand binding domain of GluA2
分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-05-03
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
3RT6
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Fluorowillardiine bound to the ligand binding domain of GluA3
分子名称: 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-05-03
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.836 Å)
主引用文献Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
3RT8
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Chlorowillardiine bound to the ligand binding domain of GluA3
分子名称: 3-(5-chloro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-05-03
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.426 Å)
主引用文献Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
3RTW
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Nitrowillardiine bound to the ligand binding domain of GluA2
分子名称: 3-(5-nitro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Oswald, R.E.
登録日2011-05-04
公開日2011-05-18
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.095 Å)
主引用文献Mechanisms of Modal Activation of GluA3 Receptors.
Mol.Pharmacol., 80, 2011
3DP6
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Crystal structure of the binding domain of the AMPA subunit GluR2 bound to glutamate
分子名称: GLUTAMIC ACID, Glutamate receptor 2, ZINC ION
著者Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E.
登録日2008-07-07
公開日2008-11-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
3DLN
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BU of 3dln by Molmil
Crystal structure of the binding domain of the AMPA subunit GluR3 bound to glutamate
分子名称: GLUTAMIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E.
登録日2008-06-27
公開日2008-11-25
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
3DP4
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Crystal structure of the binding domain of the AMPA subunit GluR3 bound to AMPA
分子名称: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, Glutamate receptor 3, ZINC ION
著者Ahmed, A.H, Wang, Q, Sondermann, H, Oswald, R.E.
登録日2008-07-07
公開日2008-11-25
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structure of the S1S2 glutamate binding domain of GLuR3.
Proteins, 75, 2008
2ASE
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BU of 2ase by Molmil
NMR structure of the F28L mutant of Cdc42Hs
分子名称: Cell division control protein 42 homolog
著者Adams, P.D, Oswald, R.E.
登録日2005-08-23
公開日2006-02-21
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution Structure of an Oncogenic Mutant of Cdc42Hs
Biochemistry, 45, 2006
3LSW
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BU of 3lsw by Molmil
Aniracetam bound to the ligand binding domain of GluA3
分子名称: 1-(4-METHOXYBENZOYL)-2-PYRROLIDINONE, GLUTAMIC ACID, GluA2 S1S2 domain, ...
著者Ahmed, A.H, Oswald, R.E.
登録日2010-02-13
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.752 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSX
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Piracetam bound to the ligand binding domain of GluA3
分子名称: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, GluA3 S1S2 domain, ...
著者Ahmed, A.H, Oswald, R.E.
登録日2010-02-13
公開日2011-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSF
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Piracetam bound to the ligand binding domain of GluA2
分子名称: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ...
著者Ahmed, A.H, Ptak, C.P, Oswald, R.E.
登録日2010-02-12
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3LSL
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Piracetam bound to the ligand binding domain of GluA2 (flop form)
分子名称: 2-(2-oxopyrrolidin-1-yl)acetamide, GLUTAMIC ACID, Glutamate receptor 2, ...
著者Ahmed, A.H, Oswald, R.E.
登録日2010-02-12
公開日2010-03-16
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.122 Å)
主引用文献Piracetam Defines a New Binding Site for Allosteric Modulators of alpha-Amino-3-hydroxy-5-methyl-4-isoxazole-propionic Acid (AMPA) Receptors.
J.Med.Chem., 53, 2010
3M3F
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PEPA bound to the ligand binding domain of GluA3 (flop form)
分子名称: 2-[2,6-difluoro-4-({2-[(phenylsulfonyl)amino]ethyl}sulfanyl)phenoxy]acetamide, GLUTAMIC ACID, Glutamate receptor 3, ...
著者Ahmed, A.H, Ptak, C.P, Oswald, R.E.
登録日2010-03-09
公開日2010-03-23
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Biochemistry, 49, 2010

 

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