2ZTM
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![BU of 2ztm by Molmil](/molmil-images/mine/2ztm) | T190S mutant of D-3-hydroxybutyrate dehydrogenase | 分子名称: | (3S)-3-HYDROXYBUTANOIC ACID, D(-)-3-hydroxybutyrate dehydrogenase, MAGNESIUM ION, ... | 著者 | Nakashima, K, Nakajima, Y, Ito, K, Yoshimoto, T. | 登録日 | 2008-10-07 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem., 145, 2009
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2ZTL
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![BU of 2ztl by Molmil](/molmil-images/mine/2ztl) | Closed conformation of D-3-hydroxybutyrate dehydrogenase complexed with NAD+ and L-3-hydroxybutyrate | 分子名称: | (3S)-3-HYDROXYBUTANOIC ACID, D(-)-3-hydroxybutyrate dehydrogenase, GLYCEROL, ... | 著者 | Nakashima, K, Nakajima, Y, Ito, K, Yoshimoto, T. | 登録日 | 2008-10-07 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem., 145, 2009
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2ZTU
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![BU of 2ztu by Molmil](/molmil-images/mine/2ztu) | T190A mutant of D-3-hydroxybutyrate dehydrogenase complexed with NAD+ | 分子名称: | D(-)-3-hydroxybutyrate dehydrogenase, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Nakashima, K, Nakajima, Y, Ito, K, Yoshimoto, T. | 登録日 | 2008-10-09 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem., 145, 2009
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2ZTV
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![BU of 2ztv by Molmil](/molmil-images/mine/2ztv) | The binary complex of D-3-hydroxybutyrate dehydrogenase with NAD+ | 分子名称: | D(-)-3-hydroxybutyrate dehydrogenase, GLYCEROL, MAGNESIUM ION, ... | 著者 | Nakashima, K, Nakajima, Y, Ito, K, Yoshimoto, T. | 登録日 | 2008-10-09 | 公開日 | 2009-08-25 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Closed complex of the D-3-hydroxybutyrate dehydrogenase induced by an enantiomeric competitive inhibitor. J.Biochem., 145, 2009
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2RVP
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![BU of 2rvp by Molmil](/molmil-images/mine/2rvp) | Solution structure of DNA Containing Metallo-Base-Pair | 分子名称: | DNA (5'-D(*TP*AP*AP*TP*AP*TP*AP*CP*TP*TP*AP*AP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*TP*TP*AP*AP*CP*TP*AP*TP*AP*TP*TP*A)-3'), SILVER ION | 著者 | Dairaku, T, Furuita, K, Sato, H, Sebera, J, Nakashima, K, Kondo, J, Yamanaka, D, Kondo, Y, Okamoto, I, Ono, A, Sychrovsky, V, Kojima, C, Tanaka, Y. | 登録日 | 2016-03-22 | 公開日 | 2016-08-31 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure Determination of an Ag(I) -Mediated Cytosine-Cytosine Base Pair within DNA Duplex in Solution with (1) H/(15) N/(109) Ag NMR Spectroscopy. Chemistry, 22, 2016
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1F54
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![BU of 1f54 by Molmil](/molmil-images/mine/1f54) | SOLUTION STRUCTURE OF THE APO N-TERMINAL DOMAIN OF YEAST CALMODULIN | 分子名称: | CALMODULIN | 著者 | Ishida, H, Takahashi, K, Nakashima, K, Kumaki, Y, Nakata, M, Hikichi, K, Yazawa, M. | 登録日 | 2000-06-13 | 公開日 | 2003-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structures of the N-terminal Domain of Yeast Calmodulin:
Ca2+-Dependent Conformational Change and Its Functional Implication Biochemistry, 39, 2000
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1F55
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![BU of 1f55 by Molmil](/molmil-images/mine/1f55) | SOLUTION STRUCTURE OF THE CALCIUM BOUND N-TERMINAL DOMAIN OF YEAST CALMODULIN | 分子名称: | CALCIUM ION, CALMODULIN | 著者 | Ishida, H, Takahashi, K, Nakashima, K, Kumaki, Y, Nakata, M, Hikichi, K, Yazawa, M. | 登録日 | 2000-06-13 | 公開日 | 2003-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structures of the N-terminal Domain of Yeast Calmodulin:
Ca2+-Dependent Conformational Change and Its Functional Implication Biochemistry, 39, 2000
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1LKJ
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![BU of 1lkj by Molmil](/molmil-images/mine/1lkj) | NMR Structure of Apo Calmodulin from Yeast Saccharomyces cerevisiae | 分子名称: | Calmodulin | 著者 | Ishida, H, Nakashima, K, Kumaki, Y, Nakata, M, Hikichi, K, Yazawa, M. | 登録日 | 2002-04-25 | 公開日 | 2003-04-29 | 最終更新日 | 2024-05-29 | 実験手法 | SOLUTION NMR | 主引用文献 | The solution structure of apocalmodulin from Saccharomyces cerevisiae implies a mechanism for its unique Ca2+ binding property. Biochemistry, 41, 2002
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1WDA
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![BU of 1wda by Molmil](/molmil-images/mine/1wda) | Crystal structure of human peptidylarginine deiminase type4 (PAD4) in complex with benzoyl-L-arginine amide | 分子名称: | CALCIUM ION, N-[(E)-2-AMINO-1-(3-{[AMINO(IMINO)METHYL]AMINO}PROPYL)-2-HYDROXYVINYL]BENZAMIDE, Protein-arginine deiminase type IV, ... | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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1WD8
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![BU of 1wd8 by Molmil](/molmil-images/mine/1wd8) | Calcium free form of human peptidylarginine deiminase type4 (PAD4) | 分子名称: | Protein-arginine deiminase type IV | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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1WD9
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![BU of 1wd9 by Molmil](/molmil-images/mine/1wd9) | Calcium bound form of human peptidylarginine deiminase type4 (PAD4) | 分子名称: | CALCIUM ION, Protein-arginine deiminase type IV, SULFATE ION | 著者 | Arita, K, Hashimoto, H, Shimizu, T, Nakashima, K, Yamada, M, Sato, M. | 登録日 | 2004-05-12 | 公開日 | 2004-07-13 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structural basis for Ca(2+)-induced activation of human PAD4 Nat.Struct.Mol.Biol., 11, 2004
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5VP0
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![BU of 5vp0 by Molmil](/molmil-images/mine/5vp0) | Discovery of Clinical Candidate N-{(1S)-1-[3-Fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915), A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders | 分子名称: | MAGNESIUM ION, N-{(1S)-1-[3-fluoro-4-(trifluoromethoxy)phenyl]-2-methoxyethyl}-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide, ZINC ION, ... | 著者 | Hoffman, I.D. | 登録日 | 2017-05-03 | 公開日 | 2017-08-23 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders. J. Med. Chem., 60, 2017
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1WMB
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![BU of 1wmb by Molmil](/molmil-images/mine/1wmb) | Crystal structure of NAD dependent D-3-hydroxybutylate dehydrogenase | 分子名称: | CACODYLATE ION, D(-)-3-hydroxybutyrate dehydrogenase, MAGNESIUM ION | 著者 | Ito, K, Nakajima, Y, Ichihara, E, Ogawa, K, Yoshimoto, T. | 登録日 | 2004-07-06 | 公開日 | 2005-09-06 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | d-3-Hydroxybutyrate Dehydrogenase from Pseudomonas fragi: Molecular Cloning of the Enzyme Gene and Crystal Structure of the Enzyme J.Mol.Biol., 355, 2006
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1X1T
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![BU of 1x1t by Molmil](/molmil-images/mine/1x1t) | Crystal Structure of D-3-Hydroxybutyrate Dehydrogenase from Pseudomonas fragi Complexed with NAD+ | 分子名称: | CACODYLATE ION, D(-)-3-hydroxybutyrate dehydrogenase, MAGNESIUM ION, ... | 著者 | Ito, K, Nakajima, Y, Ichihara, E, Ogawa, K, Yoshimoto, T. | 登録日 | 2005-04-13 | 公開日 | 2006-01-10 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | d-3-Hydroxybutyrate Dehydrogenase from Pseudomonas fragi: Molecular Cloning of the Enzyme Gene and Crystal Structure of the Enzyme J.Mol.Biol., 355, 2006
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1X2E
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![BU of 1x2e by Molmil](/molmil-images/mine/1x2e) | The crystal structure of prolyl aminopeptidase complexed with Ala-TBODA | 分子名称: | (2S)-2-AMINO-1-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)PROPAN-1-ONE, Proline iminopeptidase | 著者 | Nakajima, Y, Ito, K, Sakata, M, Xu, Y, Matsubara, F, Hatakeyama, S, Yoshimoto, T. | 登録日 | 2005-04-22 | 公開日 | 2006-05-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens J.Bacteriol., 188, 2006
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1X2B
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![BU of 1x2b by Molmil](/molmil-images/mine/1x2b) | The crystal structure of prolyl aminopeptidase complexed with Sar-TBODA | 分子名称: | 1-(5-TERT-BUTYL-1,3,4-OXADIAZOL-2-YL)-2-(METHYLAMINO)ETHANONE, Proline iminopeptidase | 著者 | Nakajima, Y, Ito, K, Sakata, M, Xu, Y, Matsubara, F, Hatakeyama, S, Yoshimoto, T. | 登録日 | 2005-04-22 | 公開日 | 2006-05-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Unusual extra space at the active site and high activity for acetylated hydroxyproline of prolyl aminopeptidase from Serratia marcescens J.Bacteriol., 188, 2006
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2DQM
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![BU of 2dqm by Molmil](/molmil-images/mine/2dqm) | Crystal Structure of Aminopeptidase N complexed with bestatin | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, Aminopeptidase N, SULFATE ION, ... | 著者 | Onohara, Y, Nakajima, Y, Ito, K, Yoshimoto, T. | 登録日 | 2006-05-29 | 公開日 | 2006-08-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition J.Biol.Chem., 281, 2006
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2DQ6
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![BU of 2dq6 by Molmil](/molmil-images/mine/2dq6) | Crystal Structure of Aminopeptidase N from Escherichia coli | 分子名称: | Aminopeptidase N, SULFATE ION, ZINC ION | 著者 | Nakajima, Y, Onohara, Y, Ito, K, Yoshimoto, T. | 登録日 | 2006-05-22 | 公開日 | 2006-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Aminopeptidase N (proteobacteria alanyl aminopeptidase) from Escherichia coli: Crystal structure and conformational change of the methionine 260 residue involved in substrate recognition J.Biol.Chem., 281, 2006
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5AXQ
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![BU of 5axq by Molmil](/molmil-images/mine/5axq) | Crystal structure of the catalytic domain of PDE10A complexed with highly potent and brain-penetrant PDE10A Inhibitor with 2-oxindole scaffold | 分子名称: | 1-(cyclopropylmethyl)-4-fluoranyl-5-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]-3,3-dimethyl-indol-2-one, 3-[3-fluoranyl-4-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]phenyl]-1,3-oxazolidin-2-one, MAGNESIUM ION, ... | 著者 | Oki, H, Zama, Y. | 登録日 | 2015-07-31 | 公開日 | 2015-11-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor Bioorg.Med.Chem., 23, 2015
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5B4L
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![BU of 5b4l by Molmil](/molmil-images/mine/5b4l) | Crystal structure of the catalytic domain of human PDE10A complexed with 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one | 分子名称: | 1-(cyclopropylmethyl)-5-(2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Oki, H, Zama, Y. | 登録日 | 2016-04-05 | 公開日 | 2016-06-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket Bioorg.Med.Chem., 24, 2016
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5AXP
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![BU of 5axp by Molmil](/molmil-images/mine/5axp) | Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(2-oxo-1,3-oxazolidin-3-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one | 分子名称: | 3-[3-fluoranyl-4-[5-methoxy-4-oxidanylidene-3-(2-phenylpyrazol-3-yl)pyridazin-1-yl]phenyl]-1,3-oxazolidin-2-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Oki, H, Zama, Y. | 登録日 | 2015-07-31 | 公開日 | 2015-11-11 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor Bioorg.Med.Chem., 23, 2015
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5B4K
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![BU of 5b4k by Molmil](/molmil-images/mine/5b4k) | Crystal structure of the catalytic domain of human PDE10A complexed with N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine | 分子名称: | MAGNESIUM ION, N-(4-((5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy)phenyl)-1H-benzimidazol-2-amine, ZINC ION, ... | 著者 | Oki, H, Zama, Y. | 登録日 | 2016-04-05 | 公開日 | 2016-06-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket Bioorg.Med.Chem., 24, 2016
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3WYM
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![BU of 3wym by Molmil](/molmil-images/mine/3wym) | Crystal structure of the catalytic domain of PDE10A complexed with 1-(2-fluoro-4-(1H-pyrazol-1-yl)phenyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one | 分子名称: | 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Oki, H, Hayano, Y. | 登録日 | 2014-09-01 | 公開日 | 2014-11-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. J.Med.Chem., 57, 2014
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3WYK
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![BU of 3wyk by Molmil](/molmil-images/mine/3wyk) | Crystal structure of the catalytic domain of PDE10A complexed with 3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one | 分子名称: | 3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Oki, H, Hayano, Y. | 登録日 | 2014-09-01 | 公開日 | 2014-11-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. J.Med.Chem., 57, 2014
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3WYL
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![BU of 3wyl by Molmil](/molmil-images/mine/3wyl) | Crystal structure of the catalytic domain of PDE10A complexed with 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(3-(trifluoromethyl)phenyl)pyridazin-4(1H)-one | 分子名称: | 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one, MAGNESIUM ION, ZINC ION, ... | 著者 | Oki, H, Hayano, Y. | 登録日 | 2014-09-01 | 公開日 | 2014-11-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | 主引用文献 | Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. J.Med.Chem., 57, 2014
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